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Minamata Disease

Organic Mercury Poisoning Caused by Ingestion of Contaminated Fish

  • Chapter
Adverse Effects of Foods

Abstract

Minamata disease is unique in its mechanism of outbreak. Organic mercury discharged with the wastewater from an industrial plant polluted the environment, which in turn contaminated fish and shellfish. People who ingested these marine products then became poisoned. Such widespread methyl mercury (MeHg) poisoning was the first occurrence in the history of mankind. The incident was instructive in the following sense. The seas, rivers, and atmosphere had long been regarded as places where people could throw away and dump wastes without a second thought. However, it was demonstrated that a certain substance in the environment would accumulate through the food chain and finally cause people to suffer from its toxicity. Not only persons who ingested the contaminated food were affected; embryos in the uterus suffered even more severe damages. It also became apparent that once the environment was polluted, restoring it to an acceptable state was almost impossible.

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References

  • Åberg, B., Ekman, L., Falk, R., Greitz, U., Persson, G., and Snihs, J. O., 1969, Metabolism of methyl mercury (203Hg) compounds in man, Arch. Environ. Health 19: 478.

    Google Scholar 

  • Bakir, F., Damluji, S. F., Amin-Zaki, L., Murtadha, M., Khalidi, A., Al-Rawi, N. Y., Tiriti, S., Dhakir, H. I., Clarkson, T. W., Smith, J. C., and Doherty, R. A., 1973, Methyl mercury poisoning in Iraq, Science 181: 230.

    Article  CAS  Google Scholar 

  • Deshimaru, M., 1969, Electron microscopic studies on experimental organic mercury poisoning in nursling rat brain (Jpn. ed.), Psychiatr. Neurol. Jap. 71:506.

    CAS  Google Scholar 

  • Friberg, L. (ed.), 1971, Methyl mercury in fish, Nord. Hyg. Tidskr. Suppl. 4, Stockholm, Sweden.

    Google Scholar 

  • Fujiki, M ., 1972, The transitional condition of Minamata Bay and the neighbouring sea polluted by factory wastewater containing mercury, Reprinted at the 6th International Water Pollution Research, June 18–23.

    Google Scholar 

  • Funatsu, I., and Yamashita, F., 1972, Polychlorbiphenyls (PCB) induced fetopathy, I. Clinical observation, Kurume Med. J. 19: 43.

    Article  CAS  Google Scholar 

  • Futatsuka, S., Ueda, A., Teruya, H., Ueda, T., Nomura, S., and Hirano, T., 1974, Eating habits and labor of fishermen’s families in Shiranui area, Jm. J. Pub. Health 21: 825.

    Google Scholar 

  • Fuyuta, M., Fujimoto, T., and Hirata, S., 1978, Embryotoxic effects of methylmercuric chloride administered to mice and rats during organogenesis, Teratology 18: 353.

    Article  CAS  Google Scholar 

  • Harada, M., 1964, Neuropsychiatric disturbances due to organic mercury poisoning during the prenatal period (Jpn. ed.), Psychiat. Neurol. Jpn. 66:426.

    Google Scholar 

  • Harada, M., 1972a, Minamata Byo (Jpn. ed.), Iwanami-Shoten, Tokyo.

    Google Scholar 

  • Harada, M., 1972b, Clinical studies on prolonged Minamata disease (Jpn. ed.), Psychiat. Neurol. Jpn. 74:668.

    Google Scholar 

  • Harada, M., 1975, Minamata Disease, words and photographs by E. Smith and A. M. Smith, p. 51, Holt, Reinhardt and Winston, New York.

    Google Scholar 

  • Harada, M., 1976, Intrauterine poisoning: Clinical and epidemiological studies and significance of the problem, Bull. Inst. Constit. Med. Kumamoto Univ. Suppl. 25: 1.

    Google Scholar 

  • Harada, M., 1977, Congenital Minamata disease. Intrauterine methyl mercury poisoning, Teratology 18: 285.

