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Preclinical Studies Using Mouse Models of Inflammatory Bowel Disease

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Crohn's Disease and Ulcerative Colitis

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Abstract

Most therapeutic agents used in clinical practice today were originally developed and tested in animal models so that drug toxicity and safety, dose–responses, and efficacy could be determined. Retrospective analyses of preclinical intervention studies using animal models of different diseases demonstrate that only a small percentage of the interventions reporting promising effects translate to clinical efficacy. It is becoming increasingly appreciated that the failure to translate therapeutic efficacy from bench to bedside may be due, in part, to selection of an animal model that may not recapitulate the immunopathologic features of the human disease under investigation. This is especially true for preclinical investigations using mouse models of the inflammatory bowel diseases (IBD; Crohn’s disease, ulcerative colitis). One potential strategy for improving our ability to discover new therapeutics that may have a reasonable chance of success in clinical trials is to identify the most immunologically relevant mouse models of human IBD. This chapter presents a critical evaluation of the different mouse models of IBD and discusses their utility in preclinical studies.

*Contributed equally to the preparation of the manuscript.

Much of this chapter was reproduced from a review entitled “Pharmacological Intervention Studies Using Mouse Models of the Inflammatory Bowel Diseases: Translating Preclinical Data into New Drug Therapies” published in Inflammatory Bowel Diseases, 2011 May;17(5):1229– 45. [This material is reproduced with permission from John Wiley and Sons, Inc.]

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Acknowledgments

Some of the work reported in this manuscript was supported by a grant from the NIH (PO1-DK43785, Project 1, Animal Models Core and Histopathology Core).

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  1. Immunology and Inflammation Research Group, Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, 71130, USA

    Fridrik Karlsson PhD., Iurii Koboziev BS & Matthew B. Grisham PhD

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Correspondence to Matthew B. Grisham PhD .

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  1. Medical School of the Humboldt Universit, Department of Medicine, Charité Medical Center, Virchow Hospita, Berlin, 13344, Germany

    Daniel C. Baumgart

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Karlsson, F., Koboziev, I., Grisham, M.B. (2012). Preclinical Studies Using Mouse Models of Inflammatory Bowel Disease. In: Baumgart, D. (eds) Crohn's Disease and Ulcerative Colitis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0998-4_16

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