Abstract
One of the most dramatic advances in recent years has been the development of several new pulse sequences, made possible by the advent of dedicated microcomputers, which have allowed precise manipulations of pulse angles, introduction of delays between pulses, and rapid Fourier transformations. These have heralded the advent of a number of extremely powerful procedures among which may be mentioned: (a) new pulse sequences for the unambiguous assignments of methyl, methylene, methine, and quaternary carbon atoms, side—stepping the difficulties associated with the overlapping of multiplets in the normal off—resonances measurements. Examples are APT, DEPT, ADEPT, etc.; (b) two—dimensional NMR spectroscopy for observing couplings between protons, between protons and carbon atoms, and more recently between carbon atoms themselves; and (c) precise measurements of nuclear Overhauser enhancements by NOE difference measurements involving alternate recording of normal and NOE enhanced spectra, and automatic computer—assisted subtractions which result in measurements of even small enhancements, which were previously not possible.
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G.C. Levy, Topics in Carbon-13 NMR Spectroscopy, Wiley-Interscience, New York (1984).
J.W. Cooper, Spectroscopic Techniques for Organic Chemists, John Wiley and Sons, New York (1980).
D.Shaw, Pulsed Fourier Transform NMR Spectroscopy, Elsevier Scientific Publishing Co., Amsterdam (1979).
F.W. Wehrli and T. Wirthlin, Interpretation of Carbon-13 NMR Spectra, Heyden and Son Ltd, London (1978).
E. Breitmaier and W. Voelter, 13 C-NMR Spectroscopy, Verlag Chemie, Weinheim (1978).
C. Brevard and P. Granger, Handbook of High Resolution Multinuclear NMR, John Wiley and Sons. New York (1981).
G.C. Levy, R.L. Lichter, and G.L. Nelson, Carbon-13 Nuclear Magnetic Resonance Spectroscopy, John Wiley and Sons, New York (1980).
H. Günther, NMR Spectroscopy, John Wiley and Sons, New York (1980).
W.P. Aue, E. Bartholdi, and R.R. Ernst, Two—dimensional spectroscopy. Application to nuclear magnetic resonance, J. Chem. Phys. 64, 2229 (1976).
G. Bodenhausen, R. Freeman, and D.L. Turner, Suppression of artifacts in two—dimensional J spectroscopy, J. Magn. Resonance 27, 511 (1977).
G. Bodenhausen, R. Freeman, G.A. Morris, R. Niedermeyer, and D.L. Turner, A simple approach to single—channel quadrature detection, J. Magn. Resonance 25, 559 (1977).
P. Bachmann, W.P. Aue, L. Muller, and R.R. Ernst, Phase separation in two- dimensional spectroscopy, J. Magn. Resonance 28, 29 (1977).
W.P. Aue, P. Bachmann, A. Wokaun, and R.R. Ernst, Sensitivity of two—dimensional NMR spectroscopy, J. Magn. Resonance 29, 523 (1978).
A. Kumar, Two—dimensional spin—echo NMR spectroscopy: a general method for calculation of spectra, J. Magn. Resonance 30, 227 (1978).
L. Muller and R.R. Ernst, Coherence transfer: Heteronuclear 2-D NMR spectra, Mol. Phys. 38, 963 (1979).
M.H. Levitt and R. Freeman, Phase adjustment of two—dimensional NMR spectra, J. Magn. Resonance 34, 675 (1979).
G. Bodenhausen, S.P. Kempsell, and R. Freeman, Spinning sidebands in two—dimensional spin—echo spectra, J. Magn. Resonance 35, 337 (1979).
A. Bax, A.F. Mehlkopf, and J. Smidt, A fast method for obtaining 2D J-resolved absorption spectra, J. Magn. Resonance 40, 213 (1980).
L.D. Hall and S. Sukumar, A versatile strategy for the generalized acquisition of proton spin—echo data: measurement of partially relaxed two—dimensional J spectra, J. Magn. Resonance 40, 405 (1980).
G. Bodenhausen and D.L. Turner, Artifacts in two—dimensional J spectra, J. Magn. Resonance 41, 200 (1980).
S. Brownstein, Slicing and projection in 2-D arrays, J. Magn. Resonance 42, 150 (1981).
R.L. Void and R.R. Void, Separation of single quantum spin echoes by two—dimensional Fourier transform techniques, J. Magn. Resonance 42, 173 (1981).
R. Freeman and J. Keeler, Suppression of artifacts in two—dimensional J spectra, J. Magn. Resonance 43, 484 (1981).
D.L. Turner, The measurement of coupling constants from two—dimensional NMR spectra, J. Magn. Resonance 39, 391 (1980).
A.D. Bain, A superspin analysis of two—dimensional FT NMR experiments, J. Magn. Resonance 39, 335 (1980).
A. Bax, R. Freeman, and G.A. Morris, A simple method for suppressing dispersion—mode contributions in NMR spectra: the “pseudo echo”, J. Magn. Resonance 43, 333 (1981).
