Abstract
This chapter focuses on the state of the art in the field of nanorobotics by presenting a brief historical overview, the various types of nanorobotic systems, their applications, and future directions in this field. Nanorobots are basically any type of active structure capable of any one of the following (or any of their combination): actuation, sensing, manipulation, propulsion, signaling, information processing, intelligence, and swarm behavior at the nanoscale (10−9 m). The following four types of nanorobotic systems have been developed and studied so far (a) large size nanomanipulators with nanoscale manipulation capability; (b) protein- and DNA-based bionanorobotic systems; (c) magnetically guided nanorobotic systems; and (d) bacterial-based nanorobotics. Nanorobotic systems are expected to be used in many different areas that range from medical to environmental sensing to space and military applications. From precise drug delivery to repairing cells and fighting tumor cells, nanorobots are expected to revolutionize the medical industry in the future.
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References
Requicha AAG, Baur C, Bugacov A, Gazen BC, Koel B, Madhukar A, Ramachandran TR, Resch R, Will P (1998) Nanorobotic assembly of two-dimensional structures. In: Proceedings of the IEEE international conference on robotics and automation, Leuven, Belgium, 16–21 May 1998, pp 3368–3374
Sitti M, Hashimoto H (1998) Tele-nanorobotics using atomic force microscope. In: Proceedings of the IEEE/RSJ international conference on intelligent robots and systems, IROS’98, Victoria, Canada, October, pp 1739–1746
Freitas RA Jr (1999) Nanomedicine, volume I: basic capabilities. Landes Bioscience, Georgetown, TX, http://www.nanomedicine.com/NMI.htm
Wowk B (1988) Cell repair technology. Cryonics Magazine, Alcor Foundation Reprint, pp 7–10
Dewdney AK (1988) Nanotechnology – wherein molecular computers control tiny circulatory submarines. Sci Am 258(101):100–103
Drexler KE (1986) Engines of creation: the coming era of nanotechnology. Anchor, New York
Drexler KE, Peterson C, Pergamit G (1991) Unbounding the future: the nanotechnology revolution. William Morrow, New York
Drexler KE (1992) Nanosystems: molecular machinery, manufacturing, and computation. Wiley, New York
Freitas RA Jr (2003) Nanomedicine, volume IIA: biocompatibility. Landes Bioscience, Georgetown, TX, http://www.nanomedicine.com/NMIIA.htm
Freitas RA Jr (2005) Current status of nanomedicine and medical nanorobotics. J Comput Theor Nanosci 2:1–25
Asimov I (1966) Fantastic voyage. Houghton Mifflin, Boston, MA
Crichton M (2002) Prey. Avon, New York
Weir NA, Sierra DP, Jones JF (2005) A review of research in the field of nanorobotics. Sandia National Laboratories Report SAND2005-6808. http://prod.sandia.gov/techlib/access-control.cgi/2005/056808.pdf
Ummat A, Dubey A, Sharma G, Mavroidis C (2006) Bio-nano-robotics: state of the art and future challenges (chapter 19, invited chapter). In: Bronzino JD (ed) Tissue engineering and artificial organs, The biomedical engineering handbook. CRC, Boca Raton, FL. ISBN 0849321239
Vartholomeos P, Fruchard M, Ferreira A, Mavroidis C (2010) MRI-guided nanorobotic systems for drug delivery (chapter 45). In: Klaus S (ed) Handbook of nano-physics, vol 7. Taylor & Francis, Boca Raton, FL. ISBN 978-1-4200753-8-0
Bonabeau E, Dorigo M, Theraulaz G (1999) Swarm intelligence: from natural to artificial systems. Oxford University Press, New York
Arbuckle DJ, Requicha AAG (2010) Self-assembly and self-repair of arbitrary shapes by a swarm of reactive robots: algorithms and simulations. Auton Robot 28(2):197–211
Freitas RA Jr, Merkle RC (2004) Kinematic self-replicating machines. Landes Bioscience, Georgetown, TX, http://www.MolecularAssembler.com/KSRM.htm
Ummat A, Dubey A, Mavroidis C, Mavroidis C (2010) Bionanorobotics: a field inspired by nature (chapter 7, invited chapter). In: Bar-Cohen Y (ed) Biomimetics – biologically inspired technologies. CRC, Boca Raton, FL, pp 201–227. ISBN 0849331633
