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Toxicological Studies in Insects

  • Chapter
Toxicology of Insecticides

Abstract

The body surface of insects consists of a hard skin known as the cuticle. At first glance it appears that this barrier should be very effective against the entry of insecticides, but there are two main reasons why it is not: (1) the insect exposes a far greater surface area relative to its volume than the mammal, and (2) the insect cuticle is hydrophobic (i.e., lipophilic) so that it can resist desiccation and drowning. Most modern insecticides are apolar and therefore easily penetrate the insect cuticle. Mammalian skin, by contrast, is relatively resistant to the entry of insecticides. As a result, it is common that the acute oral toxicity of an insecticide is much higher in mammals than the contact toxicity, where as the contact and oral toxicities are almost equal in insects. Though in insects cuticular penetration is usually the major pathway, in some instances insecticides do enter by way of the mouth, respiratory system, and other vulnerable places such as the antennae, eyes, and tarsi.

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References

  • Abedi, Z. H., and A. W. A. Brown (1961). Ann. Entomol. Soc. Am. 54: 539.

    CAS  Google Scholar 

  • Ahmed, H., and B. G. Gardiner (1967). Nature 214: 1338.

    PubMed  CAS  Google Scholar 

  • Ahmed, H., and B. G. Gardiner (1968). Bull Entomol Res. 57: 651.

    PubMed  CAS  Google Scholar 

  • Alexandrov, W. J. (1935). Acta Zool 16: 1.

    Google Scholar 

  • Armstrong, G., F. Bradburg, and H. Standen (1951). Ann. Appl Biol 38: 555.

    CAS  Google Scholar 

  • Beament, J. W. L. (1945). J. Exp. Biol 21: 115.

    Google Scholar 

  • Benezet, H. J., and A. J. Forgash (1972a). J. Econ. Entomol. 65: 53.

    PubMed  CAS  Google Scholar 

  • Benezet, H. J., and A. J. Forgash (19726). J. Econ. Entomol. 65: 895.

    Google Scholar 

  • Blum, M. S., and C. W. Kearns (1956). J. Econ. Entomol. 49: 862.

    CAS  Google Scholar 

  • Brown, A. W. A. (1958). Insecticide Resistance in Arthropods. World Health Organization, Geneva.

    Google Scholar 

  • Brown, A. W. A. (1960). Annu. Rev. Entomol. 5: 301.

    CAS  Google Scholar 

  • Brown, A. W. A. (1971). In Pesticides in the Environment. R. White-Stevens, ed. Marcel Dekker, New York, Vol. 1, pp. 457–552.

    Google Scholar 

  • Brown, A. W. A., and R. Pal (1971). Insecticide Resistance in Arthropods. WHO Monograph Series 38, Geneva.

    Google Scholar 

  • Brown, T. M., and A. W. A. Brown (1974). J. Econ. Entomol. 67: 799.

    PubMed  CAS  Google Scholar 

  • Casida, J. E. (1969). In Microsomes and Drug Oxidations. J. R. Gillette, A. H. Conney, G. J. Cosmides, R. W. Estabrook, J. R. Fouts, and G. J. Mannering, eds. Academic Press, New York, pp. 517–530.

    Google Scholar 

  • Casida, J. E. (1970). J. Agr. Food Chem. 18 (5): 753–772.

    CAS  Google Scholar 

  • Chathoraj, A. N., and A. W. A. Brown (1960). J. Econ. Entomol. 53: 1049.

    Google Scholar 

  • Collins, W. J., and A. J. Forgash (1970). J. Econ. Entomol. 63: 394.

    PubMed  CAS  Google Scholar 

  • Croft, B. A. (1977). In Pesticide Management and Insecticide Resistance. D. L. Watson and A. W. A. Brown, eds. Academic Press, New York, p. 638.

    Google Scholar 

  • Croft, B. A., and S. C. Hoyt (1978). Environ. Entomol. 7: 627.

    Google Scholar 

  • Croft, B. A., and K. Strickler (1983). In Pest Resistance to Pesticides. G. P. Georghiou and T. Saito, eds. Plenum Press, New York, p. 669.

    Google Scholar 

  • Crow, J. F. (1957). Annu. Rev. Entomol. 2: 227.

