Abstract
The technology of controlled release has always been attractive to veterinary vaccine developers as it has potential to bring a level of convenience, efficacy, and compliance to the use of vaccines. The ability to have in a single therapy or device all that it is required to sensitize and protect an animal may deliver access to new markets, provide differentiation to existing products, and solve hitherto unmet needs in veterinary immunology. However, few controlled release vaccine formulations are available at this time despite the sophistication of the materials and devices used for controlled release of medical and veterinary therapeutics. Recent advances in our understanding of how the immune system is sensitized is beginning to allow us to apply new and old technology of controlled release to vaccines across a number of livestock and companion animal species. The technology allows us to control how antigen and adjuvant are presented to the host with increasing fidelity resulting in appropriate levels and duration of immunity. The discovery that many adjuvants work by stimulating the innate immune system has led to the development of molecular adjuvants, which are well suited to devices and controlled release formulations. As controlled release vaccine formulations near late development there are regulatory concerns that need to be addressed as familiar and unfamiliar vaccine components are presented to regulators in a persistent form.
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Elhay, M.J. (2013). Veterinary Vaccines. In: Rathbone, M., McDowell, A. (eds) Long Acting Animal Health Drug Products. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4439-8_14
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DOI: https://doi.org/10.1007/978-1-4614-4439-8_14
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