Ferreira A, Mavroidis C (2006) Virtual reality and haptics in nano robotics: a review study. IEEE Robot Autom Mag 13(2):78–92
Freudenstein F (1973) Kinematics: past, present and future. Mech Mach Theory 8:151–160
Cray D (2000) Incredible shrinking doctors. Pop Sci July:63–65
Stroscio JA, Eigler DM (1991) Atomic and molecular manipulation with the scanning tunneling microscope. Science 254(5036):1319–1326
Eigler DM, Schweizer EK (1990) Positioning single atoms with a scanning tunneling microscope. Nature 344:524–526
Requicha AA (1999) Nanorobotics. In: Shimon YN (ed) Handbook of industrial robotics. Wiley, New York
Dong LX, Arai F, Fukuda T (2001) 3-D nanorobotic manipulation of nanometer-scale objects. J Robot Mechatron 13(2):146–153
Fukuda T, Arai F, Dong L (2003) Assembly of nanodevices with carbon nanotubes through nanorobotic manipulation. Proc IEEE 91(11):1803–1818
Fukuda T, Arai F, Dong LX (2005) Nanorobotic systems. Int J Adv Robot Syst 2(3):264–275
Du E, Cui H, Zhu Z (2006) Review of nanomanipulators for nanomanufacturing. Int J Nanomanufacturing 1(1):83–104
Dong LX, Nelson BJ (2007) Robotics in the small, part II: nanorobotics. IEEE Robot Autom Mag 14(3):111–121
Dong LX, Subramanian A, Nelson BJ (2007) Carbon nanotubes for nanorobotics. Nano Today 2(6):12–21
Dubey A, Mavroidis C, Thornton A, Nikitczuk KP, Yarmush ML (2003) Viral protein linear (VPL) nano-actuators. In: Proceedings of the 2003 IEEE – NANO conference, San Francisco, CA, 12–14 August 2003, vol 2, pp 140–143
Dubey A, Sharma G, Mavroidis C, Tomassone SM, Nikitczuk KP, Yarmush ML (2004) Dynamics and kinematics of viral protein linear nano-actuators for bio-nano robotic systems. In: Proceedings of the 2004 IEEE international conference of robotics and automation, New Orleans, LA, 26 April–1 May 2004, pp 1628–1633
Mavroidis C, Dubey A, Yarmush M (2004) Molecular machines. Annu Rev Biomed Eng 6:363–395
Sherman WB, Seeman NC (2004) A precisely controlled DNA bipedal walking device. Nano Lett 4:1203–1207
Montemagno CD, Bachand GD (1999) Constructing nanomechanical devices powered by biomolecular motors. Nanotechnology 10:225–331
Bachand GD, Montemagno CD (2000) Constructing organic/inorganic NEMS devices powered by biomolecular motors. Biomed Microdevices 2:179–184
Yurke B, Turberfield AJ, Mills AP Jr, Simmel FC, Neumann JL (2000) A DNA-fuelled molecular machine made of DNA. Nature 406:605–608
Douglas SM, Bachelet I, Church GM (2012) A logic-gated nanorobot for targeted transport of molecular payloads. Science 335(6070):831–834
Hamdi M, Ferreira A, Sharma G, Mavroidis C (2008) Prototyping bio-nanorobots using molecular dynamics simulation and virtual reality. Microelectron J 30(2):190–201
Dubey A, Mavroidis C, Tomassone SM (2006) Molecular dynamic studies of viral-protein based nano-actuators. J Comput Theor Nanosci 3(6):885–897
Sharma G, Rege K, Budil D, Yarmush M, Mavroidis C (2008) Reversible pH-controlled DNA binding peptide nano-tweezers – an in-silico study. Int J Nanomed 3(4):505–521
Sharma G, Rege K, Budil D, Yarmush M, Mavroidis C (2009) Computational studies of a protein based nanoactuator for nanogripping applications. Int J Robot Res 28(4):421–435
Sharma G, Rege K, Budil D, Yarmush M, Mavroidis C (2009) Biological force measurement in a protein based nano-actuator. IEEE Trans Nanotechnol 8(6):684–691
Gullà S, Sharma G, Borbat P, Freed J, Ghimire H, Lorigan G, Rege K, Mavroidis C, Budil D (2009) Molecular-scale force measurement in a coiled-coil peptide by electron spin resonance. J Am Chem Soc 131(15):5374–5375
Hamdi M, Ferreira A (2009) Multiscale design and modeling of protein-based nanomechanisms for nanorobotics. Int J Robot Res 28:436–449
Ferreira A, Sharma G, Mavroidis C (2005) New trends in bio-nanorobotics using virtual reality technologies. In: Proceedings of the IEEE international conference on robotics and biomimetics (IEEE ROBIO 2005), Hong Kong SAR and Macau SAR, China, 29 June–03 July 2005, pp 89–94