    CAS  Google Scholar 

  • Davison, H., and J. F. Danielli (1952). The Permeability of Natural Membranes. Cambridge University Press, Cambridge.

    Google Scholar 

  • DeVries, D. H., and G. P. Georghiou (1981). Pestic. Biochem. Physiol. 15: 242.

    CAS  Google Scholar 

  • Dierick, G. F. E. M. (1943). Tijdschr. Plantenziekt. 49: 22.

    CAS  Google Scholar 

  • Dorough, H. W., and J. E. Casida (1964). J. Agr. Food Chem. 12: 294.

    CAS  Google Scholar 

  • Dyte, C. E., and D. G. Rowlands (1968). J. Stored Prod. Res. 4: 157.

    CAS  Google Scholar 

  • El Bashir, S., and F. J. Oppenoorth (1969). Nature 223: 210.

    PubMed  Google Scholar 

  • Eldefrawi, M. E., R. Miskus, and V. Sutcher (1960). J. Econ. Entomol. 53: 231.

    CAS  Google Scholar 

  • Ellisor, L. O. (1936). Iowa State Coll. J. Sci. 11:51. Feroz, M. (1971). Bull World Health Org. 45: 795.

    Google Scholar 

  • Fisher, R. W. (1952). Can. J. Zool 30: 254.

    Google Scholar 

  • Forgash, A. J., B. J. Cook, and R. C. Riley (1962). J. Econ. Entomol 55: 544.

    CAS  Google Scholar 

  • Fukami, J., and T. Shishido (1963). Botyu-Kagaku ISill. Fukami, J., and T. Shishido (1966). J. Econ. Entomol 59: 1338.

    Google Scholar 

  • Georghiou, G. P. (1971). In Proceedings of the 2nd International IUPAC Congress of Pesticide Chemistry. A. S. Tahori, ed. Gordon and Breach, New York, Vol. II, pp. 77 - 94.

    Google Scholar 

  • Georghiou, G. P. (1972). Annu. Rev. Ecol Syst. 3: 133.

    CAS  Google Scholar 

  • Georghiou, G. P. (1983). In Pest Resistance to Pesticides. G. P. Georghiou and T. Saito eds., Plenum Press, New York, p. 769.

    Google Scholar 

  • Georghiou, G. P., and R. L. Metcalf (1961). J. Econ. Entomol 54: 231.

    CAS  Google Scholar 

  • Georghiou, G. P. and N. Pasteur (1980). J. Econ. Entomol 73 (4): 489.

    CAS  Google Scholar 

  • Gerolt, P. (1969). J. Insect Physiol 15: 563.

    PubMed  CAS  Google Scholar 

  • Ghiasuddin, S. M., and F. Matsumura (1982). Comp. Biochem. Physiol 73C: 141.

    Google Scholar 

  • Ghiasuddin, S. M., A. A. Kadous, and F. Matsumura (1981). Comp. Biochem. Physiol C 68: 15.

    Google Scholar 

  • Gil, L., B. C. Fine, M. L. Dinamarca, I. Balazs, J. R. Busvine, and M. Agosin (1968). Entomol Exp. Appl. 11: 15.

    CAS  Google Scholar 

  • Hayashi, M., and F. Matsumura (1967). J. Agr. Food Chem. 15: 622.

    CAS  Google Scholar 

  • Hayes, W. P., and Y.-S. Liu (1947). Ann. Entomol Soc. Am. 40:401. Hurst, H. (1943). Trans. Faraday Soc. 39:390; Nature 152: 292.

    Google Scholar 

  • Iljinskaya, M. I. (1946). Compt. Rend. Acad. Sci. USSR 51:557. Iwata, T., and H. Hama (1972). J. Econ. Entomol. 65: 643.

    Google Scholar 

  • Kadous, A. A., S. M. Ghiasuddin, J. G. Scott, and F. Matsumura (1983). Pestic. Biochem. Physiol 19: 157.

    CAS  Google Scholar 

  • Kikkawa, H. (1964). Boty-Kagaku 29 (3): 37.

    Google Scholar 

  • Klinger, H. (1936). Arb. Physiol. Angew. Entomol. 3: 49, 115.

