Abstract
The presence of Cu in animal tissues was recognized during the 19th century, but its essentiality as a nutrient in the diet of mammals was not reported until 1928 by Hart and his associates1. The importance of Cu in prenatal development was recognized from studies on the disease “enzootic ataxia” in newborn lambs. This disorder is characterized by spastic paralysis, incoordination of movement, probably due to reduced myelination of the CNS, and anemia. Affected animals usually die within a short time after birth2. Copper supplementation of the ewe during pregnancy prevented the disorder.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E. B. Hart, H. Steenbock, and C. A. Elvehjem, J. Biol. Chem., 77, 797 (1928).
L. S. Hurley, and C. L. Keen in “Copper in the Enviroment, Part II Health Effects”. J. O. Nriagu, Ed., John Wiley & Sons, 1979, p. 33 ff.
H. W. Bennetts, and A. B. Beck, Aust. Coun. Sci. Ind. Res. Bull., 147, 1 (1942).
J. R. Prohaska, and W. W. Wells, J. Neurochem., 25, 221 (1975).
L. S. Hurley, Physiol. Reviews, 61, 249 (1981).
R. B. Rucker, and D. Tinker, Int. Rev. Exp. Pathol., 17, 1 (1977).
B. L. O’Dell, B. C. Hardwick, and G. Reynolds, J. Nutr., 73, 151 (1961).
M. S. Morton, P. C. Elwood, and M. Abernethy, Br. J. Prev. Soc. Med., 30, 36 (1976).
N. Wald, and M. Hambidge, Lancet, ii, 560 (1977).
G. Wiener, Livestock Production Science, 6, 223 (1979).
L. S. Hurley, C. L. Keen, and B. Lönnerdal in “Biological Roles of Copper”, Ciba Foundation, 79, p. 227.
J. R. Prohaska, Life Sci., 26, 731 (1980).
J. H. Menkes, M. Azter, G. K. Steigleden, D. R. Weakly, and J. H. Sung, Pediatrics, 29, 764 (1962).
D. K. Mjølnerød, S. A. Dommerud, K. Rasmussen, and S. T. Gjeruldsen, Lancet, i, 673 (1971).
L. Solomon, G. Abrams, M. Dinner, and L. Berman, N. Engl. J. Med., 196, 54 (1977).
C. L. Keen, P. Mark-Savage, B. Lonnerdal, and L. S. Hurley, Teratology, 23, 44A (1981).
P. Mark-Savage, B. Lönnerdal, and L. S. Hurley, Teratology, 23, 50A (1981).
B. L. Lönnerdal, C. L. Keen, and L. S. Hurley, Ann. Rev. Nutr., 1, 149 (1981).
N. M. Runner, and J. R. Miller, Anat. Rec., 124, 437 (1956).
V. H. Ferm, and D. P. Hanlon, Biol. Reprod., 11, 97 (1975).
M. Marois, and M. Bouvet, C. R. Seances Soc. Biol. (Paris), 166, 1237 (1972).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 The Humana Press Inc.
About this chapter
Cite this chapter
Keen, C.L., Lönnerdal, B., Hurley, L.S. (1982). Teratogenic Effects of Copper Deficiency and Excess. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_11
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5829-2_11
Publisher Name: Humana Press
Print ISBN: 978-1-4612-5831-5
Online ISBN: 978-1-4612-5829-2
eBook Packages: Springer Book Archive