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Catalytic Reactions of Phase II Enzymes

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Activation and Detoxification Enzymes

Abstract

After the functional groups catalyzed by phase I activation enzymes are introduced, lipophilic foreign compounds undergo phase II enzyme-catalyzed reactions, which result in greatly increasing the solubility of parent compounds, thus facilitating their excretion from the body. Foreign compounds that already contain such functional groups can proceed with phase II metabolism without undergoing functionalization reactions. Though phase II reactions are a major defense mechanism, in some cases, the formed conjugates undergo further reactions to yield unstable, reactive metabolites.

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Authors and Affiliations

  1. Department of Biomedical Sciences, University at Albany, State University of New York, Albany, NY, USA

    Chang-Hwei Chen Ph.D. (Professor, Institute for Health and the Environment Former Professor)

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  1. Chang-Hwei Chen Ph.D.
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Correspondence to Chang-Hwei Chen Ph.D. .

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Chen, CH. (2012). Catalytic Reactions of Phase II Enzymes. In: Activation and Detoxification Enzymes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1049-2_15

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