Abstract
The molecular basis for hormone-receptor interactions is fundamentally important for understanding how extracellular hormones bind their receptors and trigger intracellular responses. Such information is crucial to the rational design of protein hormones optimized for affinity, receptor selectivity, and agonistic or antagonistic activities. Such modified hormones are powerful tools that can permit pharmacologists to link the action of specific cellular receptors with their physiological effect(s). Moreover, a detailed molecular analysis facilitates the rational design of improved hormone therapeutics as engineered proteins and possibly small molecule mimics.
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© 1994 Springer-Verlag New York, Inc.
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Wells, J., Cunningham, B., Fuh, G., Lowman, H., Ultsch, M., de Vos, B. (1994). Molecular Endocrinology of Human Growth Hormone. In: Bercu, B.B., Walker, R.F. (eds) Growth Hormone II. Serono Symposia USA Norwell, Massachusetts. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8372-7_17
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DOI: https://doi.org/10.1007/978-1-4613-8372-7_17
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