Abstract
Cells from different tumour cell lines can be grown in vitro to form spheroidal masses, called multicellular tumour spheroids, currently considered valuable experimental models of avascular tumours [35, 37, 50, 51, 58]. Multicellular tumour spheroids have been extensively investigated in that they provide a useful model to assess the effects of oxygenation and nutrition on growth, as well as the effects of treatments with drugs and radiation.
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Acknowledgements
The present work was partially supported by the PRIN (2008): “Modelli matematici per sistemi a molte componenti nelle scienze mediche ed ambientali” (MIUR).
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Fasano, A., Gandolfi, A. (2013). The Steady State of Multicellular Tumour Spheroids: A Modelling Challenge. In: Ledzewicz, U., Schättler, H., Friedman, A., Kashdan, E. (eds) Mathematical Methods and Models in Biomedicine. Lecture Notes on Mathematical Modelling in the Life Sciences. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4178-6_7
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