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Primate Short-Wavelength Cones Share Molecular Markers with Rods

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Retinal Degenerative Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 801))

Abstract

Macaca, Callithrix jacchus marmoset monkey, Pan troglodytes chimpanzee and human retinas were examined to define if short wavelength (S) cones share molecular markers with L&M cone or rod photoreceptors. S cones showed consistent differences in their immunohistochemical staining and expression levels compared to L&M cones for “rod” Arrestin1 (S-Antigen), “cone” Arrestin4, cone alpha transducin, and Calbindin. Our data verify a similar pattern of expression in these primate retinas and provide clues to the structural divergence of rods and S cones versus L&M cones, suggesting S cone retinal function is “intermediate” between them.

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Abbreviations

Arr:

Arrestin

Calb:

Calbindin

CTr:

Cone Transducin

IHC:

Immunohistochemistry

S:

Short wavelength

M:

Medium wavelength

L:

Long wavelength

RTr:

Rod Transducin

Mab:

Monoclonal

Pab:

Polyclonal

OS:

Outer segment

NRL:

Neural retina leucine zipper

NR2E3:

Nuclear receptor subfamily 2, group E, member 3

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Acknowledgments

Dr. Craft holds the Mary D. Allen Chair in Vision Research, Doheny Eye Institute. We thank Drs. Donoso, MacLeisch, Nathans, and Saari for generously providing antibodies. This work was supported, in part, by EY015851 (CMC), Kayser Award (AH), CORE grants EY01730 (UW) and EY03040 (DEI), and Research to Prevent Blindness. We gratefully acknowledge the assistance of the Willed Body Program and the Tissue Programs at University of Washington, University of Wisconsin Regional Primate Research Center (P51RR000167), San Antonio Primate Center (P51-RR13986), and Yerkes Regional Primate Center.

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Authors and Affiliations

  1. Mary D. Allen Laboratory for Vision Research, Doheny Eye Institute, Departments of Ophthalmology and Cell & Neurobiology, Keck School of Medicine of the University of Southern California, 1355 San Pablo St., DVRC 405, 90033, Los Angeles, CA, USA

    Dr. Cheryl M. Craft

  2. Department of Ophthalmology, University of Washington, 98195, Seattle, WA, USA

    Jing Huang, Daniel E. Possin & Anita Hendrickson

  3. Department of Biological Structure, University of Washington, 98195, Seattle, WA, USA

    Anita Hendrickson

Authors
  1. Dr. Cheryl M. Craft
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  2. Jing Huang
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  3. Daniel E. Possin
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  4. Anita Hendrickson
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Corresponding author

Correspondence to Cheryl M. Craft .

Editor information

Editors and Affiliations

  1. Department of Ophthalmology, University of Florida, Gainesville, Florida, USA

    John D. Ash

  2. University Hospital Zurich, Zurich, Switzerland

    Christian Grimm

  3. Cole Eye Institute at the Cleveland Clin Division of Ophthalmology, Cleveland, Ohio, USA

    Joe G. Hollyfield

  4. Dean A. McGee Eye Inst., University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA

    Robert E. Anderson

  5. Beckman Vision Center, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Matthew M. LaVail

  6. Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    Catherine Bowes Rickman

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Craft, C., Huang, J., Possin, D., Hendrickson, A. (2014). Primate Short-Wavelength Cones Share Molecular Markers with Rods. In: Ash, J., Grimm, C., Hollyfield, J., Anderson, R., LaVail, M., Bowes Rickman, C. (eds) Retinal Degenerative Diseases. Advances in Experimental Medicine and Biology, vol 801. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3209-8_7

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  • DOI: https://doi.org/10.1007/978-1-4614-3209-8_7

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-3208-1

  • Online ISBN: 978-1-4614-3209-8

  • eBook Packages: MedicineMedicine (R0)

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