Hamdi M, Sharma G, Ferreira A, Mavroidis C (2005) Molecular mechanics simulation of bionanorobotic components using force feedback. In: Proceedings of the IEEE international conference on robotics and biomimetics (IEEE ROBIO 2005), Hong Kong SAR and Macau SAR, China, 29 June–03 July 2005, pp 105–110
Hamdi M, Sharma G, Ferreira A, Mavroidis C (2006) Characterization of protein based spring-like elastic joints for biorobotic applications. In: Proceedings of the 2006 IEEE international conference on robotics and automation, Orlando, FL, 15–19 May 2006
Hamdi M, Ferreira A (2008) DNA nanorobotics. Microelectron J 39:1051–1059
Vartholomeos P, Fruchard M, Ferreira A, Mavroidis C (2011) MRI-guided nanorobotic systems for therapeutic and diagnostic applications. Annu Rev Biomed Eng 13:157–184
Martel S, Mathieu JB, Felfoul O, Chanu A, Aboussouan E, Tamaz S, Pouponneau P, Yahia L, Beaudoin G, Soulez G, Mankiewicz M (2008) A computer-assisted protocol for endovascular target interventions using a clinical MRI system for controlling untethered microdevices and future nanorobots. Comput Aided Surg 13(06):340–352
Mathieu J-B, Beaudoin G, Martel S (2006) Method of propulsion of a ferromagnetic core in the cardiovascular system through magnetic gradients generated by an MRI system. IEEE Trans Biomed Eng 53:292–299
Mathieu J-B, Martel S (2007) Magnetic microparticle steering within the constraints of an MRI system: proof of concept of a novel targeting approach. Biomed Microdevices 9:801–808
Martel S, Mathieu J-B, Felfoul O, Chanu A, Aboussouan E, Tamaz S, Pouponneau P, Beaudoin G, Soulez G, L’H Y, Mankiewicz M (2007) Automatic navigation of an untethered device in the artery of a living animal using a conventional clinical magnetic resonance imaging system. Appl Phys Lett 90:114105–114108
Zeeshan M, Shou K, Pané S, Pellicer E, Sort J, Sivaraman K, Baró MD, Nelson BJ (2011) Structural and magnetic characterization of batch-fabricated nickel encapsulated multi-walled carbon nanotubes. Nanotechnology 22:275713
Folio D, Dahmen C, Wortmann T, Zeeshan M, Shou K, Pane S, Nelson BJ, Ferreira A, Fatikow S (2011) MRI magnetic signature imaging, tracking and navigation for targeted micro/nano capsule therapeutics. In: IEEE international conference on intelligent robots and systems, San Francisco, 23–29 September 2011
Arcese L, Fruchard M, Ferreira A (2012) Endovascular magnetically-guided robots: navigation, modeling and optimization. IEEE Trans Biomed Eng 59(4):977–987
Belharet K, Folio D, Ferreira A (2011) Three dimensional controlled motion of a microrobot using magnetic gradients. Adv Robot 25:1069–1083
Wortmann T, Dahmen C, Fatikow S (2010) Study of MRI susceptibility artifacts for nanomedical applications. ASME J Nanotechnol Eng Med 1(4):041002
Kummer MP, Abbott JJ, Kratochvil BE, Borer R, Sengul A, Nelson BJ (2010) OctoMag: an electromagnetic system for 5-DOF wireless micromanipulation. IEEE Trans Robot 26(6):1006–1017
Schürle S, Peyer KE, Kratochvil BE, Nelson BJ (2012) Holonomic 5-DOF magnetic control of 1D nanostructures. In: Proceedings of the 2012 IEEE international conference on robotics and automation, Minnesota, pp 1081–1086
Sitti M (2009) Miniature devices: voyage of the microrobots. Nature 458:1121–1122
Berry RM, Armitage JP (1999) The bacterial flagella motor. Adv Microb Physiol 41:291–337
Berg HC (2003) The rotary motor of bacterial flagella. Annu Rev Biochem 72:19–54
Berg HC, Anderson RA (1973) Bacteria swim by rotating their flagellar filaments. Nature 245:380–382
Darnton N, Turner L, Breuer K, Berg HC (2004) Moving fluid with bacterial carpet. Biophys J 86:1863–1870
Steager E, Kim C-B, Patel J, Bith S, Naik C, Reber L, Kim MJ (2007) Control of microfabricated structures powered by flagellated bacteria using phototaxis. Appl Phys Lett 90:263901–263903
Behkam B, Sitti M (2007) Bacterial flagella-based propulsion and on/off motion control of microscale objects. Appl Phys Lett 90:023902–023904
Behkam B, Sitti M (2008) Effect of quantity and configuration of attached bacteria on bacterial propulsion of microbeads. Appl Phys Lett 92:223901
