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Clinical Heterogeneity in Patients with Dementia of the Alzheimer Type

  • Chapter
Alzheimer’s and Parkinson’s Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 29))

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Abstract

Clinical criteria for the diagnosis of dementia of the Alzheimer type (DAT) vary considerably in the current literature (1–4). Most investigators develop uniform criteria in order to be certain of homogeneity within a given cohort of patients for research purposes. Restricted criteria can lead to refinement in diagnosis, particularly when supported by careful postmortem verification (4–6). In view of this, several investigations are currently in progress to develop both qualitative and quantitative clinical and diagnostic measures for use in DAT.

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References

  1. Eisendorfer C, Cohen D: Diagnostic criteria for primary neuronal degeneration of the Alzheimer type. J Fam Pract 1980; 2: 553–7.

    Google Scholar 

  2. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RD: A new clinical scale for the staging of dementia. Brit J Psychiat 1982; 140: 566–72.

    Article  PubMed  CAS  Google Scholar 

  3. Berg L, Hughes CP, Coben LA, Danziger WL, Martin RL, Knesevich J: Mild senile dementia of the Alzheimer type: Research diagnostic criteria,recruitment and description of a study population. J Neurol Neurosurg Psychiat 1982; 45: 962–8.

    Article  PubMed  CAS  Google Scholar 

  4. Todorov AB, Go RCP, Constantinidis J, Elston RC: Specificity of the clinical diagnosis of dementia. J Neurol Sci 1975; 26: 81–98.

    Article  PubMed  CAS  Google Scholar 

  5. Ron MA, Toone BK, Graralda ME, Lishroan WA: Diagnostic Accuracy in presenile dementia. Brit J Psychiat 1979: 161–8.

    Google Scholar 

  6. Sulka R, Matti H, Paetan A, Wikstom J, Palo J: Accuracy of clinical diagnosis in primary degenerative donentia: Correlation with neuropathological findings. J Neurol Neurosurg Psychiat 1983; 46: 9–13.

    Article  Google Scholar 

  7. Crystal HA, Horoupian DS, Katzman R, Jotkowitz S: Biopsy-proven Alzheimer disease presenting as a right parietal lobe syndrome. Ann Neurol 1982; 12: 186–8.

    Article  PubMed  CAS  Google Scholar 

  8. Bird TD, stranahan S, Sumi M, Raskind M: Alzheimer’s disease and choline acetyltransferase activity in brain tissue from clinical and pathological subgroups. Ann Neurol 1983; 14: 284–93.

    Article  PubMed  CAS  Google Scholar 

  9. Jacob H: Muscular twitching in Alzheimer’s disease. In: Wolstenholme GEW, O’Conner M, eds. Alzheimer’s disease and related ccnditions. London: Churchill. 1970: 75–93.

    Google Scholar 

  10. Faden AL, Townsoid JJ: myoclonus in Alzheimer’s disease. Arch Neurol 1976; 33: 278–80.

    PubMed  CAS  Google Scholar 

  11. Mayeux R, Hunter S, Fahn S: More on myoclonus in Alzheimer’s disease. Ann Neurol 1980; 8: 200.

    Article  PubMed  CAS  Google Scholar 

  12. Pearce J: The extrapyramidal disorder of Alzheimer’s disease. Europ Neurol 1974; 12: 94–103.

    Article  PubMed  CAS  Google Scholar 

  13. Molsa PK, Martilla R, Rinne UK: Extrapyramidal signs in Alzheimer’s disease. Neurology 1984; 34: 1114–6.

    PubMed  CAS  Google Scholar 

  14. Leverenz J, Sumi SM: Prevalence of Parkinson’s disease in patients with Alzheimer’s disease. Neurology 1984; 34: 101.

    Google Scholar 

  15. American Psychiatric Associationr Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Washington, D.C. 1980, pp. 205–24.

    Google Scholar 

  16. Hachinski VC, Iliff ID, Zhilka E, duBoulay GHD, McAllister VC, Marshall J, Russell RWR, Syinon L: Cerebral blood flow in dementia. Arch Neurol 1975; 32: 632–7.

    PubMed  CAS  Google Scholar 

  17. Lesser RP, Fahn S, Shider SR, Cote LJ, Isgreoi WP, Barrett RE: Analysis for the clinical problenns in parkinsonism and the complications of long-term levodopa therapy. Neurology 1979; 29: 1253–60.

    PubMed  CAS  Google Scholar 

  18. Blessed G, Tomlinson BE, Roth M: ihe association between quantitative measures of dementia and of senile changes in the cerdDral grey matter of elderly subjects. Brit J Psychiat 1968; 225: 797–811.

