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Prediction of Protein Structural Classes from Amino Acid Compositions

  • Chapter
Prediction of Protein Structure and the Principles of Protein Conformation

Abstract

Proteins are simple and yet quite complex biological macromolecules. They are simple because their building blocks are the 20 naturally occurring amino acids. They are complex because these different amino acid sequences can assume an infinite variety of spatial conformations. Fortunately, there is a link between the simple and the complex in that the protein’s conformation is coded in its amino acid sequence. This was demonstrated by the classical experiments on ribonuclease refolding (Anfinsen et al., 1961) that showed that the information for the protein’s three-dimensional architecture resides in the primary structure alone.

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    Peter Y. Chou

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  1. Graduate Department of Biochemistry, Brandeis University, Waltham, Massachusetts, 02254, USA

    Gerald D. Fasman

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© 1989 Plenum Press, New York

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Chou, P.Y. (1989). Prediction of Protein Structural Classes from Amino Acid Compositions. In: Fasman, G.D. (eds) Prediction of Protein Structure and the Principles of Protein Conformation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1571-1_12

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  • DOI: https://doi.org/10.1007/978-1-4613-1571-1_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8860-2

  • Online ISBN: 978-1-4613-1571-1

  • eBook Packages: Springer Book Archive

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