Abstract
This chapter provides a synopsis of the anatomy and physiology of the gastrointestinal tract of small animals, specifically cats and dogs. The stomach is both a grinding organ and a reservoir, metering foodstuffs into the small intestine for further processing and absorption. The small intestine is the primary site of absorption. On the one hand, the gastrointestinal tracts’ acidified stomach contents may result in the precipitation of pharmaceuticals. On the other hand, in response to food, the secretion of pancreatic fluid, bile salts and lecithin in the small intestine may result in a fine emulsion that facilitates the aqueous solubility and subsequent absorption of the pharmaceutical ingredient (API). The large intestine (cecum and colon) completes the processing and absorption of nutrients. Absorption of the API in this region is balanced by its solubility and residence time in this organ. This chapter shows that there appear to be many similarities in the anatomy and physiology of mammals.
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References
HumaneSociety (2011) Pets. http://www.humanesociety.org/animals/pets/
AKA (2011) Breeds. http://www.americankennelassociat.org/
Patronek GJ, Waters DJ, Glickman LT (1997) Comparative longevity of pet dogs and humans: implications for gerontology research. J Gerontol A Biol Sci Med Sci 52A:B171–B178
de Zwart I, de Roos A (2010) MRI for the evaluation of gastric physiology. Eur Radiol 20:2609–2616
Geigy (1981) Units of measurement, body fluids, composition of the body, nutrition. In: Lentnered C (ed) Geigy scientific tables. CIBA-GEIGY Ltd, Basel, Switzerland
Kararli T (1995) Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 16:351–380
Janssen P, Tack J, Sifrim D, Meulemans AL, Lefebvre RA (2004) Influence of 5-HT1 receptor agonists on feline stomach relaxation. Eur J Pharmacol 492:259–267
Beitz D, Bauer J, Behnke K, Dzanis D, Fahey G, Hill R, Kallfelz F, Kienzle E, Morris J, Rogers Q (2006) Nutrient requirements of dogs and cats. In: NRCotN Academies (ed) Animal nutrition series. The National Academies Press, Washington, DC
Schubert ML, Peura DA (2008) Control of gastric acid secretion in health and disease. Gastroenterology 134:1842–1860
Sutton SC, Smith PL (2011) Animal Model Systems Suitable for Controlled Release Modeling, in Controlled Release in Oral Drug Delivery, Wilson CG, Crowley PJ (eds) Springer: Glasgow. p. 71–90
Brosey BP, Hill RC, Scott KC (2000) Gastrointestinal volatile fatty acid concentrations and pH in cats. Am J Vet Res 61:359–361
Lui CY, Amidon GE, Berardi RR, Fleisher D, Youngberg CA, Dressman JB (1986) Comparison of gastrointestinal pH in dogs and humans: implications on the use of the beagle dog as a model for oral absorption in humans. J Pharm Sci 75:271–274
Polentarutti B, Albery T, Dressman J, Abrahamsson B (2010) Modification of gastric pH in the fasted dog. J Pharm Pharmacol 62:462–469
Sagawa K, Li F, Liese R, Sutton S (2009) Fed and fasted gastric pH and gastric residence time in conscious beagle dogs. J Pharm Sci 98:2494–2500
Sutton SC (2008) Companion animal physiology and dosage form performance. Adv Drug Del Rev 56:1383–1398
Hasler W (2008) The physiology of gastric motility and gastric emptying. In: Yamadaed T (ed) Textbook of gastroenterology. Blackwell, Oxford
Wyse CA, McLellan J, Dickie AM, Sutton DGM, Preston T, Yam PS (2003) A review of methods for assessment of the rate of gastric emptying in the dog and cat: 1898–2002. J Vet Intern Med 17:609–621
Martinez MN, Papich MG (2009) Factors influencing the gastric residence of dosage forms in dogs. J Pharm Sci 98:844–860
Dressman JB (1986) Comparison of canine and human gastrointestinal physiology. Pharm Res 3:123–131
Chandler M, Guilford G, Lawoko C (1997) Radiopaque markers to evaluate gastric emptying and small intestinal transit time in healthy cats. J Vet Int Med 11:361–364
Peachey SE, Dawson JM, Harper EJ (2000) Gastrointestinal transit times in young and old cats. Comp Biochem Physiol A Mol Integr Physiol 126:85–90
Chandler ML, Guilford G, Lawoko CRO (1997) Radiopaque markers to evaluate gastric emptying and small intestinal transit time in healthy cats. J Vet Intern Med 11:361–364
