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Insulin-Like Growth Factor Signaling in Pediatric Sarcomas

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Insulin-like Growth Factors and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Uncontrolled cell growth is central to carcinogenesis. Growth factors, as well as growth factor-initiated pathways, that regulate cell growth control and also modulate cell phenotype are undoubtedly important to the etiology of cancer. Research on cancer biology and cellular signaling mediated by the family of insulin/insulin-like growth factor (IGF) receptors and their cognate ligands have been ongoing for over three decades. The excitement and attention focused on the IGF system has recently turned to targeting insulin-like growth factor receptor 1 (IGF-1R) using humanized and fully human antibodies. The use of this approach in clinical trials has resulted in several dramatic responses in patients with recurrent and refractory pediatric sarcomas. This chapter focuses on highlights in the biological, therapeutic, preclinical, and clinical roles of the IGF family in pediatric sarcomas.

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Authors and Affiliations

  1. Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA

    Xiaolin Wan, Su Young Kim & Lee J. Helman

Authors
  1. Xiaolin Wan
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  2. Su Young Kim
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  3. Lee J. Helman
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Correspondence to Lee J. Helman .

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Editors and Affiliations

  1. , Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, NEW YORK, 10029, USA

    Derek LeRoith

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Wan, X., Kim, S.Y., Helman, L.J. (2012). Insulin-Like Growth Factor Signaling in Pediatric Sarcomas. In: LeRoith, D. (eds) Insulin-like Growth Factors and Cancer. Cancer Drug Discovery and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0598-6_7

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  • DOI: https://doi.org/10.1007/978-1-4614-0598-6_7

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  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4614-0597-9

  • Online ISBN: 978-1-4614-0598-6

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