Skip to main content
SpringerLink
Log in

Nickel

  • Chapter
Biological Monitoring of Toxic Metals

Part of the book series: Rochester Series on Environmental Toxicity ((RSET))

Abstract

This chapter represents a synopsis of nickel toxicology, with particular emphasis on biological monitoring of persons exposed to nickel compounds or alloys from occupational, environmental, and iatrogenic sources. The discussions in this chapter are condensed from recent reviews by the author and his collaborators (Sunderman, 1984a,b; 1986a,b; Sunderman et al., 1986a). For additional information on biological effects of nickel readers may consult monographs and articles by Bencko (1983); Brown and Sunderman (1980, 1985); Costa and Heck (1985); Leonard et al. (1981); Mas et al. (1985); Mushak (1984); Norseth (1984); Nriagu (1980); Oskarsson (1984); Rigaut (1983); Raithel and Schaller (1981); Schaller et al. (1982); and Sunderman et al. (1984a).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Abulwajid, A.W. and Sakar, B., 1983, Nickel-sequestering, renal glycoprotein, Proc. Nat. Acad. Sci., USA, 80: 4509–4512.

    Google Scholar 

  • Adams, D.B., 1980, The routine determination of nickel and creatinine in urine, in. “Nickel Toxicology,” S.S. Brown and F.W. Sunderman Jr., eds., pp. 99–102, Academic Press, London.

    Google Scholar 

  • Aitio, A., 1984, Biological monitoring of occupational exposure to nickel, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 497–505, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Aitio, A. and Jarvisalo, J., 1986, Levels of welding fume components tissues and body fluids, in: “Health Hazards and Biological Effects of Welding Fumes and Gases,” R.M. Stern, A. Berlin, A.C. Fletcher and J. Jarvisalo, eds., pp. 169–180, Elsevier, Amsterdam.

    Google Scholar 

  • Aitio, A., Tossavainen, A, Gustafsson, T., Kiilunen, M., Haapa, K. and Jarvisalo, J., 1985, Urinary excretion of nickel and chromium in workers of a steel foundry, in: “Progress in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 149–152, Blackwell, Oxford.

    Google Scholar 

  • Akesson, B. and Skerfving, S., 1985, Exposure in welding of high nickel alloy, Intern. Arch. Occup. Environ. Health, 56: 111–117.

    CAS  Google Scholar 

  • Aldridge, R.D., Milton, J.I. and Thomson, A.W., 1985, Leukocyte procoagulant activity as an in vitro index of nickel contact hypersensitivity, Intern. Arch. Allergy Appl. Immunol., 76: 350–353.

    CAS  Google Scholar 

  • Asato. N. van Soestbergen, M. and Sunderman, F.W., Jr., 1975, Binding of 63Ni(II) to ultrafiltrable constituents of rabbit serum in vivo and in vitro, Clin. Chem., 21: 521–527.

    PubMed  Google Scholar 

  • Bencko, V., 1983, Nickel: A review of its occupational and environmental toxicology, J. Hyg. Epidemiol. Microbiol. Immunol., 27: 237–247.

    Google Scholar 

  • Bennett, B.G., 1984, Environmental nickel pathways to man, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 787–495, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Bernacki, E.J., Parsons, G.E., Roy, B.R., Mikac-Devic, M., Kennedy, C.D., and Sunderman, F.W., Jr., 1978, Urine nickel concentrations in nickel- exposed workers, Ann. Clin. Lab. Sci., 8: 184–189.

    PubMed  CAS  Google Scholar 

  • Bernacki, E.J., Zygowicz, E. and Sunderman, F.W., Jr., 1980, Fluctuations of nickel concentrations in urine of electroplating workers, Ann. Clin. Lab. Sci., 10: 33–39.

    PubMed  CAS  Google Scholar 

  • Black, J., Maitin, E.C., Gelman, H. and Morris, D.M., 1983, Serum concentrations of chromium, cobalt and nickel after total hip replacement: a six month study, Biomaterials, 4: 160–164.

    PubMed  CAS  Google Scholar 

  • Boysen, M., Solberg, L.A., Andersen, I., Hogetveit, A.C. and Torjussen, W., 1982, Nasal histology and nickel concentration in plasma and urine after improvements in working environment at a nickel refinery in Norway, Scand. J. Work. Environ. Health, 8: 283–289.

    PubMed  CAS  Google Scholar 

  • Boysen, M., Solberg, L.A., Torjussen, W., Poppe, S. and Hogetveit, A.C., 1984, Histological changes, rhinoscopical findings and nickel concentrations in plasma and urine in retired nickel workers, Acta Otolaryngol, 97: 105–115.

    PubMed  CAS  Google Scholar 

  • Brown, S.S. and Sunderman, F.W., Jr., eds., 1980, “Nickel Toxicology,” Academic Press, London.

    Google Scholar 

  • Brown, S.S. and Sunderman, F.W., Jr., eds., 1985, “Progress in Nickel Toxicology,” Blackwell, Oxford.

    Google Scholar 

  • Brown, S.S., Nomoto, S., Stoeppler, M. and Sunderman, F.W., Jr., 1981, IUPAC reference method for analysis of nickel in serum and urine by electrothermal atomic absorption spectrophotometry, Clin. Biochem., 14: 295–299.

    PubMed  CAS  Google Scholar 

  • Callan, M.W. and Sunderman, F.W., Jr., 1973, Species variations in binding of 63Ni(II) by serum albumin, Res. Comm. Chem. Pathol. Pharmacol., 5: 459–472.