D.L. Turner, Two—dimensional spin-echo spectroscopy of oriented systems, J. Magn. Resonance 46, 213 (1982).
W.P. Aue, J. Karhan, and R.R. Ernst, Homonuclear broad band decoupling and two—dimensional J-resolved NMR spectroscopy, J. Chem. Phys. 64, 4226 (1976).
G. Bodenhausen, R. Freeman, G.A. Morris and D.L. Turner, A simple pulse sequence for selective excitation in Fourier transform NMR, J. Magn. Resonance 31, 75 (1978).
K. Nagayama, P. Bachmann, K. Wuthrich, and R.R. Ernst, The use of cross—sections and of projections in two—dimensional NMR spectroscopy, J. Magn. Resonance 31, 133 (1978).
A. Bax, A.F. Mehlkopf, and J. Smidt, Homonuclear broad band—decoupled absorption spectra, with linewidths which are independent of the transverse relaxation rate, J. Magn. Resonance 35, 167 (1979).
K. Nagayama, A. Kumar, K. Wuthrich, and R.R. Ernst, Experimental techniques of two—dimensional correlated spectroscopy, J. Magn. Resonance 40, 321 (1980).
M.S. Broido and D.R. Kearns, Proton NMR evidence for an unusual conformation of poly C in solution, J. Magn. Resonance 41, 496 (1980).
G. Wider, R. Baumann, K. Nagayama, R.R. Ernst, and K. Wuthrich, Strong spin—spin coupling in the two—dimensional J-resolved 360-MHz proton NMR spectra of the common amino acids, J. Magn. Resonance 42, 73 (1981).
K. Nagayama and K. Wuthrich, Systematic application of two—dimensional proton nuclear magnetic resonance techniques for studies of proteins. 1. Combined use of spin—echo correlated spectroscopy and J-resolved spectroscopy for the identification of complete spin systems of non-labile protons in amino acid residues, Eur. J. Biochem. 114, 365 (1981).
G. Wagner, A. Kumar, and K. Wuthrich, Systematic application of two—dimensional proton nuclear magnetic resonance techniques for studies of proteins. 2. Combined use of correlated spectroscopy and nuclear Overhauser spectroscopy for sequential assignments of backbone resonances and elucidation of polypeptide secondary structures, Eur. J. Biochem. 114, 375 (1981).
C. Bosch, A. Kumar, R. Baumann, R.R. Ernst, and K. Wuthrich, 1-D and 2-D NOE in proteins, J. Magn. Resonance 42, 159 (1981).
A. Bax, R. Freeman, and G. Morris, Correlation of proton chemical shifts by two—dimensional Fourier transform NMR, J. Magn. Resonance 42, 164 (1981).
M. Ohuchi, M. Hosono, K. Matushita, and M. Imanari, A new pulse sequence in two—dimensional FT NMR. Solvent elimination using a Hahn echo, J. Magn. Resonance 43, 499 (1981).
A. Kumar, R.R. Ernst, and K. Wuthrich, A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton—proton cross—relaxation networks in biological macromolecules, Biochem. Biophys. Res. Commun. 95, 1 (1980).
A. Kumar, G. Wagner, R.R. Ernst, and K. Wuthrich, Studies of J-connectivities and selective proton—proton Overhauser effects in aqueous solutions of biological macromolecules by two—dimensional NMR experiments, Biochem. Biophys. Res. Commun. 96, 1156 (1980).
J. Jenner, B.H. Meier, P. Bachmann, and R.R. Ernst, 2-D NOE, J. Chem. Phys. 71, 4546 (1979).
B.H. Meier and R.R. Ernst, Elucidation of chemical exchange networks by two—dimensional NMR spectroscopy: the heptamethylbenzenonium ion, J. Am. Chem. Soc. 101, 6441 (1979).
S. Macura and R.R. Ernst, Elucidation of cross relaxation in liquids by two—dimensional NMR spectroscopy, Mol. Phys. 41, 95 (1980).
S. Macura, Y. Huang, D. Suter, and R.R. Ernst, Two—dimensional chemical exchange and cross—relaxation spectroscopy of coupled nuclear spins, J. Magn. Resonance 43, 259 (1981).
A. Bax and R. Freeman, COSY, COSY-45, F1 decoupling, J. Magn. Resonance 44, 542 (1981).
R. Baumann, G. Wider, R.R. Ernst, and K. Wuthrich, Improvement of 2D NOE and 2D correlated spectra by symmetrization, J. Magn. Resonance 44, 402 (1981).
G. Bodenhausen and R.R. Ernst, The accordion experiment, a simple approach to three—dimensional NMR spectroscopy, J. Magn. Resonance 45, 367 (1981).
R. Baumann, A. Kumar, R.R. Ernst and K. Wuthrich, Improvement of 2D NOE and 2D correlated spectra by triangular multiplication, J. Magn. Resonance 44, 76 (1981).
