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Circulating Cell-derived Vesicles Mediate Tumor Progression

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Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication

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Abstract

Tumor cells have been demonstrated to release membranous structures, which are termed as microvesicles or exosomes depending on specific characteristics, including size and composition. These cell-derived vesicles can exhibit an array of proteins, lipids, and nucleic acids derived from the originating tumor. It is now recognized that these vesicular components are critical conveyers of intercellular communication and mediated many of the pathological conditions associated with cancer development, progression, and therapeutic failures. Through the expression of components responsible for angiogenesis promotion, stromal remodeling, signaling pathway activation through growth factor/receptor transfer, chemoresistance, and genetic intercellular exchange, tumor exosomes/microvesicles could represent a central mediator of the tumor microenvironment.

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Authors and Affiliations

  1. Division of Gynecologic Oncology, James Graham Brown Cancer Center, 505 South Hancock Street, CTRB 316, 40202, Louisville, KY, USA

    Douglas D. Taylor

  2. Department of Obstetrics, Gynecology, and Women’s Health, University of Louisville School of Medicine, 40202, Louisville, KY, USA

    Gercel-Taylor Cicek

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  1. Douglas D. Taylor
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  2. Gercel-Taylor Cicek
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Correspondence to Douglas D. Taylor .

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  1. , James Brown Cancer Center, University of Louisville, 505 S. Hancock Street, Louisville, 40202, Kentucky, USA

    Huang-Ge Zhang

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Taylor, D., Cicek, GT. (2013). Circulating Cell-derived Vesicles Mediate Tumor Progression. In: Zhang, HG. (eds) Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3697-3_6

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