    CAS  Google Scholar 

  • Camner, P., Casarett-Bruce, M., Curstedt, T., Jarstrand, C., Wiernik, A., Johansson, A., Lundborg, M. and Robertson, B., 1984, Toxicology of nickel, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 267–276, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Catalanatto, F.A., Sunderman, F.W., Jr. and Macintosh, T.R., 1977, Nickel concentrations in human parotid saliva, Ann. Clin. Lab. Sci., 7: 146–151.

    PubMed  CAS  Google Scholar 

  • Christensen, O.B. and Lagesson, V., 1981, Nickel concentration of blood and urine after oral administration, Ann. Clin. Lab. Sci., 11: 119–125.

    PubMed  CAS  Google Scholar 

  • Christensen, O.B., Moller, H., Andrasko, L. and Lagesson, V., 1979, Nickel concentration of blood, urine and sweat after oral administration, Contact Dermatitis, 5: 312–316.

    PubMed  CAS  Google Scholar 

  • Clary, J.J., 1975, Nickel chloride-induced metabolic changes in the rat and guinea pig, Toxicol. Appl. Pharmacol., 31: 55–56.

    PubMed  CAS  Google Scholar 

  • Clemente, F.G., Cigna-Rossi, L. and Santaroni, G.P., 1980, Nickel in foods and dietary intake of nickel, in: “Nickel in the Environment,” J.O. Nriagu, ed., pp. 493–498, John Wiley, New York.

    Google Scholar 

  • Cohn, J.R. and Emmett, E.A., 1978, The excretion of trace metals in human sweat, Ann. Clin. Lab. Sci., 8: 270–275.

    PubMed  CAS  Google Scholar 

  • Costa, M. and Heck, J.D., 1985, Perspectives on the mechanism of nickel carcinogenesis, Advan. Inorgan. Biochem., 6: 285–309.

    Google Scholar 

  • Cronin, E., Di Michiel, A.D. and Brown, S.S., 1980, Oral challenge in nickel- sensitive women with hand eczema, in: “Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 149 - 152, Academic Press, London.

    Google Scholar 

  • Cross, J.E., Hughes, D.M. and Williams, D.R., 1985, Critical review of the evidence for nickel (III) in animals and man, in: “Progress in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 109–112, Blackwell, Oxford.

    Google Scholar 

  • Decsy, M.I. and Sunderman, F.W., 1974, Binding of 63Ni to rabbit serum α-2 macroglobulin in vivo and in vitro, Bioinorg. Chem., 3: 95–105.

    PubMed  CAS  Google Scholar 

  • Dielert, E., Milachowski, K. and Schramel, P., 1983, The role of the alloy- specific elements iron, cobalt, chromium and nickel in aseptic loosening of total hip joint prosthesis, Z. Orthop., 121: 58–63.

    PubMed  CAS  Google Scholar 

  • Dobbs, H.S. and Minski, M.J., 1982, Metal ion release after total hip replacement, in: “Biomaterials,” G.D. Winter, D.F. Gibbons, and H. Plenk, Jr., eds., pp. 255–263, Wiley, Ltd., New York.

    Google Scholar 

  • Doll, R., 1984, Nickel exposure: a human health hazard, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 3–21, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Donskoy, E., Donskoy, M., Farouhar, F., Gillies, C.G., Marzouk, A., Reid, M.C., Zaharia, O. and Sunderman, F.W., Jr., 1986, Hepatic toxicity of nickel chloride in rats, Ann. Clin. Lab. Sci, 16: 108–113.

    PubMed  CAS  Google Scholar 

  • Drazniowsky, M., Channon, S.M., Parkinson, I.S., Ward, M.K., Poon, T.F.H., and Kerr, D.N.S., 1985, The measurement of nickel in chronic renal failure, in: “Progress in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 141–144, Blackwell, Oxford.

    Google Scholar 

  • Ellen, G., van den Bosch-Tibbesma, G. and Douma, F.F., 1978, Nickel content of various Dutch foodstuffs, Z. Lebensm. Unters. Forsch., 166: 145–147.

    CAS  Google Scholar 

  • Feeley, R.M., Eitenmiller, R.R., Jones, J.B., Jr. and Barnhart, H., 1983, Manganese, cobalt, nickel, silicon and aluminum in human milk during early lactation, Fed. Proc., 42: 931.

    Google Scholar 

  • Fernandez de Corres, L., Garrastazu, M.T., Soloeta, R. and Escayol, P., 1982, Nickel contact dermatitis in a blood bank, Contact Dermatitis, 8: 32–37.

    Google Scholar 

  • Fine, J.M., Abdo, Y., Rochu, D., Rousseaux, J. and Uautrevaux, M., 1983, Identification of the human albumin variant “Gainesville” with proalbumin “Christchurch,” Blood Trans. Immunohematol., 26: 341–346.

    CAS  Google Scholar 

  • Flyvholm, M.A., Neil sen, G.D. and Andersen, A., 1984, Nickel content of food and estimation of dietary intake, Z. Lebensm. Unters. Forsch., 179: 427–431.

    PubMed  CAS  Google Scholar 

  • Foffani, M.T., Mammi, S., Michielin, L. and Peggion, E., 1985, Macro-molecularization of a tripeptide analogue of the Cu(II) binding site of human serum albumin. 2. Conformational and binding properties towards Cu(II) and Ni(II) ions of Gly-Gly-His derivatives of poly(L-lysine), Int. J. Biol. Macromol., 7: 370–378.

    CAS  Google Scholar 

  • Foulkes, E.C., 1985, Interaction between metals in rat jejunum: Implications on the nature of cadmium uptake, Toxicology, 37: 117–125.

