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Genetics of RAS Signaling in Drosophila

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Regulation of the RAS Signaling Network

Abstract

As in other multicellular organisms, RAS proteins play a key role in the signaling pathways that regulate cell growth and differentiation in Drosophila. Although these proteins were first identified in Drosophila using cross-species hybridization, it has been the use of classical genetics which has overwhelmingly driven investigations of RAS function in Drosophila. This focus has been successful in placing RAS in complex signaling pathways for several reasons: genetic screens generally make no assumptions about the biochemical activity of the components of the signaling pathway, thereby facilitating the isolation of proteins with novel activities; a functional requirement for the protein in the pathway is established at the outset, which is often lacking when proteins are isolated by other means; and tests of cell autonomy and epistasis frequently position the requirement for the protein in the pathway, even before its biochemical activity is known.

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Bowtell, D.D.L. (1996). Genetics of RAS Signaling in Drosophila . In: Regulation of the RAS Signaling Network. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1183-6_1

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  • DOI: https://doi.org/10.1007/978-1-4613-1183-6_1

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