    Article  Google Scholar 

  • Harada, M., 1978a, Methyl mercury poisoning due to environmental contamination “Minamata disease,” in: Toxicity of Heavy Metals in the Environment, Part 1 (F. W. Oehme, ed.), p. 261, Marcel Dekker, New York and Basel.

    Google Scholar 

  • Harada, M., 1978b, Minamata disease as a social and medical problem, Jpn. Q. 25: 20.

    Google Scholar 

  • Iesato, K., Wakashi, M., Wakashi, Y., and Togo, S., 1977, Renal tubular dysfunction in Minamata disease, Ann. Intern. Med. 86: 731.

    CAS  Google Scholar 

  • Kitamura, S., Hirano, Y., Noguchi, Y., Kojima, T., Kakita, T., and Kuwaki, H., 1959, The epidemiological survey on Minamata disease (No. 2) (Jpn. ed.), J. Kumamoto Med. Soc. 33(Suppl. 3):569.

    Google Scholar 

  • Kitamura, S., Kakita, T., Kojoo, J., and Kojima, T., 1960a, A supplement to the results of the epidemiological survey on Minamata disease (No. 3) (Jpn. ed.), J. Kumamoto Med. Soc. 34(Suppl. 3):476.

    Google Scholar 

  • Kitamura, S., Ueda, K., et al., 1960b, Chemical examination of Minamata disease (No. 5) (Jpn. ed.), J. Kumamoto Med. Soc. 34(Suppl. 3):593.

    Google Scholar 

  • Kitamura, S., 1974, Accumulation of mercury in human body, (Jpn. ed.), Adv. Neurol. Sci. 18:825.

    CAS  Google Scholar 

  • Löfroth, G., 1969, Toxicity of mercury compounds in the environment, Kagaku (Science) 39:592. ( Jpn. ed., translated by J. Ui )

    Google Scholar 

  • Matsumoto, H., Koya, G., and Takeuchi, T., 1965, Fetal Minamata disease. A neuropathological study of two cases of intrauterine intoxication by methyl mercury compound, J. Neuropathol. Exp. Neurol. 24: 563.

    Article  CAS  Google Scholar 

  • McAlpine, D., and Araki, S., 1958, Minamata disease. An unusual neurological disorder caused by contaminated fish, Lancet 20 (Sept.): 629.

    Article  Google Scholar 

  • Nishigaki, S. M., and Harada, M., 1975, Methyl mercury and selenium in umbilical cords of inhabitants of the Minamata area, Nature 258: 324.

    Article  CAS  Google Scholar 

  • Rustam, H., and Hamdi, T., 1974, Methyl mercury poisoning in Iraq. A neurological study, Brain 97:499.Study Group of Minamata Disease, 1968, Minamata Disease, Kumamoto University, Kumamoto City, Japan.

    Google Scholar 

  • Sera, K., Sato, A., et al., 1957, An experimental study on unknown disease of Minamata area (Jpn. ed.), J. Kumamoto Med. Soc. 31(Suppl. 2):307.

    Google Scholar 

  • Shiraki, H. and Takeuchi, T., 1971, Minamata disease, in: Pathology of the Nervous System (II) ( J. Minckler, ed.) McGraw-Hill, Inc., New York.

    Google Scholar 

  • Study Group of Minamata Disease, 1968, Minamata Disease, Kumamoto University, Kumamoto City, Japan.

    Google Scholar 

  • Tokuomi, H., 1960, Clinical observation and pathogenesis of Minamata disease (Jpn. ed.) Psychiat. et Neurol. Jap. 62:1816.

    Google Scholar 

  • Tsubaki, T., 1968, Organic mercury poisoning in Agano area, (Jpn. ed.) Clin. Neurol. 8:511.

    Google Scholar 

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© 1982 Plenum Press, New York

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Harada, M. (1982). Minamata Disease. In: Jelliffe, E.F.P., Jelliffe, D.B. (eds) Adverse Effects of Foods. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3359-3_13

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  • DOI: https://doi.org/10.1007/978-1-4613-3359-3_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3361-6

  • Online ISBN: 978-1-4613-3359-3

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