    PubMed  CAS  Google Scholar 

  • Foulkes, E.C. and McMullen, D.M., 1986, On the mechanism of nickel absorption in the rat jejunum, Toxicology, 38: 35–42.

    PubMed  CAS  Google Scholar 

  • Gitlitz, P.H., Sunderman, F.W., Jr. and Goldblatt, P.J., 1975, Aminoaciduria and proteinuria in rats after a single intraperitoneal injection of Ni(II), Toxicol. Appl. Pharmacol., 34: 430–440.

    PubMed  CAS  Google Scholar 

  • Glennon, J.D. and Sarkar, B., 1982, Nickel(II) transport in human blood serum, Biochem. J., 203: 15–23.

    PubMed  CAS  Google Scholar 

  • Grandjean, P., 1984, Human exposure to nickel, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 469–485, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Grandjean, P., Selikoff, I.J., Shen, S.K. and Sunderman, F.W., Jr., 1980, Nickel concentrations in plasma and urine of shipyard workers, Amer. J. Indust. Med., 1: 181–189.

    CAS  Google Scholar 

  • Hagedorn-Gotz, H., Kuppers, G. and Stoeppler, M., 1977, On nickel contents in urine and hair in a case of exposure to nickel carbonyl, Arch. Toxicol., 38: 275–285.

    PubMed  CAS  Google Scholar 

  • Hansen, J.A. and Tjell, J.C., 1981, Trace metals in human excreta, in: “Slammets Jordbruganvendelse II,” Polytenkisk Forlag, Copenhagen.

    Google Scholar 

  • Hassler, E., Lind, B., Nilsson, B. and Piscator, M., 1983, Urinary and fecal elimination of nickel in relation to air-borne nickel in a battery factory, Ann. Clin. Lab. Sci., 13: 217–224.

    PubMed  CAS  Google Scholar 

  • Hierholzer, S., Hierholzer, G., Sauer, K.H. and Paterson, R.S., 1984, Increased corrosion of stainless steel implants in infected plated fractures, Arch. Orthop. Trauma Surg., 102: 198–200.

    PubMed  CAS  Google Scholar 

  • Hildebrand, H.F., Herl ant-Peers, M.C., Stoeppler, M., Bagschik, U. and Roggatz, J., 1982, The long-term effects of a centro-medullary pin of chrome-nickel alloy, in: Proc. 15th Nat. Hildebrand, H.F., Herl ant-Peers, M.C., Stoeppler, M., Bagschik, U. and Roggatz, J., eds., pp. 124–126, Lille.

    Google Scholar 

  • Hildebrand, H.F., Roumazeille, B., Decoulx, J., Herl ant-Peers, M.C., Ostapczuk, P., Stoeppler, M. and Mercier, J.M., 1985, Biological consequences of long-term exposure to orthopedic implants, in: “Progess in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 169–172, Blackwell, Oxford.

    Google Scholar 

  • Hogetveit, A.C. and Barton, R.T., 1977, Monitoring nickel exposure in refinery workers, in: “Clinical Chemistry and Chemical Toxicology in Metals,” S.S. Brown, ed., pp. 265–268, Elsevier, Amsterdam.

    Google Scholar 

  • Hogetveit, A.C., Barton, R.T. and Kostol, C.O., 1978, Plasma nickel as a primary index of exposure in nickel refining, Ann. Occup. Hyg., 21: 113–120.

    PubMed  CAS  Google Scholar 

  • Hogetveit, A.C., Barton, R.T. and Andersen, I., 1980, Variations of nickel in plasma and urine during the work period, J. Occup. Med., 22: 597–600.

    PubMed  CAS  Google Scholar 

  • Hohnadel, D.C., Sunderman, F.W., Jr., Nechay, M.W. and McNeely, M.D., 1973, Atomic absorption spectrometry of nickel, copper, zinc, and lead in sweat from healthy subjects during sauna bathing, Clin. Chem., 19: 1288–1292.

    PubMed  CAS  Google Scholar 

  • Hopfer, S.M., Sunderman, F.W., Jr., Reid, M.C. and Goldwasser, E., 1984a, Increased immunoreactive erythropoietin in serum and kidney extracts of rats with Ni3S2-induced erythrocytosis, Res. Commun. Chem. Pathol. Pharmacol., 43: 299–305.

    PubMed  CAS  Google Scholar 

  • Hopfer, S.M., Sunderman, F.W., Jr., McCully, K.S., Reid, M.C., Liber, C., Spears, J.R. and Serur, J., 1984b, Studies of the pathogenesis of arteriosclerosis induced in rats by intrarenal injection of a carcinogen, nickel subsulfide, Ann. Clin. Lab. Sci., 14: 355 - 365.

    PubMed  CAS  Google Scholar 

  • Hopfer, S.M., Linden, J.V., Crisostomo, M.C., O’Brien, J.E. and Sunderman, F.W., Jr., 1984c, Hypernickelemia in patients receiving disulfiram, Ann. Clin. Lab. Sci., 14: 319–320.

    Google Scholar 

  • Hopfer, S.M., Linden, J.V., Crisostomo, M.C., Catalanatto, F.A., Galen, M., and Sunderman, F.W., Jr., 1985a, Hypernickelemia in hemodialysis patients, Trace Element Med, 2: 68–72.

    Google Scholar 

  • Hopfer, S.M., Sunderman, F.W., Jr. and Goldwasser, E., 1985b, Effects of unilateral intrarenal administration of nickel subsulfide to rats on erythropoietin concentrations in serum and in extracts of both kidneys, in: “Progress in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 97 - 100, Blackwell, Oxford.

    Google Scholar 

  • Horak, E. and Sunderman, F.W., Jr., 1973, Fecal nickel excretion by healthy adults, Clin. Chem., 19: 429–430.

    PubMed  CAS  Google Scholar 

  • Horak, E. and Sunderman, F.W., Jr., 1975a, Effects of Ni(II), other divalent metal ions, and glucagon upon plasma glucose concentrations in normal, adrenalectomized and hypophysectomized rats, Toxicol. Appl. Pharmacol., 32: 316–329.

    PubMed  CAS  Google Scholar 

  • Horak, E. and Sunderman, F.W., Jr., 1975b, Effects of Ni(II) upon plasma glucagon and glucose in rats, Toxicol. Appl. Pharmacol., 33: 388–391.

    PubMed  CAS  Google Scholar 

  • Horak, E., Zygowicz, E.R., Tarabishy, R., Mitchell, J.M. and Sunderman, F.W., Jr., 1978, Effects of nickel chloride and nickel carbonyl upon glucose metabolism in rats, Ann. Clin. Lab. Sci., 8: 476–482.

    PubMed  CAS  Google Scholar 

  • Horie, A., Haratake, J., Tanaka, I., Kodama, Y. and Tsuchiya, K., 1985, Electron microscopical findings with special reference to cancer in rats caused by inhalation of nickel oxide, Biol. Trace Elem. Res., 7: 223–239.

    CAS  Google Scholar 

  • IARC (International Agency for Research on Cancer), 1976, Nickel and nickel compounds, in: “Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Man,” pp. 75–112, IARC Publishing Office, Lyon.

    Google Scholar 

  • Izmerov, N.F., 1984, “Nickel and its Compounds,” pp. 1–36, Centre of International Projects, State Committee for Science and Technology (GKNT), Moscow.

    Google Scholar 

  • Jasmin, G. and Riopelle, J.L., 1976, Renal carcinomas and erythrocytosis in rats following intrarenal injection of nickel subsulfide, Lab. Invest., 35: 71–78.

    PubMed  CAS  Google Scholar 

  • Kalliomaki, P.L., Rahkonen, E., Vaaranen, V., Kalliomaki, K. and Aittoniemi, K., 1981, Lung retained contaminants, urinary chromium and nickel among stainless steel workers, Intern. Arch. Occup. Environ. Health, 49: 66–75.

    Google Scholar 

  • Kieffer, M., 1979, Nickel sensitivity: relationship between history and patch test reaction, Contact Dermatitis, 5: 398–401

    PubMed  CAS  Google Scholar 

  • Kollmeier, H., Wittig, C., Seemann, J., Wittig, P. and Rothe, R., 1985, Increased chromium and nickel content in lung tissue, J. Cancer Res. Clin. Oncol., 110: 173–176.

    PubMed  CAS  Google Scholar 

  • Kotlar, H.K., Boysen, M. and Sanner, T., 1982, A serum immune factor in detection of an occupational group with increased risk for lung and nose cancer, Europ. J. Cancer Clin. Oncol., 18: 957–965.

    PubMed  CAS  Google Scholar 

  • Lachapelle, J.M. and Tennstedt, D., 1982, An anatomo-clinical study of delayed skin allergic reactions to nickel following intradermal injections of lidocaine with a Dermo-Jet, Contact Dermatitis, 8: 193–199.

    PubMed  CAS  Google Scholar 

  • Lauwerys, R.L., 1983, “Industrial Chemical Exposure: Guidelines for Biological Monitoring,” pp. 1–150, Biomedical Publications, Davis.

    Google Scholar 

  • Leach, C.N., Jr. and Sunderman, F.W., Jr., 1985, Nickel contamination of human serum albumin solutions, New Engl.J. Med., 313: 1232.

    PubMed  Google Scholar 

  • Leach, C.A., Jr. and Sunderman, F.W., Jr., 1987, Hypernickelemia induced by nickel contamination of radiographic contrast media, Ann. Clin. Lab. Sci., in press.

    Google Scholar 

  • Leonard, A., Gerber, G.B. and Jacquet, P., 1981, Carcinogenicity, mutagenicity and teratogenicity of nickel, Mutat. Res., 87: 1–15.

    PubMed  CAS  Google Scholar 

  • Linden, J.V., Hopfer, S.M., Gosslig, H.R. and Sunderman, F.W., Jr., 1985, Blood nickel concentrations in patients with stainless-steel hip prostheses, Ann. Clin. Lab. Sci., 15: 459–463.

    PubMed  CAS  Google Scholar 

  • Maines, M.D. and Kappas, A., 1977, Metals as regulators of heme metabolism, Science, 198: 1215–1221.

    PubMed  CAS  Google Scholar 

  • Marzouk, A. and Sunderman, F.W., Jr., 1985, Biliary excretion of nickel in rats, Toxicol. Lett., 27: 65–71.

    PubMed  CAS  Google Scholar 

  • Mas, A., Holt, D. and Webb, M., 1985, The acute toxicity and teratogenicity of nickel in pregnant rats, Toxicology, 35: 47–57.

    PubMed  CAS  Google Scholar 

  • McEwan, J.C., 1978, Five-year review of sputum cytology in workers at a nickel sinter plant, Ann. Clin. Lab. Sci., 8: 503.

    Google Scholar 

  • Meininger, J. and Dautzenberg, B., 1985, Health surveillance of SLN workers, in: “Progress in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 223–226, Blackwell, Ltd., Oxford.

    Google Scholar 

  • Menne, T., 1978, The prevalence of nickel allergy among women, Berufsdermatosen, 26: 123–125.

    CAS  Google Scholar 

  • Mingorance, M.D. and Lachica, M., 1985, Direct determination of some trace elements in milk by electrothermal atomic absorption spectometry, Anal. Lett., 18: 1519–1531.

    CAS  Google Scholar 

  • Morgan, L.G. and Rouge, P.J.C., 1979, A study into the correlation between atmospheric and biological monitoring of nickel in nickel refinery workers, Ann. Occup. Hyg., 22: 311–317.

    PubMed  CAS  Google Scholar 

  • Morgan, L.G. and Rouge, P.J.C., 1984, Biological monitoring in nickel refinery workers, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 507–520, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Mushak, P., 1984, Nickel metabolism in health and disease, in: “Clinical Laboratory Annual,” H.H. Homburger and J.G. Batsakis, eds., pp. 249 - 269, Appleton-Century Crofts, Norwalk.

    Google Scholar 

  • Myron, D.R., Zimmerman, T.J., Shuler, T.R., Klevay, L.M., Lee, D.E. and Nielsen, F.H., 1978, Intake of nickel and vanadium of humans. A survey of selected diets, Amer. J. Clin. Nutr., 31: 527–531.

    PubMed  CAS  Google Scholar 

  • Nechay, M.W. and Sunderman, F.W., Jr., 1973, Measurements of nickel in hair in atomic absorption spectrometry, Ann. Clin. Lab. Sci., 3: 30–35.

    PubMed  CAS  Google Scholar 

  • Nieboer, E., Stetsko, P.I. and Hin, P.Y., 1984, Characterization of the Ni[III]/Ni[II] redox couple for the Ni[Ill-complex of human serum albumin, Ann. Clin. Lab. Sci., 14: 409.

    Google Scholar 

  • NIOSH (National Institute for Occupational Safety and Health), 1977, “Criteria for a Recommended Standard: Occupational Exposure to Inorganic Nickel,” (DHEW-NIOSH Document No. 77–164), pp. 1 - 282, U.S. Government Printing Office, Washington, D.C.

    Google Scholar 

  • Nomoto, S., Decsy, M.I., Murphy, J.R. and Sunderman, F.W., Jr., 1973, Isolation of 63Ni-labeled nickeloplasmin from rabbit serum, Biochem. Med., 8: 171–181.

    PubMed  CAS  Google Scholar 

  • Nordlind, K., 1984, Further studies on the lymphocyte transformation test in diagnosis of nickel allergy. Effect of fractionation of lymphocytes into different subpopulations on the basis of density, Intern. Arch. Allergy Appl. Immunol., 75: 333–336.

    CAS  Google Scholar 

  • Norseth, T., 1984, Chromium and nickel, in: “Biological Monitoring and Surveillance of Workers Exposed to Chemicals,” A. Aitio, V. Riihimaki, and H. Vainio, eds., pp. 49–59, Hemisphere Press, Washington, D.C. Nriagu, J.O, ed., 1980, “Nickel in the Environment,” Wiley, New York.

    Google Scholar 

  • O’Del , G.D., Miller, W.J., King, W.A., Moore, S.L. and Blackmon, D.M., 1970, Nickel toxicity in the young bovine, J. Nutr., 100: 1447–1454.

    Google Scholar 

  • Onkelinx, C. and Sunderman, F.W., Jr., 1980, Modeling of nickel metabolism, in: “Nickel in the Environment,” J.O. Nriagu, ed., pp. 525 - 545, Wiley Tnterscience, New York.

    Google Scholar 

  • Oskarsson, A., 1984, Nickel, in: “Metalle in der Umwelt,” E. Merian, ed., pp. 487–497, Verlag Chemie, Weinheim.

    Google Scholar 

  • Oskarsson, A. and Tjalve, H., 1979, Binding of 63Ni by cellular constituents in some tissues of mice after the administration of 63NiCl2, Acta Pharmacol.Toxicol., 45: 306–314.

    Google Scholar 

  • Ostapczuk, P., Valenta, P., Stoeppler, M. and Nürnberg, H.W., 1983, Voltammetric determination of nickel and cobalt in body fluids and other biological materials, in: “Chemical Toxicology and Clinical Chemistry of Metals,” S.S. Brown and J. Savory, eds., pp. 61–64, Academic Press, London.

    Google Scholar 

  • Pazzaglia, U.E., Minoia, C., Ceciliani, L. and Riccardi, C., 1983, Metal determination in organic fluids of patients with stainless steel hip arthroplasty, Acta Orthop. Scand., 54: 574–579.

    PubMed  CAS  Google Scholar 

  • Pederson, E., Hogetveit, A.C. and Anderson, A., 1973, Cancer of respiratory organs among workers at a nickel refinery in Norway, Intern. J. Cancer, 12: 32–41.

    Google Scholar 

  • Peltonen, L., 1979, Nickel sensitivity in the general population, Contact Dermatitis, 5: 27–32.

    PubMed  CAS  Google Scholar 

  • Peto, J, Cuckle, H., Doll, R., Hermon, C. and Morgan, L.G., 1984, Respiratory cancer mortality of Welsh nickel refinery workers, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 37 - 46, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Prystowsky, S.D., Allen, A.M., Smith, R.W., Nonomura, J.H., Odom, R.B. and Akers, W.A., 1979, Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine, Arch. Dermatol., 115: 959–962.

    PubMed  CAS  Google Scholar 

  • Rahkonen, E., Junttila, M.L., Kalliomaki, P.L., Olkinouora, M., Koponen, M., and Kalliomaki, K., 1983, Evaluation of biological monitoring among stainless steel welders, Intern. Arch. Occup. Environ. Health, 52: 243–255.

    CAS  Google Scholar 

  • Raithel, H.J. and Schaller, K.H., 1981, Toxicity and carcinogenicity of nickel and its compounds. A review of the current status. Zbl. Bakt. Hyg., I. Abt. Prig. B., 173: 63–91.

    CAS  Google Scholar 

  • Raithel, H.J., Mayer, P., Schaller, K.H., Mohrmann, W., Welte, D. and Valentin, H., 1981, Untersuchungen zur Nickel-Exposition bei Beschaftigten in der Glas-Insustrie, Zbl. Arbeitsmed., 31: 332–339.

    CAS  Google Scholar 

  • Raithel, H.J., Schaller, K.H., Mohrmann, W., Mayer, P. and Henkels, U., 1982, Untersuchunger zur Ausscheidungskinetik von Nickel bei Beschaftigten in der Glas- und Galvanischen Industrie, in: “Bericht uber die 22 Jarestagung der Deutschen Gesellschaft fur Arbeitsmedizin. Komb. Belastungen Arbeitsplatz,” T.M. Fliedner, ed., pp. 223–228.

    Google Scholar 

  • Raithel, H.J., Kress, W., Schaller, K.H., Welte, D. and Valentin, H, 1985, Toxicological and occupational medical investigations concerning nickel-exposure in different industrial areas in the FRG, in: “Progess in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 219–222, Blackwell, Oxford.

    Google Scholar 

  • Rigaut, J.P., 1983, “Rapport Preparatorie sur les Criteres de Sante pour le Nickel,” (Health and Safety Directorate Document No. V/E/24/83), pp. 1–1009, Commission of the European Communities, Luxembourg.

    Google Scholar 

  • Roed-Petersen, B., Roed-Petersen, J, and Jorgensen, K.D., 1979, Nickel allergy and osteomyelitis in a patient with metal osteosynthesis of a jaw fracture, Contact Dermatitis, 5: 108–112.

    PubMed  CAS  Google Scholar 

  • Rooker, G.D. and Wilkinson, J.D., 1980, Metal sensitivity in patients undergoing hip replacement, J. Bone Joint Surgery, 62B: 502–505.

    Google Scholar 

  • Rubanyi, G., Ligeti, L., Koller, A. and Kovach, A.G.B., 1984, Possible role of nickel ions in the pathogenesis of ischemic coronary vasoconstriction in the dog heart, J. Mol. Cell. Cardiol., 16: 533–546.

    PubMed  CAS  Google Scholar 

  • Sarkar, B, 1984, Nickel metabolism, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 367–384, Intern. Agency Res. Cancer, Lyon,

    Google Scholar 

  • Schaller, K.H., Stoeppler, M. and Raithel, H.J., 1982, The analytical determination of nickel in biological matrices. A summary of present knowledge and experience, Staub Reinhalt. Luft, 42: 137–140.

    CAS  Google Scholar 

  • Schaller, K.H., Zober, A. and Valentin, H., iyöb, txternal and internal exposure of arc welders during one working week, in: “Progress in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 153–156, Blackwell, Oxford.

    Google Scholar 

  • Seemann, J., Wittig, P., Kollmeier, H. and Rothe, G., 1985, Analitische Bestimmung von Cd, Pb, Zn, Cr, and Ni in Humangeweben, Lab. Med., 9: 294–299.

    CAS  Google Scholar 

  • Smialowicz, R.J., Rogers, R.R., Riddle, M.M. and Stott, G.A., 1984, Immunologic effects of nickel: I. Suppression of cellular and humoral immunity, Environ. Res., 33: 413–427.

    PubMed  CAS  Google Scholar 

  • Smialowicz, R.J., Rogers, R.R., Riddle, M.M., Garner, R.J., Rowe, D.G. and Luebke, R.W., 1985, Immunological effects of nickel: II. Suppression of natural killer cell activity, Environ. Res., 36: 56–66.

    PubMed  CAS  Google Scholar 

  • Solomons, N.W., Viteri, F., Shyler, T.R. and Nielsen, F.H., 1982, Bioavailability of nickel in man: effects of foods and chemically- defined dietary constituents on the absorption of inorganic nickel, J. Nutr., 112: 39–50.

    PubMed  CAS  Google Scholar 

  • Stoeppler, M., 1980, Analysis of nickel in biological materials and natural waters, in: “Nickel in the Environment,” J.O. Nriagu, ed., pp. 661–822,ley, New York.

    Google Scholar 

  • Stoeppler, M., 1984, Analytical chemistry of nickel, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 459–468, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Sunderman, F.W., 1970, Nickel poisoning, in: “Laboratory Diagnosis of Disease Caused by Toxic Agents,” F.W. Sunderman and F.W. Sunderman, Jr., eds., pp. 387 - 396, Warren H. Green, Inc., St. Louis.

    Google Scholar 

  • Sunderman, F.W., 1971, The treatment of acute nickel carbonyl poisoning by sodium diethyldithiocarbamate, Ann. Clin. Res., 3: 182–185.

    PubMed  Google Scholar 

  • Sunderman, F.W., Jr., 1980, Analytical biochemistry of nickel, Pure Appl. Chem., 52: 527–544.

    Google Scholar 

  • Sunderman, F.W., Jr., 1983, Potential toxicity from nickel contamination of intravenous fluids, Ann. Clin. Lab. Sci., 13: 1–4.

    PubMed  CAS  Google Scholar 

  • Sunderman, F.W., Jr., 1984a, Nickel, in: “Hazardous Metals in Human Toxicology,” A. Vercruysse, ed., pp. 279–306, Elsevier, Amsterdam.

    Google Scholar 

  • Sunderman, F.W., Jr., 1984b, Recent progress in nickel carcinogenesis, Toxicol. Environ. Chem., 8: 235–252.

    CAS  Google Scholar 

  • Sunderman, F.W., Jr., 1984c, Carcinogenicity of nickel compounds in animals, in: “Nickel in the Human Environment,” F.W. Sunderman, Jr., ed., pp. 127 - 142, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Sunderman, F.W., Jr., 1986a, Biological effects of nickel and sources of nickel exposures, in: “IARC Monographs on Environmental Carcinogens - Selected Methods of Analysis,” Vol. 8, pp. 79–92, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Sunderman, F.W., Jr., 1986b, Nickel, in: “Handbook on Toxicity of Inorganic Compounds,” H.G. Seiler, and H. Sigel, eds., in press, Marcel Dekker, New York.

    Google Scholar 

  • Sunderman, F.W., Jr., 1986c, Kinetics and biotransformation of nickel and chromium, in: “Health Hazards and Biological Effects of Welding Fumes and Gases,” R.M. Stern, A. Berlin, A.C. Fletcher and J. Jarvisalo, eds., pp. 229–247, Elsevier, Amsterdam.

    Google Scholar 

  • Sunderman, F.W., Jr., 1986d, Nickel determination in body fluids, tissues, excreta, and water, in: “IARC Monographs on Environmental Carcinogens - Selected Methods of Analysis,” Vol. 8, pp. 319 - 334, Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Sunderman, F.W., Jr. and Fraser, C.B., 1983, Effects of nickel chloride and diethyldithiocarbamate on metallothionein in rat liver and kidney, Ann. Clin. Lab. Sci., 13: 489–495.

    PubMed  CAS  Google Scholar 

  • Sunderman, F.W., Jr. and Horak E., 1981, Biochemical indices of

    Google Scholar 

  • nephrotoxicity exemplified by studies of nickel nephropathy, in: “Organ-Directed Toxicity: Chemical Indices and Mechanisms,” S.S. Brown and D.S. Davies, eds., pp. 52–64, Pergamon, London.

    Google Scholar 

  • Sunderman, F.W., Jr., Roszel, N.O. and Clark, R.J., 1968, Gas

    Google Scholar 

  • chromatography of nickel carbonyl in blood and breath, Arch. Environ. Health, 16:836–843.

    Google Scholar 

  • Sunderman, F.W., Jr., Coulston, F., Eichhorn, G.I., Fellows, J.A., Mastromatteo, E., Reno, H.T. and Samitz, M.H., 1975, “Nickel,” pp. 1–277, National Academy of Sciences, Washington, D.C. Sunderman, F.W., Jr., Costa, E.R., Fraser, C., Hui, G., Levine, J.J. and Tse, T.P.H., 1981, 63Nickel-constituents in renal cytosol of rats after injection of 63nickel chloride, Ann. Clin. Lab. Sci., 11:488–496.

    Google Scholar 

  • Sunderman, F.W., Jr., Hopfer, S.M., Reid, M.C., Shen, S.K. and Kevorkian, C.B., 1982b, Erythropoietin-mediated erythrocytosis in rodents after intrarenal injection of nickel subsulfide, Yale J. Biol Med., 55: 123–136.

    PubMed  CAS  Google Scholar 

  • Sunderman, F.W., Jr., Reid, M.C., Shen, S.K. and Kevorkian, C.B., 1983a, Embryotoxicity and teratogenicity of nickel compounds, in: “Reproductive and Developmental Toxicity of Metals,” T.W. Clarkson, G.F. Nordberg and P.R. Sager, eds., pp. 399 - 416, Plenum, New York.

    Google Scholar 

  • Sunderman, F.W., Jr., Mangold, B.L., Wong, S.H.Y., Shen, S.K., Reid, M.C. and Jansson, I., 1983b, High performance size-exclusion chromatography of 63Ni-constituents in renal cytosol and microsomes from 63NiCl2-treated rats, Res. Commun. Chem. Pathol. Pharmacol., 39: 477–492.

    Google Scholar 

  • Sunderman, F.W., Jr., Reid, M.C. Bibeau, L.M. and Linden, J.V., 1983c, Nickel induction of microsomal heme oxygenase activity in rodents, Toxicol. Appl. Pharmacol., 68: 87–95.

    CAS  Google Scholar 

  • Sunderman, F.W., Jr., Aitio, A., Berlin, A., Bishop, C., Buringh, E., Davis, W., Gounar, M., Jacquingnon, P.C., Mastromatteo, E., Rigaut, J.P., Rosenfeld, C., Saracci, R. and Sors, A., eds., 1984a, “Nickel in the Human Environment,” Intern. Agency Res. Cancer, Lyon.

    Google Scholar 

  • Sunderman, F.W., Jr., Crisostomo, C., Reid, M.C., Hopfer, S.M. and Nomoto, S., 1984b, Rapid analysis of nickel in serum and whole blood by electrothermal atomic absorption spectrophotometry, Ann. Clin. Lab. Sci., 14: 232–241.

    PubMed  CAS  Google Scholar 

  • Sunderman, F.W., Jr., Marzouk, A., Crisostomo, M.C. and Weatherby, D.R., 1985a, Electrothermal atomic absorption spectrophotometry of nickel in tissue homogenates, Ann. Clin. Lab. Sci., 15: 299–307.

    PubMed  CAS  Google Scholar 

  • Sunderman, F.W., Jr., Marzouk, A., Hopfer, S.M., Zaharia, 0. and Reid, M.C., 1985b, Increased lipid peroxidation in tissues of nickel chloride-treated rats. Ann. Clin. Lab. Sci., 15: 229–236.

    CAS  Google Scholar 

  • Sunderman, F.W., Jr., Aitio, A., Morgan, L.G. and Norseth, T., 1986a, Biological monitoring of nickel, Toxicol. Industr. Health, in press.

    Google Scholar 

  • Sunderman, F.W., Jr., Hopfer, S.M., Crisostomo, M.C. and Stoeppler, M., 1986b, Rapid analysis of nickel in urine by electrothermal atomic absorption spectrophotometry, Ann. Clin. Lab. Sci., 16: 219–230.

    PubMed  CAS  Google Scholar 

  • Tandon, S.K., Mathur, A.K. and Gaur, J.S., 1977, Urinary excretion of chromium and nickel among electroplaters and pigment industry workers, Intern. Arch. Occup. Environ. Health, 40: 71–76.

    CAS  Google Scholar 

  • Templeton, D.M. and Sarkar, B., 1985, Peptide and carbohydrate complexes of nickel in human kidney, Biochem. J., 230: 35–42.

    PubMed  CAS  Google Scholar 

  • Thomson, A.J., 1982, Proteins containing nickel, Nature, 298: 602–603.

    PubMed  CAS  Google Scholar 

  • Tola, S., Kilpio, J. and Virtamo, M., 1979, Urinary and plasma concentrations of nickel as indicators of exposure to nickel in an electroplating shop, J. Occup. Med., 21: 184–188.

    PubMed  CAS  Google Scholar 

  • Torjussen, W. and Andersen, I., 1979, Nickel concentrations in nasal mucosa, plasma, and urine in active and retired nickel workers, Ann. Clin. Lab. Sci., 9: 289–298.

    PubMed  CAS  Google Scholar 

  • Tossavainen, A., Nurminer, M., Mutanen, P. and Tola, S., 1980, Application of mathematical modeling for assessing the biological half-times of chromium and nickel in field studies, Brit. J. Indust. Med., 37: 285–291.

    CAS  Google Scholar 

  • Tossavainen, A., Nurminer, M., Mutanen, P. and Tola, S., 1980, Application of mathematical modeling for assessing the biological half-times of chromium and nickel in field studies, Brit. J. Indust. Med., 37:285-291.

    Google Scholar 

  • Voss, R., Reith, A. and Reichborn-Kjennerud, S., 1985, Cytology as a screening method in the detection of precancerous nasal mucosal changes in nickel workers, in: “Progress in Nickel Toxicology,” S.S. Brown and F.W. Sunderman, Jr., eds., pp. 173–176, Blackwell, Oxford.

    Google Scholar 

  • Vuopala, U., Huhti, E., Takkunen, J. and Huikko, M., 1970, Nickel carbonyl poisoning: report of 25 cases, Ann. Clin. Res., 2: 214–222.

    PubMed  CAS  Google Scholar 

  • Webster, J.D., Parker, T.F., Alfrey, A.C., Symthe, W.R, Kubo, H., Neal, G., and Hull, A.R., 1980, Acute nickel intoxication by dialysis, Ann. Intern. Med., 92: 631–633.

    PubMed  CAS  Google Scholar 

  • Williams, S.J., Holden, K.M., Sorbransky, M. and Menzel, D.B., 1980, The distributional kinetics of Ni2+ in the rat lung, Toxicol. Appl. Pharmacol., 55: 85–93.

    PubMed  CAS  Google Scholar 

  • Wills, M.R., Brown, C.S., Bertholf R.L., Ross, R. and Savory, J., 1985, Serum and lymphocyte, aluminum and nickel in chronic renal failure, Clin. Chim. Acta, 145: 193–196.

    PubMed  CAS  Google Scholar 

  • Zober, A., Kick, K., Schaller, K.H., Schellman, B,, and Valentin, H., 1984a, “Normal values” of chromium and nickel in human lung, kidney, blood and urine samples, Zbl. Bakt. Hyg. I. Abt. Prig. B., 179: 80–95.

    Google Scholar 

  • Zober, A., Welte, D. and Schaller, K.H., 1984b, Untersuchungen zur Kinetik von Chrom and Nickel in biologischen Material wahrend einwochign Lichtbogenschweissens mit Chrom-Nickel-haltigen Zusatzwerkstoffen, Schweissen Schneiden, 10: 461–464.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, 06032, USA

    F. William Sunderman Jr.

  2. Department of Pharmacology, University of Connecticut School of Medicine, Farmington, Connecticut, 06032, USA

    F. William Sunderman Jr.

Authors
  1. F. William Sunderman Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Rochester Shool of Medicine, Rochester, New York, USA

    Thomas W. Clarkson

  2. The Karolinska Institute, Stockholm, Sweden

    Lars Friberg

  3. University of Umea, Umea, Sweden

    Gunnar F. Nordberg

  4. Stauffer Chemical Company, Farmington, Connecticut, USA

    Polly R. Sager

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Sunderman, F.W. (1988). Nickel. In: Clarkson, T.W., Friberg, L., Nordberg, G.F., Sager, P.R. (eds) Biological Monitoring of Toxic Metals. Rochester Series on Environmental Toxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0961-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0961-1_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-42809-8

  • Online ISBN: 978-1-4613-0961-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation