Abstract
The cholinergic receptors are classically divided into two kinds, namely the nicotinic acetylcholine receptor and the muscarinic acetyl-choline receptor. The existence of these receptor types in the peripheral nervous system is well established. This is true also for the muscarinic receptors in the CNS. Attempts to study and characterize nicotinic receptors in brain have been initiated recently. Data on muscarinic receptors in the literature indicate similarities between rodent and human brain concerning number of binding sites and sub-populations (Birdsall et al., 1978; Nordberg and Winblad, 1981; Unden et al., 1983; Garrey et al., 1984). A comparison between fresh surgical and frozen autopsy samples (Unden et al, 1983) showed no difference in binding data, while Whitehouse et al. (1984), using a rat model of the human autopsy process, observed a significant decrease (18%)in Bmax after 48 h at room temperature. The muscarinic receptors seem to be more stable post mortem than the activity of choline acetyltransferase (ChAT) (Perry and Perry, 1980).
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References
Alafuzoff, E., Adolfsson, R., Grundki-Iqbal, I. and Winblad, B., 1985, Perivascular deposits of serum proteins in cerebral cortex in vascular dementia, Acta neuropathol. (Berlin), (in press).
Allen, S.J., Benton, J.S., Goodhardt, M.J., Haan, E.A., Sims, N.R., Smith, C.C.T., Spillane, J.A., Bowen, D.M., and Davison, A.N., 1983, Biochemical evidence of selective nerve cell changes in the normal ageing human and rat brain, J. Neurochem., 41: 256.
Antuono, P., Sorbi, S., Bracco, L., Fusco, T., and Amaducci, L., 1980, A discrete sampling technique in senile dementia of the Alzheimer type and alcoholic dementia: study of the cholinergic system, in: “Aging of the Brain and Dementia,” Aging vol. 13, L. Amaducci, A.N. Davison, P. Antuono, eds., Raven Press, New York.
Bartus, R.T., Dean, R.L., Beer, B., and Lippa, A.S., 1982, The cholinergic hypothesis of geriatric memory dysfunction, Science 217: 408.
Birdsall, N.J.M., Burgen, A.S.V., and Hulme, E.C., 1978, Multiple classes of muscarinic receptor binding sites in the brain, in: “Advances in Pharmacology and Therapeutics, vol. 1 Receptors,” J. Jacob, ed., Pergamon Press, Oxford, New York.
Bowen, D.M., Spillane, J.A., Curzon, G., Meier-Ruge, W., White, P., Goodhardt, M.J., Iwangoff, P., and Davison, A.N., 1979, Accelerated ageing or selective neuronal loss as an important cause of dementia?, Lancet, 1: 11.
Cuello, A.C., and Sofroniew, M.V., 1984, The anatomy of the CNS cholinergic neurons, TINS, 7: 74.
Davies, P., and Feisullin, S., 1981, Postmortem stability of i-bungaro- toxin binding sites in mouse and human brain, Brain Res, 216: 449.
Davies, P., and Verth, A., 1978, Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer’s type dementia brains, Brain Res, 138: 385.
Dubois, B., Ruberg, M., Javoy-Agid, F., Plosha, A., and Agid, Y., 1983, A subcortical-cortical cholinergic system is affected in Parkinson’s disease, Brain Res, 288: 213.
Garvey, J.M., Rossor, M., and Iversen, L.L., 1984, Evidence for multiple muscarinic receptor subtypes in human brain, J. Neurochem., 43: 299.
Hutton, J.T., 1980, Clinical nosology of the dementing illnesses, in: “Advances in Neurogerontology,” G.J. Maletta, F.J. Pirozzolo, eds., Praegen, New York.
Jenni-Eiermann, S., von Hahn, H.P., Honegger, C.G., and Ulrich, J., 1984, Studies on neurotransmitter binding in senile dementia, Gerontology, 30: 350.
Kohlmeyer, K., 1982, (Multiinfarct-)dementia versus primary degenerative (Alzheimer’s) dementia: A study of r-CBF and computed tomography (CT), in: “The Aging Brain,” S.Hoyer, ed., Springer-Verlag, Berlin, Heidelberg, New York.
Lang, H., and Henke, H., 1983, Cholinergic receptor binding and autoradiography in brains of non-neurological and senile dementia of Alzheimer-type patients, Brain Res, 267: 271.
Larsson, C., Lundberg, P-Å., Nordberg, A., Halen, A., and Adem, A., 1985, In vitro binding of 3H-acetylcholine to nicotine-like receptors in human and rodent brain, Acta Physiol. Scand., (submitted).
Larsson, C., and Nordberg, A., 1985, Comparative analysis of nicotine-like receptor - ligand interactions in rodent brain homogenate, J. Neurochem., (in press).
Larsson, C., and Nordberg, A., 1980, Studies of nicotine-like binding sites in brain, in: “Neurotransmitters and Their Receptors,” V.Z. Littauer, Y. Dudai, J. Silman, V.I. Vogel, eds., John Wiley amp; Sons Ltd.
Morley, B.J., and Kemp, G.E., 1981, Characterization of putative nicotinic acetylcholine receptor in mammalian brain, Brain Res. Rev., 3: 81.
