Abstract
“For over the past quarter of a century, no field of science has made more spectacular strides than cell biology. And over the balance of the century, no other field of science offers greater promise to increase our understanding of life and our ability to deliver quality health care.” With these words Senator Edward Kennedy opened a symposium entitled “The Biological Revolution: Applications Cell Biology to Public Welfare” held at the First International Conference on Cell Biology in 1976.1 The symposium included a number of conferences on the application of recent advances in cell biology to current medical and environmental issues. The areas that were covered included cancer, biology of reproduction, behavior, DNA recombination and genetic disease, and environmental carcinogens, but the contributions of cell biology to the study of parasitic diseases were not mentioned. In this paper I will review some of the most important findings concerning the cell biology of parasitism, as well as speculate on future perspectives.
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References
Kennedy EM (1979) Biomedical science in an expectant society. In: Weissmann G (ed) The biological revolution. Applications of cell biology to public welfare. Plenum Press, New York, pp 11-19
Palade GE (1975) Intracellular aspects of the process of protein synthesis. Science 189: 347–358
Palade GE (1971) Albert Claude and the beginnings of biological electron microscopy. Cell Biol 50: 5D–19D
Palade GE (1977) Greetings to the I International Congress on Cell Biology. In: Brinkley DR, Porter KR (eds) International cell biology. 1976-1977. Rockefelller University Press, New York, pp vii-x
Bartnicki-Garcia S (1981) Role of chitosomes in the synthesis of fungal cell walls. In: Schlessinger D (ed) Microbiology-1981. American Society for Microbiology, Washington DC, pp 238-244
Tomlinson G, Jones EA (1962) Isolation of cellulose from the cyst wall of a soil amoeba. Biochim Biophys Acta 63:194–200
Arroyo-Begovich A, Cárabez-Trejo A, Ruiz-Herrera J (1980) Identification of the structural components in the cyst wall of Entamoeba invadens. J Parasitol 66: 735–741
Wharton D (1980) Nematode egg-shells. Parasitology 81: 447–463
Bird AF (1980) The nematode cuticle and its surface. In: Nematodes as biological models. Academic Press, New York, pp 213-236
.Martinez-Palomo A (1978) Ultrastructural characterization of the cuticle of Onchocerca volvulus microfilaria. J Parasitol 64: 128–136
.De Souza W, Argäello C, Martinez-Palomo A, Trissl D, Gonzdlez-Rubles A, Chiara E (1977) Surface charge of Trypanosoma cruzi: Binding of cationized ferritin and measurement of electrophoretic mobility. J Protozool 24: 411–415
De Souza W, Martinez-Palomo A, Gonzalez-Robles A (1978) The cell surface of Trypanosoma cruzi: Cytochemistry and freeze-fracture. J Cell Sci 33: 285–289
Gutteridge WE (1981) Trypanosoma cruzi: Recent biochemical advances. Transactions of the Royal Society of Tropical Medicine and Hygiene 75: 484–492
.Colli W, Andrews NW, Zingales B (1981) Surface determinants in American trypanosomes. In: Schweiger HG (ed) International cell biology 1980-1981. Springer-Verlag, Berlin, pp 401-410
Miles MA, Povoa MM, Prata A, Cedillos RA, De Souza AA, Macedo V (1981) Do radically dissimilar Trypanosoma cruzi strains (zymodemes) cause Venezuelan and Brazilian forms of Chagase disease? Lancet1: 1338–1340
Rosario V (1981) Cloning of naturally occuring mixed infections of malaria parasites. Science 212: 1037–1038
Sargeaunt PG, Williams JE, Grene JD (1978) The differentiation of invasive and non-invasive Entamoeba bistolytica by isoenzyme electrophoresis. Trans R Soc Trop Med Hyg 72: 519–521
Pfefferkorn ER, Schwartzman JD (1981) Use of mutants to study the biochemistry of the host-parasite relationship in cultured cells infected with Toxoplasma gondi. In: Schweiger HG (ed) International cell biology 1980-1981. Springer-Verlag, Berlin, pp 411-420
Pfefferkorn LC, Pfefferfrom ER (1980) Toxoplasma gondii: Genetic recombination between drug resistant mutants. Exp Parasitol 50: 305–316
Parsons CL, Stauffer Ch, Schmidt JD (1980) Bladder-surface glycosaminoglycans: An efficient mechanism of environmental adaptation. Science 208: 605–607
Owen RL (1977) Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer“s patches in the normal unobstructed mouse intestine: An ultrastructural study. Gastroenterology 72: 440–451
Keren DF (1980) Immunology and immunopathology of the gastrointestinal tract. American Society of Clinical Pathologists, Chicago
Mora-Galindo J, Martinez-Paloma A, Gonzalez-Robles A (1983) Interacci6n entry Entamoeba bistolytica y epitelio cecal del cobayo. Arch Invest Med (Mex) 13 (suppl 3): 223-243
Synderman R, Goetzl EJ (1981) Molecular and cellular mechanisms of leukocyte chemotaxis. Science 213: 830–837
Davis JM, Gallin JI (1981) The neutrophil. In: Oppenhiem jj, Rosentreich DL, Potter D (eds) Cellular functions in immunity and inflammation. Edward Arnold, London, pp 77-102
Butterworth AE, David JR (1981) Eosinophil function. N Engl J Med 304:154–156
Jones TC (1981) Interactions between murine macrophages and obligate intracellular protozoa. Am J Pathol 102: 127–132
Nogueira N, Cohn Z (1976) Trypanosoma cruzi: Mechanism of entry and intracellular fate in mammalian cells. J Exp Med 143: 1402–1420
.Jones TC, Hirsch JG (1972) The interaction of Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. J Exp Med 136: p1173-1194
Chang PK Dwyer DM (1976) Multiplication of a human parasite (Leishmania donovani) in phagolysosomes of hamster macrophages in vitro. Science 193: 678–680
Aikawa M, Miller LW, Rabbege JH, Epstein N (1981) Freeze-fracture study on the erythrocyte membrane during malarial parasite invasion. Cell Biol 91: 55–62
Munoz ML, Calderon J, Rojkind M (1982) The collagenase of Entamoeba histolytica. J Exp Med 155: 42–51
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Martínez-Palomo, A. (1983). Cell Biology and the Future Parasitology. In: Warren, K.S., Bowers, J.Z. (eds) Parasitology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5550-5_19
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DOI: https://doi.org/10.1007/978-1-4612-5550-5_19
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