Ardelean I, Ignat M, Moisescu C (2007) Magnetotactic bacteria and their significance for P systems and nanoactuators. In: Gutierrez-Naranjo MA, Paun G, Romero-Jimenez A, Riscos-Nunez A (eds) Proceedings of the 5th brainstorming week on membrane computing, Seville, pp 21–32
Martel S, Tremblay C, Ngakeng S, Langlois G (2006) Controlled manipulation and actuation of microobjects with magnetotactic bacteria. Appl Phys Lett 89:233804–233806
Martel S, Mohammadi M, Felfoul O, Lu Z, Pouponneau P (2009) Flagellated magnetotactic bacteria as controlled MRI-trackable propulsion and steering systems for medical nanorobots operating in the human microvasculature. Int J Robot Res 28:571–582
Dreyfus R, Baudry J, Roper ML, Fermigier M, Stone HA, Bibette J (2005) Microscopic artificial swimmers. Nature 437:862–865
Zhang L, Abbott JJ, Dong LX, Peyer KE, Kratochvil BE, Zhang HX, Bergeles C, Nelson BJ (2009) Characterizing the swimming properties of artificial bacterial flagella. Nano Lett 9(10):3663–3667
Zhang L, Peyer KE, Nelson BJ (2010) Artificial bacterial flagella for micromanipulation. Lab Chip 10:2203–2215
Xi N, Fung WK, Yu M, Li G (2005) Augmenting reality system for real-time nanomanipulation using atomic force microscopy. US Patent 6,862,924, 8 Mar 2005
Solomon N (2011) System, methods and apparatuses for integrated circuits for nanorobotics. US Patent 7,921,384, 5 Apr 2011
Jonckheere E, Lou M (2012) Spinal injury imaging by magnetically levitated sensors. US Patent 8,200,310, 12 June 2012
Martel S, Mathieu JB, Yahia L’H, Soulez G, Beaudoin G (2011) Method and system for propelling and controlling displacement of a microrobot in a blood vessel. US Patent 7,962,194, 14 June 2011
Cavalcanti A, Shirinzadeh B, Fukuda T, Ikeda S (2009) Nanorobot for brain aneurysm. Int J Robot Res 28(4):558–570
Cavalcanti A, Shirinzadeh B, Kretly LC (2008) Medical nanorobotics for diabetes control. Nanomedicine 4(2):127–138
Cavalcanti A, Shirinzadeh B, Zhang M, Kretly LC (2008) Nanorobot hardware architecture for medical defense. Sensors 8(5):2932–2958
Cavalcanti A, Shirinzadeh B, Freitas RA Jr, Hogg T (2008) Nanorobot architecture for medical target identification. Nanotechnology 19(1):015103 (15pp)
Tabatabaei SN, Duchemin S, Girouard H, Martel S (2012) Towards MR-navigable nanorobotic carriers for drug delivery into the brain. In: Proceedings of the 2012 IEEE international conference on robotics and automation, Minnesota, pp 727–732
Bergeles C, Shamaei KG, Abbott JJ, Nelson BJ (2010) Single-camera focus-based localization of intraocular devices. IEEE Trans Biomed Eng 57(8):2064–2074
Bergeles C, Kratochvil BE, Nelson BJ (2012) Visually servoing magnetic intraocular microdevices. IEEE Trans Robot. doi:10.1109/TRO.2012.2188165
Clark S (2012) Nanotechnology can launch a new age of space exploration. The Guardian (UK), 17 Apr 2012
Chui B, Kissner L (2000) Nanorobots for Mars EVA Repair. In: Proceedings of the international conference on environmental systems, Toulouse. doi: 10.4271/2000-01-2478
Mavroidis C, Ummat A (2005) Space bionanorobotic systems: design and applications. In: Proceedings of the 7th NASA/DoD conference on evolvable hardware (EH-2005), Washington, DC, 29 June–1 July 2005
Mavroidis C (2006) Bionano machines for space applications. Final Phase II Report to the NASA Institute of Advanced Concepts, July 2006. http://www.coe.neu.edu/Research/robots/papers/NIAC06.pdf
Sanni M, Kamal R, Kanj MY (2008) Reservoir nanorobots. Saudi Aramco J Technol Spring:44–52
Saudi Aramco (2012) Resbots reservoir robots. http://www.saudiaramco.com/content/mobile/en/home/innovation2/innovation-at-saudi-aramco/resbots-reservoir-robots.html?switchToMobile=1
Feynman RP (1959) Plenty of room at the bottom. California Institute of Technology. http://www.its.caltech.edu/~feynman/plenty.html
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Mavroidis, C., Ferreira, A. (2013). Nanorobotics: Past, Present, and Future. In: Mavroidis, C., Ferreira, A. (eds) Nanorobotics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2119-1_1
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