Nordberg, A., Adolfsson, R., Aquilonius, S-M., Marklund, S., Oreland, L., and Winblad, B., 1980, Brain enzymes and acetylcholine receptors in dementia of Alzheimer type and chronic alcohol abuse, in: “Aging in the Brain and Dementia,” Aging vol. 13, L. Amaducci, A.N. Davison, P. Antuono, eds., Raven Press, New York.
Nordberg, A., Adolfsson, R., Marcusson, J., and Winblad, B., 1982a, Cholinergic receptors in the hippocampus in normal aging and dementia of Alzheimer type, in: The Aging Brain: “Cellular and Molecular Mechanisms of Aging in the Nervous system,” Aging vol. 20, E. Giacobini, G. Filogamo, G. Giacobini, A. Vernadakis, eds., Raven Press, New York.
Nordberg, A., Larsson, C., Adolfsson, R., Alafuzoff, I., and Winblad, B., 1983, Muscarinic receptor compensation in hippocampus of Alzheimer patients, J. Neural. Transmission, 56: 13.
Nordberg, A., Larsson, C., Perdahl, E., and Winblad, B., 1982b, Cholinergic activity in hippocampus in chronic alcoholism, Drug and Alcohol Dependence, 10: 333.
Nordberg, A., Marcusson, J., and Winblad, B., 1985a, 3H-QNB binding in human hippocampus - selective increase of 3H-nicotine sites with age. To be submitted.
Nordberg, A., Nyberg, P., and Winblad, B., 1985b, Topochemical distribution of choline acetyltransferase activity, muscarinic and nicotinic receptors in Parkinson brains. To be submitted.
Nordberg, A., and Winblad, B., 1981, Cholinergic receptors in human hippocampus-regional distribution and variance with age, Life Sci, 29: 1937.
Palacios, J.M., 1982, Autoradiographic localization of muscarinic cholinergic receptors in the hippocampus of patients with senile dementia, Brain Res, 243: 173.
Perry, E., 1980, The cholinergic system in old age and Alzheimer’s disease, Age and Aging, 9: 1.
Perry, E.K., and Perry, R.H., 1980, The cholinergic system in Alzheimer’s disease, in: “Biochemistry of Dementia,”P.H. Roberts, ed., John Wiley amp; Sons Ltd.
Perry, E.K., Perry, R., Blessed, G., and Tomlinson, B., 1977, Necropsy evidence of central cholinergic deficits in senile dementia, Lancet, 1: 189.
Perry, E.K., Perry, R.H., Gibson, P., Blessed, G., and Tomlinson, B.E., 1977, A cholinergic connection between normal aging and senile dementia in the human hippocampus, Neuroscience Letters, 6: 85.
Reisberg, B., and Ferris, S.H., 1982, Diagnosis and assessment of the older patient, Hosp. Com. Psychiat., 33: 104.
Reisine, T.D., Yamamura, H.I., Bird, E.D., Spokes, E., and Enna, S.J.,1978, Pre-and postsynaptic neurochemical alterations in Alzheimer’s disease, Brain Res, 159: 477.
Rinne, J.O., Rinne, J.K., Laakso, K., Paljärvi, L., and Rinne, V.K., 1984, Reduction in muscarinic receptor binding in limbic areas of Alzheimer brain, J. Neurol. Neurosurg, Psychiat., 47: 651.
Schwartz, R.D., McGee, R., and Kellar, K.J., 1982, Nicotinic cholinergic receptors labelled by 3H-acetylcholine in rat brain, Mol. Pharmacol., 22: 56.
Undén, A., Meyerson, B., Winblad, B., Sachs, C. and Bartfai, T., 1983, Postmortem changes in binding to the muscarinic receptor from human cerebral cortex, J. Neurochem., 41: 102.
Volpe, B., Francis, A., Gazzaniga, M.S., and Schechter, N., 1979, Regional concentration of putative nicotinic - cholinergic receptor sites in human brain, Exp. Neurol., 66: 737.
White, P., Goodhardt, M.J., Keet, J.P., Hiley, C.R., Carrasco, L.H., and Williams, I.E.I., 1977, Neocortical cholinergic neurons in elderly people, Lancet, 1: 668.
Whitehouse, P.J., Lynch, D., and Kuhar, M.J., 1984, Effects of postmortem delay and temperature on neurotransmitter receptor binding in a rat model of the human autopsy process, J. Neurochem., 43: 553.
Wood, P.L., Etienne, P., Lai, S., Nair, N.P.V., Finlayson, M.H., Gauthier, S., Palo, J., Haltia, M., Paetau, A., and Bird, E.D., 1983, A post-mortem comparison of the cortical cholinergic system in Alzheimer’s disease and Pick’s disease, J. Neurol. Sci., 62: 211.
Yates, C.M., Simpson, J., Maloney, A.F.J., and Gordon, A., 1980, Neurochemical observations in a case of Pick’s disease, J. Neurol. Sci., 48: 257.
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© 1986 Plenum Press, New York
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Nordberg, A., Winblad, B. (1986). Brain Nicotinic and Muscarinic Receptors in Normal Aging and Dementia. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_12
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DOI: https://doi.org/10.1007/978-1-4613-2179-8_12
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