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PCDDs and Related Compounds: Metabolism and Biochemistry

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Human and Environmental Risks of Chlorinated Dioxins and Related Compounds

Part of the book series: Environmental Science Research ((ESRH,volume 26))

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Abstract

Polychlorinated dibenzo-p-dioxins and related halogenated aromatic compounds are a group of chemicals which exhibit similar physical and environmental properties and elicit a number of common toxic and biologic responses. Moreover within each group of halogenated aromatics, there area multiplicity of isomers and congeners and their metabolism and biochemical effects are remarkable dependent on structure. The metabolism of individual halogenated aromatics thus depends on their degree of halogenation and the specific halogen substitution pattern. Complementary results obtained for the poly-chlorinated dibenzo-p-dioxins and biphenyls show that the toxic congeners are approximate isostereomers of 2,3,7,8-tetrachlorodibenzo- p-dioxin; furthermore, there exists a correlation between the toxicity of halogenated aromatics and their binding activities to a cytosolic receptor protein and potencies as inducers of microsomal aryl hydrocarbon hydroxylase.

Guelph-Waterloo Centre for Graduate Work in Chemistry,University of Guelph,Guelph,Ontario,Canada

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Authors and Affiliations

  1. College of Veterinary Medicine, Texas A&M University, College Station, Texas, USA

    S. Safe, L. Robertson, T. Sawyer, S. Bandiera & L. Safe

  2. Hoffman laRoche Corporation Nutley, Nutley, New Jersey, USA

    A. Parkinson & M. Campbell

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  1. S. Safe
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  2. L. Robertson
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  4. A. Parkinson
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  5. S. Bandiera
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  6. L. Safe
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Editors and Affiliations

  1. Dynamac Corp Enviro Control Division, Rockville, Maryland, USA

    Richard E. Tucker  & Allan P. Gray  & 

  2. U.S. Veterans Administration, Washington, D.C., USA

    Alvin L. Young

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© 1983 Plenum Press, New York

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Safe, S. et al. (1983). PCDDs and Related Compounds: Metabolism and Biochemistry. In: Tucker, R.E., Young, A.L., Gray, A.P. (eds) Human and Environmental Risks of Chlorinated Dioxins and Related Compounds. Environmental Science Research, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3599-3_26

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  • DOI: https://doi.org/10.1007/978-1-4613-3599-3_26

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4613-3599-3

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