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GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins?

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endoCANNABINOIDS

Part of the book series: The Receptors ((REC,volume 24))

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Abstract

A review of what is presently known about the G protein-coupled receptor GPR18, which activated by the phytocannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) and N-arachidonoyl glycine (NAGly) by an oxygenated metabolite of the endogenous cannabinoid anandamide (AEA). The review will outline what is known about this receptor, the ligands that activate and block the receptor, and how these interactions fit within cannabinoid/endocannabinoid signaling.

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Authors and Affiliations

  1. Program in Neuroscience, Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA

    Douglas McHugh & Heather B. Bradshaw

Authors
  1. Douglas McHugh
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  2. Heather B. Bradshaw
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Corresponding author

Correspondence to Douglas McHugh .

Editor information

Editors and Affiliations

  1. , Anatomy and Cell Biology, Temple University School of Medicine, 3500 N. Broad Street, Philadelphia, 19140, Pennsylvania, USA

    Mary E. Abood

  2. National Institutes of Health, Division of Basic Neuroscience and Behav, National Institute on Drug Abuse, 6001 Executive Blvd, Bethesda, 20892, Maryland, USA

    Roger G Sorensen

  3. , Pharmacology and Psychiatry and Behavior, University of Washington, Box 357280, Seattle, 98195, Washington, USA

    Nephi Stella

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McHugh, D., Bradshaw, H.B. (2013). GPR18 and NAGly Signaling: New Members of the Endocannabinoid Family or Distant Cousins?. In: Abood, M., Sorensen, R., Stella, N. (eds) endoCANNABINOIDS. The Receptors, vol 24. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4669-9_6

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