Abstract
Genetic variation at the genome level, and consequently phylogenetic relationship, has been well studied in the closely related human pathogens Yersinia pseudotuberculosis and Yersinia pestis. In contrast the remaining pathogenic species of the genus, Yersinia enterocolitica is relatively poorly understood, with only one genome sequence available from a biotype of the species rarely isolated from humans or animals worldwide. In this study we present a reference genome sequence for each of the Y. enterocolitica biotypes, and discuss comparative genomics across the species. In addition we also present phylogenetic data for the species, and its position with the wider genus, based on genome sequences of 100 Y. enterocolitica strains. The study provides new and exciting insights into the evolution of pathogenesis in the Yersinia genus, and in particular of the Y. enterocolitica species.
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Acknowledgements
We would like to thank Mark Achtman for efforts in collating a collection of strains, and all those who contributed to that collection, particularly Thilo Fuchs, Elisabeth Carniel, and Muriel DuFour. This work was funded by a VC studentship awarded to SR and AM, and by the Wellcome Trust Sanger Institute.
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Reuter, S., Thomson, N.R., McNally, A. (2012). Evolutionary Dynamics of the Yersinia enterocolitica Complex. In: de Almeida, A., Leal, N. (eds) Advances in Yersinia Research. Advances in Experimental Medicine and Biology, vol 954. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3561-7_2
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DOI: https://doi.org/10.1007/978-1-4614-3561-7_2
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