    Google Scholar 

  • Kojima, K., T. Ishizuka, and S. Kitakata (1963). Botyu-Kagaku 28: 17.

    CAS  Google Scholar 

  • Krueger, H. R., and R. D. O’Brien (1959). J. Econ. Entolmol. 52: 1063.

    CAS  Google Scholar 

  • Lagunes, A. T. (1980). Impact of the Use of Mixtures and Sequences of Tissues in the Evolution of Resistance in Culex quinquefaciatus. Ph.D. dissertation, University of California, Riverside.

    Google Scholar 

  • Leeling, N. N., and J. E. Casida (1966). J. Agr. Food Chem. 14: 281.

    CAS  Google Scholar 

  • Lees, A. D. (1946). Parasitology 37: 1.

    PubMed  CAS  Google Scholar 

  • Lees, A. D. (1947). J. Exp. Biol. 23: 291.

    Google Scholar 

  • Lewis, C. T. (1965). J. Insect Physiol. 11: 683.

    PubMed  CAS  Google Scholar 

  • Lewis, J. B. (1969). Nature 224: 917.

    PubMed  CAS  Google Scholar 

  • Lewis, J. B., and R. M. Sawicki (1971). Pestic. Biochem. Physiol. 1:275. Lindquist, D. A., and P. A. Dahm (1956). J. Econ. Entomol. 49: 579.

    Google Scholar 

  • Matsumura, F. (1959). The Permeability of Insect Cuticle. M.S. thesis, University of Alberta, Edmonton, Canada.

    Google Scholar 

  • Matsumura, F. (1963). J. Insect Physiol 9: 207.

    Google Scholar 

  • Matsumura, F., and A. W. A. Brown (1961). J. Econ. Entomol 54: 1176.

    Google Scholar 

  • Matsumura, F., and A. W. A. Brown (1963). J. Econ. Entomol 56: 381.

    CAS  Google Scholar 

  • Matsumura, F., and M. Hayashi (1966). Science 153: 757.

    PubMed  CAS  Google Scholar 

  • Matsumura, F., and M. Hayashi (1967). J. Agr. Food Chem. 15: 622.

    Google Scholar 

  • Matsumura, F., and M. Hayashi (1969). Residue Rev. 25: 265.

    PubMed  CAS  Google Scholar 

  • Matsumura, F., and C. J. Hogendijk (1964a). Entomol Exp. Appl 7: 179.

    CAS  Google Scholar 

  • Matsumura, F., and C. J. Hogendijk (19646). J. Agr. Food Chem. 12: 447.

    Google Scholar 

  • Matsumura, F., and K. Tanaka (1984). In Cellular and Molecular Basis of Neurotoxicity of Environmental Agents. T. Narahashi, ed. Raven Press, New York.

    Google Scholar 

  • Matsumura, F., and G. Voss (1964). J. Econ. Entomol 57: 911.

    CAS  Google Scholar 

  • Matsumura, F., and G. Voss (1965). J. Insect Physiol. 11: 147.

    PubMed  CAS  Google Scholar 

  • Metcalf, R. L. (1980) Annu. Rev. Entomol 25: 219.

    CAS  Google Scholar 

  • Milani, R. and A. Travaglino (1957). Riv. Parasitol. 188: 199.

    Google Scholar 

  • Miller, T. A., M. Maynard, and J. M. Kennedy (1979). Pestic. Biochem. Physiol 10: 128.

    CAS  Google Scholar 

  • Motoyama, N., and W. C. Dauterman (1972). Pestic. Biochem. Physiol 2: 113.

    CAS  Google Scholar 

  • Motoyama, N., G. C. Rock, and W. C. Dauterman (1971). Pestic. Biochem. Physiol 1: 205.

    CAS  Google Scholar 

  • Mullin, C. A., B. A. Croft, K. Strickler, F. Matsumura, and J. R. Miller (1982). Science 217: 1270.

    PubMed  CAS  Google Scholar 

  • Nakatsugawa, T., N. M. Tolman, and P. A. Dahm (1969). J. Econ. Entomol 62: 408.

    PubMed  CAS  Google Scholar 

  • O’Brien, R. D. (1967). Insecticides: Action and Metabolism. Academic Press, New York.

