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Relationship between Procoagulant Activity and Metastatic Capacity of Tumor Cells

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Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

The involvement of blood coagulation in cancer cell growth and dissemination has been suggested on the basis of a variety of clinical and laboratory observations. Malignant disease is associated with a high incidence of vascular thrombosis, as recognized by Trousseau more than a century ago (1), and this has been repeatedly demonstrated in many clinical studies by other investigators (2–6). Disseminated intravascular coagulation (DIC), probably the most complex and severe acquired coagulopathy, frequently occurs in patients bearing solid, metastatic tumors and several types of leukemias (4, 7). Moreover, malignancy is one of the main risk factors which potentiate the incidence of thrombosis during post-operative or post-trauma periods (7). Clinical laboratory findings have demonstrated a number of hemostatic abnormalities indicating an overt or low grade activation of the clotting system in malignant disease, even in the absence of hemorrhagic or thrombotic signs (8–13).

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Authors
  1. Maria Benedetta Donati
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  2. Nicola Semeraro
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  3. Stuart G. Gordon
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

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© 1984 Martinus Nijhoff Publishing, Boston

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Donati, M.B., Semeraro, N., Gordon, S.G. (1984). Relationship between Procoagulant Activity and Metastatic Capacity of Tumor Cells. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_7

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

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