Summary
The isolated red cell ghost was used as a biomembrane model to investigate the influence of aminoglycosides upon phosphoinositide metabolism by measuring 32P incorporation into the polyphosphoinositides (PIP and PI P2). A rapid and dose-dependent decrease in [32P]PIP2 and an increase in [32P]PIP were observed. Studies with neomycin revealed that these changes could likely be ascribed to an inhibition of the PIP-kinase activity by the drug. The order of potency of various aminoglycosides for the impairment of phosphoinositide metabolism varied as a function of the cationicity of the drugs. A possible relationship between the aminoglycoside-induced nephrotoxicity and the drug-induced alteration of phosphoinositide turnover is discussed.
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Marche, P., Girard, A., Koutouzov, S. (1985). Drug-Induced Modifications of Phosphoinositide Metabolism. In: Bleasdale, J.E., Eichberg, J., Hauser, G. (eds) Inositol and Phosphoinositides. Experimental Biology and Medicine, vol 6. Humana Press. https://doi.org/10.1007/978-1-4612-5184-2_14
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DOI: https://doi.org/10.1007/978-1-4612-5184-2_14
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