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Enteroviruses in the Mouse Model of Type 1 Diabetes

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Diabetes and Viruses

Abstract

Findings of pancreatitis in mice after infection with the human enteroviruses coxsackievirus B (CVB) suggested a relationship to the onset of type 1 diabetes (Coleman et al. 1973), a correlation that had been suggested by studies that had variably found a serologic relationship of CVB4 to recent onset diabetic patients (Gamble et al. 1969). Although other enteroviruses may well be involved in induction of pancreatitis and type 1 diabetes (Tracy et al. 2010), the ability of CVBs to use the murine homolog of the coxsackievirus and adenovirus receptor CAR (Bergelson et al. 1997; Carson et al. 1997; Tomko et al. 1997; Bergelson et al. 1998) makes CVB-induced murine pancreatitis and diabetes a model for the human disease.

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Authors and Affiliations

  1. Department of Pathology & Microbiology, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE, 68198-6495, USA

    Nora M. Chapman Ph.D.

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  1. Nora M. Chapman Ph.D.
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Correspondence to Nora M. Chapman Ph.D. .

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Editors and Affiliations

  1. Queen Mary's School of Medicine and Dent, Centre for Diabetes & Metabolic Medicine, Institute of Cell & Molecular Science, n/a, London, E1 2AT, United Kingdom

    Keith Taylor

  2. Tampere University Hospital, Department of Virology, University of Tampere, n/a, Tampere, 33520, Finland

    Heikki Hyöty

  3. University of Insubria & Ospedale di Cir, Varese, Italy

    Antonio Toniolo

  4. University College London Medical School, n/a, London, NW3 2PF, United Kingdom

    Arie J. Zuckerman

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Chapman, N.M. (2013). Enteroviruses in the Mouse Model of Type 1 Diabetes. In: Taylor, K., Hyöty, H., Toniolo, A., Zuckerman, A. (eds) Diabetes and Viruses. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4051-2_6

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