    Google Scholar 

  • O’Brien, R. D., and R. W. Fisher (1958). J. Econ. Entomol 51: 169.

    Google Scholar 

  • O’Kane, W. C., G. L. Walker, H. G. Guy, and O. J. Smith (1933). Tech. Bull New Hampshire Agr. Exp. Station 54: 1.

    Google Scholar 

  • O’Kane, W. C., L. C. Glover, R. L. Blickle, and B. M. Parker (1940). Tech. Bull New Hampshire Agr. Exp. Station 74: 1.

    Google Scholar 

  • Olson, W. D., and R. D. O’Brien (1963). J. Insect Physiol 9: 777.

    CAS  Google Scholar 

  • Oppenoorth, F. J. (1965). Meded. Landbouwhoge school Opzoekingsstat. Gent. 30: 1390.

    CAS  Google Scholar 

  • Oppenoorth, F. J. (1972). In Toxicology, Biodegradation and Efficacy of Livestock Pesticides. M. A. Q. Khan and W. O. Haufe, eds. Swets and Zeitlinger, Amsterdam, pp. 73–92.

    Google Scholar 

  • Oppenoorth, F. J., and W. Welling. (1976). In Insecticide Biochemistry and Physiology. C. F. Wilkinson, ed. Plenum Press, New York, pp. 507 - 554.

    Google Scholar 

  • Oppenoorth, F. J., and K. van Aspersen (1961). Entomol. Exp. Appl. 4: 311.

    CAS  Google Scholar 

  • Oppenoorth, F. J., S. Voerman, W. Welling, N. W. H. Houx, and J. Wouters van den Oudenweyer (1971). Nature New Biol. 233: 187.

    PubMed  CAS  Google Scholar 

  • Oppenoorth, F. J., V. Rupes, S. El Bashir, N. W. H. Houx, and S. Voerman (1972). Pestic. Biochem. Physiol. 2 (3): 262.

    CAS  Google Scholar 

  • Pal, R. (1951). Bull. Entomol. Res. 51: 121.

    Google Scholar 

  • Perry, A. S., and W. M. Hoskins (1950). Science 111: 600.

    PubMed  CAS  Google Scholar 

  • Plapp, F. W., Jr. (1979). Genetic origin of insecticide resistance. Pest resistance to pesticides: Challenges and prospects. U.S.-Japan seminar, Palm Springs, December 3 - 7, 1979.

    Google Scholar 

  • Plapp, F. W., Jr. (1981). Paper presented at the Annual Meeting of the Entomological Society of America, San Diego, December 1981.

    Google Scholar 

  • Plapp, F. W., Jr., and R. F. Hoyer (1968). J. Econ. Entomol. 61: 761.

    CAS  Google Scholar 

  • Quraishi, M. S., and Z. T. Poonawalla (1969). J. Econ. Entomol. 62: 988.

    PubMed  CAS  Google Scholar 

  • Richards, A. G., and L. K. Cutkomp (1946). Biol. Bull. 90: 97.

    PubMed  CAS  Google Scholar 

  • Richards, A. G., and F. M. Korda (1948). Ann. Entomol. Soc. Am. 43: 49.

    Google Scholar 

  • Roy, D. N., S. M. Ghosh, and R. N. Chopra (1943). Ann. Appl. Biol. 30: 42.

    CAS  Google Scholar 

  • Sarkaria, D. S., and R. L. Datton (1949). Trans. Entomol. Soc. Am. 175: 71.

    Google Scholar 

  • Sawicki, R. M. (1973). Pestic. Sci. 4: 501.

    CAS  Google Scholar 

  • Sawicki, R. M., and A. W. Farnham (1967). Entomol. Exp. Appl. 10: 253.

    CAS  Google Scholar 

  • Scott, J. G., and F. Matsumura (1981). Pestic. Biochem. Physiol. 16 (1): 21.

    CAS  Google Scholar 

  • Shrivastava, S. P., M. Tsukamoto, and J. E. Casida (1969). J. Econ. Entomol. 62: 483.

    CAS  Google Scholar 

  • Shrivastava, S. P., G. P. Georghiou, R. L. Metcalf, and T. R. Fukuto (1970). Bull World Health Org. 42: 931.

