Abstract
Currently a controversy exists regarding the roles of bone marrow transplantation and chemotherapy in the treatment of acute nonlymphocytic leukemia (ANLL). While each therapeutic approach has dedicated proponents, it is clear that these therapeutic modalities should not be considered as competitors but rather as alternate and complimentary therapies. This paper will attempt to review each approach impartially, and then propose an approach to the treatment of patients with ANLL. The discussion will be limited to patients who enter complete remission at the time of initial diagnosis.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Rai KR, Glidewell O, Holland JF et al: Treatment of acute myelocytic leukemia: A study by cancer and leukemia group B. Blood 58: 1203–1212, 1981.
Rees JKL, Sandler RM, Challener J et al: Treatment of acute myeloid leukemia with a triple cytotoxic regimen (DAT). British Journal of Cancer 36: 770–776, 1977.
Preisler HD, Bjornsson S, Henderson ES et al: Treatment of acute nonlymphocytic leukemia: Use of anthracycline–cytosine arabinoside induction therapy and a comparison of two maintenence regimens. Blood 53: 455–464, 1979.
Keating MJ: Factors influencing disease free interval after achieving complete remission in acute leukemia. In: Minimal Residual Disease in Acute Leukemia. Lowenberg B, Hagenbeek A (eds) Martinus Nijhoff, Boston, The Hague, Dordrecht, Lancaster, 1984, pp. 149–164.
Preisler H, Anderson K, Rai K et al: Comparison of survival of patients with acute nonlymphocytic leukemia receiving maintenance chemotherapy or marrow transplantation in 1st remission. Abstracts of ASCO 5/22–5/24, 1983.
Weinstein JD, Mayer RJ, Rosenthal DS et al: Treatment of acute myelogenous leukemia in children and adults. New Eng. J. Medicine 303: 473–478, 1981.
Preisler HD, Brecher M, Browman G et al: The treatment of acute myelocytic leukemia in patients 30 years of age and younger. Am. J. Hem. 13: 189–198, 1982.
Thomas, ED, Buckner CD, Clift RA et al: Marrow transplantation for acute nonlymphoblastic leukemia in first remission. New Eng. J. Med. 301: 597–599, 1979.
Powles RL, Morgenstern G, Clink HM et al: The place of bone marrow transplantation in acute myelogenous leukemia. Lancet 1: 1047–1050, 1980.
Forman SJ, Blume KG: Bone marrow transplantation for leukemia. In: Hematology l: Leukemias. Goldman JM, Preisler HG (eds) Butterworths, London, Boston, 1984, pp. 322–329.
Thomas ED, Clift RA, Buckner CD: Marrow transplantation for patients with acute nonlymphoblastic leukemia who achieve a first remission. Cancer Treat. Rep. 66: 1463 1466, 1982.
Applebaum F: Personal communication, 1984.
Preisler HD: Bone marrow transplantation for adults over 30 years of age with acute nonlymphocytic leukemia. In: Current Drugs and Methods of Cancer Treatment. Chap 24, pp. 127–128, 1983.
Preisler HD: Therapy for patients with acute myelocytic leukemia who enter remission: Bone marrow transplantation or chemotherapy? Cancer Treat. Rep. 66: 1467–1473, 1982.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Preisler, H.D. (1985). Treatment Choices for Patients with Acute Nonlymphocytic Leukemia in Remission: Chemotherapy and Bone Marrow Transplantation. In: Baker, L., Valeriote, F., Ratanatharathorn, V. (eds) Biology and Therapy of Acute Leukemia. Developments in Oncology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2609-0_13
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2609-0_13
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9633-1
Online ISBN: 978-1-4613-2609-0
eBook Packages: Springer Book Archive