    Article  Google Scholar 

  19. Folstein MF, Folstein SE, McHugh PR: “Mini-Mental State” a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189–98.

    Article  PubMed  CAS  Google Scholar 

  20. Mayeux R, Stem Y, Rosen J, Leventhal J: Depression, intellectual iirpairment and Parkinson’s disease. Neurolocrv 1981; 31: 645–50.

    CAS  Google Scholar 

  21. Overall JE, Groham DR: The Brief Psychiatric Rating Scale. Psychol Rep 1962; 10: 799 - 812.

    Google Scholar 

  22. Rosenblum WI, Ghatak NR: Lewy bodies in the presence of Alzheimer’s disease. Arch Neurol 1979: 36: 170–1.

    PubMed  CAS  Google Scholar 

  23. Perl DP, Pendlebury WW, Bird ED: Detailed neuropathological evaluation of banked brain specimens submitted with a clinical diagnosis of Alzheimer’s disease. In: Wurtman RJ, Corkin SH, Growdon JH, eds. Alzheioner’s Disease: Advances in Basic Research and Therapies. Center for Brain Scioices and Metabolism Charitable Trust: Zurich, 1984: 463.

    Google Scholar 

  24. Alvord EC: The pathology of parkinsonism: etiologic, pathogenetic and pronostic implications. Trans Am Neurol Assoc 1965; 90: 167–8.

    PubMed  Google Scholar 

  25. Alvord EC, Forno LS, Kusske JA, Kauffman RJ, Rhodes JS, Goetowski CR: The pathology of parkinsaiism: A coirparison of degeneration in the cerebral; cortex and brain stem. Adv Neurol 1975; 5: 175–93.

    Google Scholar 

  26. Hakim AM, Mathieson G: Dementia in Parkinson disease: A neuropathologic study. Neurology 1979; 29: 1209–14.

    PubMed  CAS  Google Scholar 

  27. Boiler F, Mizutani T, Roessmann V, Gambetti P: Parkinson disease, dementia, and Alzheimer disease: Clinicopathological correlations. Ann Neurol 1980; 1: 329–35.

    Article  Google Scholar 

  28. Whitdiouse P, Hedreai JC White C, DeLong M, Price DL: Basal forebrain neurons in the dementia of Parkinson’s disease. Ann Neurol 1983; 13: 243–8.

    Article  PubMed  CAS  Google Scholar 

  29. Ruberg M, Ploska A, Javoy-Agid F, Agid Y: Muscarinic binding and choline acetyltransferase activity in parkinsonian subjects with reference to denaitia. Brain Res 1982; 232: 129–33.

    Article  PubMed  CAS  Google Scholar 

  30. Perry RH, Tomlinsai BE, Candy JM, Blessed G, Foster JF, Blaxham CA, Perry E: Cortical cholinergic deficit in mentally impaired parkinsonian patients. Lancet 1983; 309: 789–90.

    Article  Google Scholar 

  31. Mayeux R, Stern Y, Rosen J, Benson DF: Is subcortical dementia a recognizable clinical entity? Ann Neurol 1983; 14: 278–83.

    Article  PubMed  CAS  Google Scholar 

  32. Krai VA: Benign Senescent forgetfulness. In: Katzman R, Terry RD, Bick KL, eds. Alzheimer’s disease: Senile dementia and related disorders. New York: Raven Press, 1978: 47–51.

    Google Scholar 

  33. Tagliavini F, Pilleri G: Neuronal counts in basal nucleus of Meynert in Alzheimer disease and in simple senile dementia. Lancet 1983; 1: 469–70.

    Article  PubMed  CAS  Google Scholar 

  34. Berg L, Danziger WL, Storandt M, Coben LA, Gado M, Hughes CP, Knesevich JW, Botwinick J: Predictive features in mild soiile dementia of the Alzheimer type. Neurology 1984; 34: 563–9.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. College of Physicians and Surgeons Neurological Institute, Columbia University, 710 West 168th Street, New York, New York, 10032, USA

    Richard Mayeux & Yaakov Stern

Authors
  1. Richard Mayeux
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  2. Yaakov Stern
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Editor information

Editors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher  & Chaim Lachman  & 

  2. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin

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© 1986 Plenum Press, New York

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Mayeux, R., Stern, Y. (1986). Clinical Heterogeneity in Patients with Dementia of the Alzheimer Type. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_16

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  • DOI: https://doi.org/10.1007/978-1-4613-2179-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9283-8

  • Online ISBN: 978-1-4613-2179-8

  • eBook Packages: Springer Book Archive

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