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Neurological Effects and Cognitive Development

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Pediatric Dialysis

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Abstract

Children and adult survivors of childhood-onset end stage kidney disease (ESKD) have a greater frequency of neurodevelopmental and cognitive challenges compared with the general population [1, 2]. The impact of this neurodevelopmental vulnerability persists into adulthood and contributes to manifestations such as a lower intelligence quotient (IQ) and lower frequency of post-secondary education compared with the general population [2]. The mechanisms responsible for the brain dysfunction observed with ESKD have not been established. The goals of this chapter are to review the acute neurologic complications of dialysis and to explore potential mechanisms leading to brain dysfunction, summarize known neurocognitive and neurologic findings, and consider possible management strategies for cognitive dysfunction in children affected by ESKD.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA

    Debbie S. Gipson MD

  2. Carolina Institute for Developmental Diabilities, University of North Carolina School of Medicine, Chapel Hill, NC, USA

    Stephen R. Hooper PhD

Authors
  1. Debbie S. Gipson MD
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  2. Stephen R. Hooper PhD
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Correspondence to Debbie S. Gipson MD .

Editor information

Editors and Affiliations

  1. Children’s Mercy Hospital and Clinics, Department of Pediatrics, Section of Pediatric Nephrology, School of Medicine, Kansas City, 64108, Missouri, USA

    Bradley A. Warady

  2. Center for Pediatrics, and Adolescent Medicine, Division of Pediatric Nephrology, Im Neuenheimer Feld 150, Heidelberg, 69120, Germany

    Franz Schaefer

  3. Department of Pediatrics, Stanford University School of Medicine, Division of Pediatric Nephrology, Welch Road 770, Palo Alto, 94304, California, USA

    Steven R. Alexander

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Gipson, D.S., Hooper, S.R. (2012). Neurological Effects and Cognitive Development. In: Warady, B., Schaefer, F., Alexander, S. (eds) Pediatric Dialysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0721-8_29

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  • DOI: https://doi.org/10.1007/978-1-4614-0721-8_29

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