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Topological Characteristics of Molecular Networks

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Functional Coherence of Molecular Networks in Bioinformatics

Abstract

We present currently available computational methods for graph-theoretic analysis, modeling, and comparison of biological networks. Biological network research is still in its infancy, since the current data is of low quality, and since the existing methods for their analyses are relatively crude, owing to the computational intractability of many graph theoretic problems. Nonetheless, the field has already provided valuable insights into biological function, evolution, and disease. Further systems-level analyses of cellular inter-connectedness have an enormous potential to lead to new interesting biological discoveries and give novel insights into organizational principles of life and therapeutics, thus potentially having huge impacts on public health. The impact of the field of biological network research is likely to increase with the growth of available biological network data of high quality, as well as with improvements of network analysis and modeling methods. The field is likely to stay at the forefront of scientific research in the years to come.

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Notes

  1. 1.

    http://www.yeastgenome.org/.

  2. 2.

    http://dip.doe-mbi.ucla.edu/.

  3. 3.

    http://www.hprd.org/.

  4. 4.

    http://www.thebiogrid.org/.

  5. 5.

    http://www.ics.uci.edu/\~bio-nets/graphcrunch/.

  6. 6.

    http://www.ics.uci.edu/\~bio-nets/graphcrunch/.

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  1. Department of Computer Science and Engineering, University of Notre Dame, Notre Dame, IN, 46556, USA

    Tijana Milenković

  2. Imperial College London, Exhibition Rd, London, SW7 2AZ, UK

    Nataša Pržulj

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    Mehmet Koyutürk

  2. Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr., La Jolla, 92093-0412, California, USA

    Shankar Subramaniam

  3. Department of Computer Science, Purdue University, 305 North University Street, West Lafayette, 47907-2107, Indiana, USA

    Ananth Grama

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Milenković, T., Pržulj, N. (2012). Topological Characteristics of Molecular Networks. In: Koyutürk, M., Subramaniam, S., Grama, A. (eds) Functional Coherence of Molecular Networks in Bioinformatics. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0320-3_2

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