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Introduction to Germ Cell Development in Caenorhabditis elegans

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Germ Cell Development in C. elegans

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 757))

Abstract

A central feature of the continuum of life in sexually reproducing metazoans is the cycle of the germline from one generation to the next. This volume describes the cycle of the germline for Caenorhabditis elegans through chapters that are focused on distinct aspects or processes in germ cell development. Topics include sequential and dependent processes such as specification of germ cells as distinct from somatic cells, sex determination, stem cell proliferative fate versus meiotic development decision, recombination/progression through meiotic prophase, contemporaneous processes such as gametogenesis, meiotic development and apoptosis, and continuing the cycle into the next generation through fertilization and the oocyte-to-embryo transition. Throughout germ cell development, translational control and epigenetic mechanisms play prominent roles. These different aspects of germ cell development are seamlessly integrated under optimal conditions and are modified in the different reproductive strategies that are employed by C. elegans under harsh environmental conditions. In this chapter, we set the stage by providing a brief background on the C. elegans system and germ cell development, indicating processes in the cycle of the germline that are covered in each chapter.

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Acknowledgments

We thank Dave Hansen for comments, and Karen Fiorino for the artwork. Nanette Pazdernik is supported by NIH T32 HD 49305. Research in the Schedl laboratory is supported by R01 GM085150.

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Authors and Affiliations

  1. Department of Genetics, Washington University School of Medicine, 8232, 4566 Scott Avenue, St. Louis, MO, 63110, USA

    Nanette Pazdernik & Tim Schedl

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  1. Nanette Pazdernik
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  2. Tim Schedl
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Correspondence to Tim Schedl .

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  1. , Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St. Louis, 63130, Missouri, USA

    Tim Schedl

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Pazdernik, N., Schedl, T. (2013). Introduction to Germ Cell Development in Caenorhabditis elegans . In: Schedl, T. (eds) Germ Cell Development in C. elegans. Advances in Experimental Medicine and Biology, vol 757. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4015-4_1

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