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Mammals I: Regulation of RAS Activation

  • Chapter
Regulation of the RAS Signaling Network

Abstract

The discovery of the RAS oncogene was one of the pivotal events in modern cancer research.1–3 However, the importance of the discovery was in many ways due to our knowledge of hormone action and the role of G-proteins in signaling.4 v-Ha-RAS was known to bind GTP and become phosphorylated when the GTP was hydrolyzed to GDP.5 The similarity between the possible actions of RAS-GTP and other members of the G-protein system was noticed soon after the identification of c-Ha-RAS and its ability to hydrolyze GTP.4–6

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Authors
  1. Antony W. Burgess
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© 1996 R.G. Landes Company

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Burgess, A.W. (1996). Mammals I: Regulation of RAS Activation. In: Regulation of the RAS Signaling Network. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1183-6_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1183-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8502-1

  • Online ISBN: 978-1-4613-1183-6

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