Abstract
On the basis of solubility, foreign compounds that humans ingest or inhale can be classified into two categories. One class of foreign compounds is soluble in water (hydrophilic), but not in lipid medium. Another class is soluble in lipid medium (lipophilic), but not in water. Lipophilic substances require enzymatic conversion into hydrophilic, polar species before being excreted in the urine. The more lipophilic a foreign compound is, the more difficult it becomes for excretion via the kidney. Hydrophilic compounds can be excreted in the urine without enzymatic conversion to increase their solubility.
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Chen, CH. (2012). Lipophilic Foreign Compounds. In: Activation and Detoxification Enzymes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1049-2_2
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DOI: https://doi.org/10.1007/978-1-4614-1049-2_2
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