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Design and Engineering of Multifunctional Quantum Dot-Based Nanoparticles for Simultaneous Therapeutic-Diagnostic Applications

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Multifunctional Nanoparticles for Drug Delivery Applications

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

Quantum dots (QD) are semiconducting nanocrystals that have recently received a lot of interest because of their efficacy as fluorescent probes. They offer a significant increase in photostability and fluorescence lifetime compared to more traditional organic dye-based probes; however, some concern from their potential in vivo use due to their chemical composition and their nanoscale dimensions exists. Within this chapter, we discuss current knowledge about the fluorescence properties and pharmacological profile of quantum dots, showing how these characteristics can be altered after incorporation within previously established drug delivery systems for the formation of novel hybrid systems. The incorporation of therapeutic agents into such hybrid systems can further result in the construction of theranostic devices, namely, QD-based theranostics. Alternatively, conjugation of quantum dots to therapeutic moieties can be used as a scaffold for theranostic device design. This chapter will discuss the current progress in QD-based theranostics.

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Authors and Affiliations

  1. Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, UK

    Bowen Tian, Wafa’ T. Al-Jamal, Jeroen Van den Bossche & Kostas Kostarelos

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  1. Bowen Tian
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  2. Wafa’ T. Al-Jamal
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  3. Jeroen Van den Bossche
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  4. Kostas Kostarelos
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  1. Drug Delivery Solutions LLC, Temple Street 16, Arlington, 02476, Massachusetts, USA

    Sonke Svenson

  2. Princeton University, n/a, Princeton, 08544, USA

    Robert K. Prud'homme

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Tian, B., Al-Jamal, W.T., Van den Bossche, J., Kostarelos, K. (2012). Design and Engineering of Multifunctional Quantum Dot-Based Nanoparticles for Simultaneous Therapeutic-Diagnostic Applications. In: Svenson, S., Prud'homme, R. (eds) Multifunctional Nanoparticles for Drug Delivery Applications. Nanostructure Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2305-8_16

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