Allan FJ, Guilford WG, Robertson ID, Jones BR (1996) Gastric emptying of solid radiopaque markers in healthy dogs. Vet Radiol Ultrasound 37:336–344
Szurszewski J (1969) A migrating electric complex of canine small intestine. Am J Physiol 217:1757–1763
Fordtran JS, Dietschy J (1968) Water and electrolyte movement in the intestine. Gastroenterology 50:263–285
Kararli T (1989) Gastrointestinal absorption of drugs. Crit Rev Ther Drug Carrier Syst 6:39–86
Radberg G, Svanvik J (1986) Influence of pregnancy, oophorectomy and contraceptive steroids on gall bladder concentrating function and hepatic bile flow in the cat. Gut 27:10–14
Rabin B, Nicolosi R, Hayes K (1976) Dietary influence on bile acid conjugation in the cat. J Nutr 106:1241–1246
Johnston KL, Ballevre OP, Batt RM (2001) Use of an orally administered combined sugar solution to evaluate intestinal absorption and permeability in cats. Am J Vet Res 62:111–118
Chiou WL, Jeong H, Chung S, TC W (2000) Evaluation of using the dog as an animal model to study the fraction of oral dose absorbed of 43 drugs in humans. Pharm Res 17:135–140
Wienbeck M, Wallenfels M, Kortenhaus E (1987) Ricinoleic acid and loperamide have opposite motor effects in the small and large intestine of the cat. Z Gastroenterol 25:355–363
Chandler ML, Guilford WG, Lawoko CR, Whittem T (1999) Gastric emptying and intestinal transit times of radiopaque markers in cats fed a high-fiber diet with and without low-dose intravenous diazepam. Vet Radiol Ultrasound 40:3–8
Tanaka A, Inoue A, Takeguchi A, Washizu T, Bonkobara M, Arai T (2005) Comparison of expression of glucokinase gene and activities of enzymes related to glucose metabolism in livers between dog and cat. Vet Res Commun 29:477–485
Chauret N, Gauthier A, Martin J, Nicoll-Griffith DA (1997) In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse. Drug Metab Dispos 25:1130–1136
Mealey KL, Bentjen SA, Gay JM, Cantor GH (2001) Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11:727–733
Suchodolski J (2011) Microbes and gastrointestinal health of dogs and cats. J Anim Sci 89:1520–1530
Komura H, Iwaki M (2011) In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences. Drug Metab Rev 43:476–498
Sarna SK, Prasad KR, Lang IM (1988) Giant migrating contractions of the canine cecum. Am J Physiol Gastrointest Liver Physiol 254:G595–G601
Jeppesen PB, Mortensen PB (1998) The influence of a preserved colon on the absorption of medium chain fat in patients with small bowel resection. Gut 43:478–483
Shimoyama Y, Kirat D, Akihara Y, Kawasako K, Komine M, Hirayama K, Matsuda K, Okamoto M, Iwano H, Kato S, Taniyama H, Shimoyama Y, Kirat D, Akihara Y, Kawasako K, Komine M, Hirayama K, Matsuda K, Okamoto M, Iwano H, Kato S, Taniyama H (2007) Expression of monocarboxylate transporter 1 (MCT1) in the dog intestine. J Vet Med Sci 69:599–604
West DA, Fortner JH, Sutton SC, Sagawa K, Novak EN, Rogers KL, Volberg ML, Trombley J, Evans LAF, McCarthy JM (2005) Canine model for colonic drug absorption. in 56th AALAS National Meeting. St. Louis, MO
Maskell I, Johnson K (1993) Digestion and absorption. In: Burger I (ed) The Waltham book of companion animal nutrition. Pergamon Press, New York
HillsVet.com (2012) Atlas of veterinary clinical anatomy. http://www.hillsvet.com/practice-management/feline-colon-normal.html
Smith HW (1965) Observations on the flora of the alimentary tract of animals and factors affecting its composition. J Pathol Bacteriol 89:95–122
Sutton S (2009) Role of physiological intestinal water in oral absorption. AAPS J 11:277–285
Wienbeck M, Kortenhaus E, Wallenfels M, Karaus M (1988) Effect of sennosides on colon motility in cats. Pharmacology 36:31–39
McGirr MEA, McAllister SM, Peters EE, Vickers AW, Parr AF, Basit AW (2009) The use of the InteliSite® Companion device to deliver mucoadhesive polymers to the dog colon. Eur J Pharm Sci 36:386–391
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Sutton, S.C. (2013). Oral Anatomy and Physiology in the Companion Animal. In: Rathbone, M., McDowell, A. (eds) Long Acting Animal Health Drug Products. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4439-8_4
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DOI: https://doi.org/10.1007/978-1-4614-4439-8_4
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