Abstract
Pascoe and Roberts (1) first observed DNA-DNA interstrand crosslinks in cultured HeLa cells which had been treated with cisplatin using density gradient techniques. Zwelling and coworkers (2) subsequently showed using alkaline elution that interstrand crosslinks formed by cis-DDP (cis-PtCl2(NH3)2) in L1210 leukemia cells evolved as a function of time during post-treatment incubation and reached a maximum 6–12 h after treatment. These results have been confirmed in cultured human fibroblasts treated with cisplatin by means of alkaline elution and DNA renaturation techniques (3). The appearance of DNA interstrand crosslinks during post-treatment incubation is thought to be the result of the transformation of monofunctional platinum-DNA adducts into bifunctional lesions (4).
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References
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© 1988 Martinus Nijhoff Publishing, Boston
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Johnson, N.P., Lapetoule, P., Razaka, H., Butour, J.L. (1988). Kinetics of Formation of Genotoxic Platinum-DNA Lesions in Vivo . In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_1
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