Abstract
Studies were undertaken to define the relative importance of mechanisms by which cisplatin can enhance the effects of radiation treatments. In a mouse tumour and in three different normal tissues, the magnitudes of (a) cell killing by the drug, (b) radiosensitization, (c) inhibition of X ray damage repair, and (d) inhibition of proliferation were investigated. The last two mechanisms would be particularly important in fractionated treatments. These studies were therefore designed to test whether a therapeutic advantage could be obtained by combining cisplatin and irradiation and, if so, by which mechanisms this was achieved.
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© 1988 Martinus Nijhoff Publishing, Boston
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Begg, A.C., Stewart, F.A., Dewit, L., Bartelink, H. (1988). Cisplatin-Radiation Interactions in Tumours and Normal Tissues. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_7
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_7
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