    PubMed  CAS  Google Scholar 

  • Smissaert, H. R. (1964). Science 143: 129.

    PubMed  CAS  Google Scholar 

  • Sternburg, J., C. W. Kearns, and W. N. Bruce (1950). J. Econ. Entomol. 43: 214.

    CAS  Google Scholar 

  • Sternburg, J., C. W. Kearns, and H. H. Moorefield (1954). Agr. Food Chem. 2: 1125.

    CAS  Google Scholar 

  • Stone, B. F., J. T. Wilson, and N. J. Youlton (1973). Aust. J. Biol. Sci. 26 (2): 445.

    PubMed  CAS  Google Scholar 

  • Tattersfield, F., C. Potter, and E. M. Gillhem (1947). Bull. Entomol. Res. 37: 497.

    PubMed  CAS  Google Scholar 

  • Telford, J. N., and F. Matsumura (1970). J. Econ. Entomol. 63: 795.

    PubMed  CAS  Google Scholar 

  • Telford, J. N., and F. Matsumura (1971). J. Econ. Entomol. 64: 230.

    CAS  Google Scholar 

  • Townsend, M. G., and J. R. Busvine (1969). Entomol. Exp. Appl. 12: 243.

    CAS  Google Scholar 

  • Treherne, J. E. (1957). J. Insect Physiol. 1: 178.

    CAS  Google Scholar 

  • Tripathi, R. K., and R. D. O’Brien (1973). Pestic. Biochem. Physiol. 3: 495.

    CAS  Google Scholar 

  • Tsukamoto, M. (1961). Botyu-Kagaku 26: 74.

    Google Scholar 

  • Tsukamoto, M., and J. E. Casida (1967a). Nature 213: 49.

    CAS  Google Scholar 

  • Tsukamoto, M., and J. E. Casida (19676). J. Econ. Entomol. 60: 617.

    Google Scholar 

  • Tsukamoto, M., T. Narahashi, and T. Yamasaki (1965). Botyu-Kagaku 30: 128.

    Google Scholar 

  • Tsukamoto, M., S. P. Shrivastava, and J. E. Casida (1968). J. Econ. Entomol. 61: 50.

    PubMed  CAS  Google Scholar 

  • Van den Bercken, J., L. M. A. Akkermans, and J. M. van der Zalm (1973). Eur. J. Pharmacol. 21: 95.

    PubMed  Google Scholar 

  • Vinson, S. B., and F. W. Plapp (1974). J. Agr. Food Chem. 2: 356.

    Google Scholar 

  • Webb, J. E., and R. A. Green (1946). J. Exp. Biol. 22: 8.

    Google Scholar 

  • Welling, W., P. T. Blaakmeer, G. J. Vink, and S. Voerman (1971). Pestic. Biochem. Physiol. 1:61. Wharton, R. H., W. J. Roulston, J. William, K. B. W. Utech, and J. D. Kerr (1970). Aust. J. Agr. Res. 21 (6): 985.

    Google Scholar 

  • Wigglesworth, V. B. (1942). Bull Entomol Res. 33: 205.

    CAS  Google Scholar 

  • Wigglesworth, V. B. (1945). J. Exp. Biol. 21: 9.

    Google Scholar 

  • Wilkinson, C. F. (1971). Bull. World Health Org. 44: 171.

    PubMed  CAS  Google Scholar 

  • Yamamoto, I., Y. Takahashi, and N. Kyomura (1983). In Pest Resistance to Pesticides. G. P. Georghiou and T. Saito, eds. Plenum Press, New York, pp. 579–594.

    Google Scholar 

  • Yamasaki, T., and T. Narahashi (1958). Botyu-Kagaku 23: 47.

    Google Scholar 

  • Yang, R. S. H., E. Hodgson, and W. C. Dauterman (1971). J. Agr. Food Chem. 19: 14.

    CAS  Google Scholar 

  • Yu, S. J., and L. C. Terriere (1973). Pestic. Biochem. Physiol. 3: 259.

    Google Scholar 

Download references

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    Fumio Matsumura

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Matsumura, F. (1985). Toxicological Studies in Insects. In: Toxicology of Insecticides. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2491-1_6

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