S. Macura, K. Wuthrich, and R.R. Ernst, Separation and suppression of coherent transfer effects in two-dimensional NOE and chemical exchange spectroscopy, J. Magn. Resonance 46, 269 (1982).
L. Muller, A. Kumar, and R.R. Ernst, Two—dimensional carbon-13 NMR spectroscopy, J. Chem. Phys. 63, 5490 (1975).
G. Bodenhausen, R. Freeman, and D.L. Turner, Two—dimensional J spectroscopy: Proton—coupled carbon-13 NMR, J. Chem. Phys. 65, 839 (1976).
G. Bodenhausen, R. Freeman, R. Niedermeyer, and D.L. Turner, High—resolution NMR in inhomogeneous magnetic fields, J. Magn. Resonance 24, 291 (1976).
R. Freeman, G.A. Morris, and D.L. Turner, Proton—coupled carbon-13 J spectra in the presence of strong coupling, I, J. Magn. Resonance 26, 373 (1977).
G. Bodenhausen, R. Freeman, G.A. Morris, and D.L. Turner, Proton—coupled carbon-13 J spectra in the presence of strong coupling, II, J. Magn. Resonance 28, 17 (1977).
A.A. Maudsley and R.R. Ernst, Indirect detection of magnetic resonance by heteronuclear two—dimensional spectroscopy, I, Chem. Phys. Lett. 50, 368 (1977).
D.L. Turner and R. Freeman, The proton—coupled carbon-13 spectrum of cholesterol, J. Magn. Resonance 29, 587 (1978).
R. Freeman and G.A. Morris, Experimental chemical shift correlation maps in nuclear magnetic resonance spectroscopy, J. Chem. Soc., Chem. Commun., 684 (1978).
G. Bodenhausen and R. Freeman, Correlation of chemical shifts of protons and carbon-13, J. Am. Chem. Soc. 100, 320 (1978).
A. Hohener, L. Muller, and R.R. Ernst, 13C 2-D in liquid crystals, Mol. Phys. 38, 909 (1979).
P.H. Bolton and G. Bodenhausen, Heteronuclear two—dimensional NMR as a conformational probe of cellular phosphates, J. Am. Chem. Soc. 101, 1080 (1979).
R. Freeman, S.P. Kempsell, and M.H. Levitt, Elimination of dispersion—mode contributions from two-dimensional NMR spectra, J. Magn. Resonance 34, 663 (1979).
L.D. Hall, G.A. Morris, and S. Sukumar, Resolution and assignment of the 270-MHz proton spectrum of cellobiose by homo- and heteronuclear two—dimensional NMR, J. Am. Chem. Soc. 102, 1745 (1980).
G. Bodenhausen, Heteronuclear J spectroscopy, J. Magn. Resonance 39, 175 (1980).
L.D. Hall and G.A. Morris, Measurement of carbon-13 proton coupling constants in oligosaccharides by two-dimensional carbon-13 NMR spectroscopy, Carbohyd. Res. 82, 175 (1980).
A.A. Maudsley, L. Muller, and R.R. Ernst, Cross—correlation of spin—decoupled NMR spectra by heteronuclear two—dimensional spectroscopy, J. Magn. Resonance 28, 463 (1977).
G. Bodenhausen and R. Freeman, Correlation of proton and carbon-13 NMR spectra by heteronuclear two—dimensional spectroscopy, J. Magn. Resonance 28, 471 (1977).
R. Niedermeyer and R. Freeman, Carbon—carbon spin—spin coupling studied by two—dimensional Fourier transformation, J. Magn. Resonance 30, 617 (1978).
L. Muller, High—sensitivity in 13C 2-D NMR, J. Magn. Resonance 36, 301 (1979).
L. Muller, Off—resonance decoupling in 13C 2-D NMR, J. Magn. Resonance 38, 79 (1980).
A.G. Avent and R. Freeman, NMR spin—lattice relaxation studied by magnetization transfer, J. Magn. Resonance 39, 169 (1980).
G. Bodenhausen and P.H. Bolton, Elimination of flip—angle effects in two—dimensional NMR spectroscopy. Application to cyclic nucleotides, J. Magn. Resonance 39, 339 (1980).
M.H. Levitt and R. Freeman, Simplification of NMR spectra by masking in a second frequency dimension, J. Magn. Resonance 39, 533 (1980).
A. Bax and G.A. Morris, An improved method for heteronuclear chemical shift correlation by two—dimensional NMR, J. Magn. Resonance 42, 501 (1981).
D.M. Thomas, M.R. Bendall, D.T. Pegg, D.M. Doddrell, and J. Field, Two—dimensional carbon-13-proton polarization transfer J spectroscopy, J. Magn. Resonance 42, 298 (1981).
G.A. Morris, Indirect two—dimensional J spectroscopy: measurement of proton multiplet structure via carbon-13 signals, J. Magn. