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The Role of Notch Signaling in Multiple Myeloma

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Genetic and Molecular Epidemiology of Multiple Myeloma

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Abstract

The bone marrow (BM) microenvironment plays a critical role in the multiple myeloma (MM) cell growth and survival. As a highly conserved cell signaling system, the Notch pathway is considered to regulate cell-fate determination, stem cell self-renewal, proliferation, and apoptosis. Notch receptors and ligands are expressed both in MM cells and the BM microenvironment. In this review, we mainly discuss the canonical Notch signaling pathway including background and components of the signaling, its activation, the downstream targets, its regulation, and cross talk with other pathways. We further focus on the role of Notch signaling in multiple myeloma cell growth, angiogenesis, differentiation, drug resistance, bone disease, metastasis, and stem cell biology. A better understanding of Notch signaling in myeloma may provide new strategies to improve current treatment and overall survival.

Both authors contributed equally

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Authors and Affiliations

  1. Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090, Brussels, Belgium

    Dehui Xu, Jinsong Hu, Elke De Bruyne, Eline Menu, Karin Vanderkerken & Els Van Valckenborgh

  2. Department of Molecular Biology and Genetics, Medical School of Xi’an Jiaotong University, Xi’an, China

    Dehui Xu & Jinsong Hu

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  1. Dehui Xu
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  2. Jinsong Hu
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  3. Elke De Bruyne
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  4. Eline Menu
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  5. Karin Vanderkerken
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  6. Els Van Valckenborgh
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Correspondence to Els Van Valckenborgh .

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  1. College of Physicians and Surgeons, Multiple Myeloma and Amyloidosis Service, Columbia University, 161 Fort Washington Avenue, New York, 10032, New York, USA

    Suzanne Lentzsch

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Xu, D., Hu, J., De Bruyne, E., Menu, E., Vanderkerken, K., Van Valckenborgh, E. (2013). The Role of Notch Signaling in Multiple Myeloma. In: Lentzsch, S. (eds) Genetic and Molecular Epidemiology of Multiple Myeloma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4660-6_5

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