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Estrogen Modulation of Blood Copper and Other Essential Metal Concentrations

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Inflammatory Diseases and Copper

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 2))

Abstract

The modulation of serum copper/ iron and zinc by estrogens during pregnancy and oral contraceptive usage has long been described. The current understanding is that serum copper or ceruloplasmin is elevated almost 100% above control values, whereas serum iron and zinc are slightly depressed from control levels. The effect of estrogen on serum copper does not appear to correlate well with either serum or urinary estrogen levels, suggesting a secondary relationship. One mechanism for elevated serum copper involves a polypeptide produced by monocytes described in infectious disease, leukocyte endogenous mediators (LEM). Since estrogens stimulate monocyte populations and a number of features of estrogen effects are similar to LEM actions, we hypothesize that estrogens modulate serum copper (ceruloplasmin) through monocyte release of LEM and its actions.

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Author information

Authors and Affiliations

  1. Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, Ohio, 44106, USA

    Arthur Flynn

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  1. Arthur Flynn
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Editor information

Editors and Affiliations

  1. Department of Biopharmaceutical Sciences, College of Pharmacy and Department of Pharmacology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA

    John R. J. Sorenson

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© 1982 The Humana Press Inc.

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Flynn, A. (1982). Estrogen Modulation of Blood Copper and Other Essential Metal Concentrations. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_3

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  • DOI: https://doi.org/10.1007/978-1-4612-5829-2_3

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5831-5

  • Online ISBN: 978-1-4612-5829-2

  • eBook Packages: Springer Book Archive

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