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Cu-Zn Superoxide Dismutase

  • Chapter
Inflammatory Diseases and Copper

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 2))

Abstract

Three distinct types of superoxide dismutase are known, each differing with respect to the metal at the active site (1). SOD (superoxide oxidoreductase, EC 1.15.1.1) is believed to be present in all oxygen metabolizing cells. Each type is distinguished by its amino acid sequence and each contains different prosthetic metals, Cu, Zn-, Fe-, and Mn-enzyme (2-5). This enzyme catalyzes the reaction

$${O_{\tilde \dot 2}} + {O_{\tilde \dot 2}} + 2{H^ + } \to {H_2}{O_2} + {O_2}$$
([1])

(6). There is considerable evidence that this enzyme is absolutely necessary for the survival of all oxygen-metabolizing cells (1).

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Authors and Affiliations

  1. Wabash College, Crawfordsville, IN, 47933, USA

    Garry R. Buettner

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  1. Garry R. Buettner
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Editors and Affiliations

  1. Department of Biopharmaceutical Sciences, College of Pharmacy and Department of Pharmacology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, USA

    John R. J. Sorenson

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© 1982 The Humana Press Inc.

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Buettner, G.R. (1982). Cu-Zn Superoxide Dismutase. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_19

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  • DOI: https://doi.org/10.1007/978-1-4612-5829-2_19

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-5831-5

  • Online ISBN: 978-1-4612-5829-2

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