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Gangliosides as antigens of human melanoma

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Malignant Melanoma: Biology, Diagnosis, and Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 43))

Abstract

Gangliosides, the glycosphingolipids containing sialic acids, are fundamental constituents of vertebrate cells [1]. Gangliosides are located on the cell membrane, with the carbohydrate moiety exposed outside the cell surface and the lipid portion embedded in the bilayer lipid membrane. Gangliosides are most abundant in neural tissues but are also found in small quantities in other cells [2, 3]. Many different types of gangliosides have been identified in human tissues. The ganglioside composition differs among different normal tissues as well as among different forms of cancers.

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Authors
  1. Mepur H. Ravindranath
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  2. Reiko F. Irie
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Editors and Affiliations

  1. Winthrop-University Hospital, Mineola, New York, USA

    Larry Nathanson

  2. Department of Medicine, Health Science Center, SUNY, Stony Brook, New York, USA

    Larry Nathanson

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© 1988 Kluwer Academic Publishers, Boston

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Ravindranath, M.H., Irie, R.F. (1988). Gangliosides as antigens of human melanoma. In: Nathanson, L. (eds) Malignant Melanoma: Biology, Diagnosis, and Therapy. Cancer Treatment and Research, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1751-7_2

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  • DOI: https://doi.org/10.1007/978-1-4613-1751-7_2

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