Skip to main content

Part of the book series: Industry and Health Care ((SSIND,volume 8))

  • 49 Accesses

Abstract

The issue concerning embryofetotoxic chemicals is not that the female employee is more susceptible than males to adverse health effects from workplace exposures. Rather, it arises from substances that can cross the placenta and, at concentrations that would have no adverse effect on any adult, cause damage to the developing embryo or fetus. The female is involved only because it is she who carries the unborn child. Determining the potential risk from exposure of the mother to a chemical is a scientific endeavor, while deciding the acceptability of an estimated risk is a societal and regulatory responsibility.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  • Karrh, Bruce W. Testimony before the National Advisory Committee on Occupational Safety and Health. Washington, D.C., May 1978.

    Google Scholar 

  • Done, A. K. “Perinatal Pharmacology.” Annual Review of Pharmacology 6 (1966): 189–208.

    Article  PubMed  CAS  Google Scholar 

  • Gibson, J. P., Staples, R. E., and Newberne, J. W, J. P., Staples, R. E., and Newberne, J. W. “Use of the Rabbit in Teratogenicity Studies.” Toxicology and Applied Pharmacology 9 (1966): 398–408.

    Article  CAS  Google Scholar 

  • Health and Welfare Agency of Canada. The Testing of Chemicals for Carcinogenicity, Mutagenicity and Teratogenicity. (1973): 135–183.

    Google Scholar 

  • Hurley, L. S. “Studies on Nutritional Factors in Mammalian Development.” Journal of Nutrition 91 (1967): 27–38.

    PubMed  CAS  Google Scholar 

  • Hurley, L. S. “Approaches to the Study of Nutrition in Mammalian Development.” Federation Proceedings 27 (1968): 193–198.

    PubMed  CAS  Google Scholar 

  • Jusko, W. J. “Pharmacodynamic Principles in Chemical Teratology: Dose-Effect Relationship.” Journal of Pharmacology and Experimental Therapeutics 184 (1972): 469–480.

    Google Scholar 

  • Kimmel, C. A., and Wilson, J. G. “Skeletal Deviations in Rats: Malformations or Variations?” Teratology 8 (1973): 309–316.

    Article  PubMed  CAS  Google Scholar 

  • Koll, W. “Some Considerations Concerning Testing for Teratogenic Action.” In Proceedings of European Society for the Study of Drug Toxicity, International Congress Series no. 73. (Amsterdam: 33 Apta Medical Foundation, 1963 ).

    Google Scholar 

  • von Kreybig, T., and von Kreybig-Hackenberger, I. “The Basic Principles of Testing Teratogenic Effects.” Arzneimittle—Forsch. 17 (1967): 390–392, (translation).

    Google Scholar 

  • Murphy, M. L. “Factors Influencing Teratogenic Response to Drugs.” Teratology: Principles and Techniques, ed J. G. Wilson and J. Warkany. ( Chicago: University of Chicago Press, 1965 ): 145–184.

    Google Scholar 

  • U.S. Department of Health, Education, and Welfare. “Reproduction, Teratology and Human Development.” In Human Health and the Environment: Some Research Needs. ( Washington, D.C.: DHEW, 1977 ): 315–328.

    Google Scholar 

  • U.S. Environmental Protection Agency. “Guidelines for Registering Pesticides in the United States.” Federal Register 40 (1975): 123.

    Google Scholar 

  • U.S. National Academy of Sciences. “Environmental Chemicals as Potential Hazards to Reproduction.” In Principles for Evaluating Chemicals in the Environment. (Washingtion, D.C.: USNAC, 1975 ): 156–197.

    Google Scholar 

  • U.S. National Research Council. Reproduction and Teratogenicity Tests, Part VII. Washington, D.C.

    Google Scholar 

  • Warkany, J. “Development of Experimental Mammalian Teratology.” In Teratology: Principles and Techniques, ed. J. G. Wilson and J. Warkany. ( Chicago: University of Chicago Press, 1965 ): 1–20.

    Google Scholar 

  • Warkany, J. “Trends in Teratologic Research: Epilogue to the Third International Congress on Congenital Malformations.” Teratology 3 (1970): 89–92.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, J. G. “Teratogenic Interaction of Chemical Agents in the Rat.” Journal of Pharmacology and Experimental Therapeutics 144: (1964): 429–436.

    CAS  Google Scholar 

  • Wilson, J. G. “Embryological Considerations in Teratology.” In Teratology: Principles and Techniques, ed. J. G. Wilson and U. Warkany. ( Chicago: Univ. of Chicago Press, 1965 ): 251–261.

    Google Scholar 

  • Wilson, J. G. “Methods for Administering Agents and Detecting Malformations in Experimental Animals.” In Teratology: Principles and Techniques ed. J. G. Wilson and J. Warkany. ( Chicago: University of Chicago Press, 1965 ): 262–277.

    Google Scholar 

  • Wilson, J. G. Environment and Birth Defects. ( New York: Academic Press, 1973 ).

    Google Scholar 

  • Wilson, J. G. “Present Status of Drugs as Teratogens in Man.” Teratology (1973): 3–15.

    Google Scholar 

  • Wilson, J. G. “Teratogenic Effects of Environmental Chemicals.” Federation Proceedings 36 (1973): 1698–1703.

    Google Scholar 

  • Wilson, J. G., and Warkany, J., Eds. Teratology: Principles and Techniques. ( Chicago: University of Chicago Press, 1965 ).

    Google Scholar 

  • World Health Organization. Technical Report Series, no. 364. Geneva, Switzerland, 1967.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Karrh, B.W. (1980). Evaluation and Control of Embryofetotoxic Substances. In: Walsh, D.C., Egdahl, R.H. (eds) Women, Work, and Health: Challenges to Corporate Policy. Industry and Health Care, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8077-1_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-8077-1_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-90478-8

  • Online ISBN: 978-1-4613-8077-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics