Skip to main content
SpringerLink
Log in

Intraoperative Evaluation of Primary Hepatocellular Tumors

  • Chapter
  • First Online:
Frozen Section Library: Liver, Extrahepatic Biliary Tree and Gallbladder

Part of the book series: Frozen Section Library ((FROZEN))

  • 1255 Accesses

Abstract

Pathologists may be asked to perform intraoperative evaluation of primary hepatocellular tumors to (1) establish a diagnosis, (2) assess surgical resection margins, and (3) determine whether donor livers that contain nodules are suitable for transplantation. Most hepatocellular tumors detected in nondonor livers are similarly treated with excision, although focal nodular hyperplasia and fibrolamellar hepatocellular carcinoma represent exceptions to this rule. The purpose of this chapter is to discuss features that aid distinction between different types of hepatocellular lesions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cabibbo G, Craxi A. Needle track seeding following percutaneous procedures for hepatocellular carcinoma. World J Hepatol. 2009;31(1):62–6.

    Article  Google Scholar 

  2. Liu C, Frilling A, Dereskewitz C, et al. Tumor seeding after fine needle aspiration biopsy and percutaneous radiofrequency thermal ablation of hepatocellular carcinoma. Dig Surg. 2003;20:460–3.

    Article  Google Scholar 

  3. Chang S, Kim SH, Lim HK, et al. Needle tract implantation after percutaneous interventional procedures in hepatocellular carcinomas: lessons learned from a 10-year experience. Korean J Radiol. 2008;9(3):268–74.

    Article  PubMed  Google Scholar 

  4. Silva MA, Hegab B, Hyde C, Guo G, Buckels JA, Mirza DF. Needle track seeding following biopsy of liver lesions in the diagosis of hepatocellular cancer: a systematic review and meta-analysis. Gut. 2008;57(11):1592–6.

    Article  PubMed  CAS  Google Scholar 

  5. Cha CH, Saif MW, Yamane BH, Weber SM. Hepatocellular carcinoma: current management. Curr Probl Surg. 2010;47(1):10–67.

    Article  PubMed  Google Scholar 

  6. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics 2009. CA Cancer J Clin. 2009;59(4):225–49.

    Article  PubMed  Google Scholar 

  7. El-Serag H, Mason AC, Key C. Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United States. Hepatology. 2001;33(1):62–5.

    Article  PubMed  CAS  Google Scholar 

  8. El-Serag H. Epidemiology of hepatocellular carcinoma in USA. Hepatology. 2007;37 Suppl 2:S88–94.

    Google Scholar 

  9. Tsim NC, Frampton AE, Habib NA, Jiao LR. Surgical treatment for liver cancer. World J Gastroenterol. 2010;16(8):927–33.

    Article  PubMed  Google Scholar 

  10. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. New Engl J Med. 1996;334:693–700.

    Article  PubMed  CAS  Google Scholar 

  11. Grazioli L, Federle MP, Ichikawa T, et al. Liver adenomatosis: clinical, histopathologic, and imaging findings in 15 patients. Radiology. 2000;216:395–402.

    PubMed  CAS  Google Scholar 

  12. Foster JH, Donohue TA, Berman MM. Familial liver-cell adenomas and diabetes mellitus. N Engl J Med. 1978;299:239–41.

    Article  PubMed  CAS  Google Scholar 

  13. Labrune P, Trioche P, Duvaltier I, et al. Hepatocellular adenomas in glycogen storage disease type I and III: a series of 43 patients and review of the literature. J Pediatr Gastroenterol Nutr. 1997;24:276–9.

    Article  CAS  Google Scholar 

  14. Cherqui D, Rahmouni A, Charlotte F, et al. Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. Hepatology. 1995;22(6):1674–81.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY, USA

    Rhonda K. Yantiss MD

Authors
  1. Rhonda K. Yantiss MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rhonda K. Yantiss MD .

Editor information

Editors and Affiliations

  1. Weill Medical College, Pathology and Laboratory Medicine, Cornell University, 525 East 68th St., New York, 10021, New York, USA

    Rhonda K. Yantiss

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Yantiss, R.K. (2011). Intraoperative Evaluation of Primary Hepatocellular Tumors. In: Yantiss, R. (eds) Frozen Section Library: Liver, Extrahepatic Biliary Tree and Gallbladder. Frozen Section Library. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0043-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-0043-1_1

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-0042-4

  • Online ISBN: 978-1-4614-0043-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation