Abstract
While the decrease in brain serotonin (5-HT) is well known to enhance sexual activity in the male rat (e.g., Tagliamonte et al., 1969), the administration of antiserotonergic agents to female rats caused contradictory results (e.g., Segal and Whalen, 1970; Zemlan et al., 1973; Emery and Moss, 1984). Previous results by our laboratory (Moja et al., 1989) showed that the acute administration of an amino acid mixture lacking tryptophan (TRY) causes a 40% depletion in whole brain 5-HT. This is because the TRY-free amino acid mixture will induce new protein synthesis, and endogenous blood and brain TRY is incorporated into proteins (Moja et al., 1991).
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References
Benedetti F. and Moja E.A. 1993 Failure of a to han-free amino acid mixture to modify sexual behavior in the female ratPhysiol. Behav. 54: 1235.
Carruba M.O. Picotti G.B. Genovese E. and Mantegazza P. 1977. Stimulatory effect of a maize diet on sexual behavior of male rats.Lie Sci. 20: 159.
Emery, D.E., and Moss, R.L., 1984. P-cholorophenylalanine alters pacing of opulation in female rats.Pharmacol. Biochem. Behav.20: 337.
Fratta, W., Biggio, G., and Gessa, G.L.,1977. Homosexual mounting behavior induced in male rats and rabbits by a tryptophan-free diet.Lie Sci. 21:379
Ginton, A., 1975. Copulation in noncopulators: effect of PCPA in male rats.Pharmacol. Biochem. Behav.4: 357.
Hlinak, Z., and Madlafousek, J., 1981. Estradiol treatment and Precopulatory behavior in ovariectomized female rats. Physiol. Behav. 26: 171.
Moja, E.A., Cipolla, P, Castoldi, D., and Tofanetti, O., 1989. Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats.Life Sci. 44: 971.
Moja, E.A., Restani, P, Corsini, E., Stacchezzini, M.C., Assereto, R., and Galli, C.L., 1991. cycloheximide blocks the fall of plasma and tissue tryptophan levels after tryptophan-free amino acid mixtures.Life Sci.49:1121
Segal, D.S, and Whalen, R.E., 1970. Effect of chronic administration of p-chlorophenylalanine on sexual receptivity of the female rat.Psychoharmacologia16: 434.
Tagliamonte, A., Tagliamonte, E., Gessa, G.L., and Brodie, B.B., 1969. Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats.Science166: 1433
Tagliamonte A., Tagliamonte, P., and Gessa, G.L., 1971. Reversal of pargyline-induced inhibition of sexual behavior in male rats by parachlorophenylalanine.Nature230: 244.
Zemlan F.P. Ward I.L. Crowle W.R. and Margules, D.L.,1973. Activation of lordotic responses in female rats by suppression of serotonergic activity.Science179:1010
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© 1996 Plenum Press, New York
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Moja, E.A., Benedetti, F. (1996). Sexual Behavior in Male and Female Rats after a Tryptophan-Free Amino Acid Mixture. In: Filippini, G.A., Costa, C.V.L., Bertazzo, A. (eds) Recent Advances in Tryptophan Research. Advances in Experimental Medicine and Biology, vol 398. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0381-7_12
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DOI: https://doi.org/10.1007/978-1-4613-0381-7_12
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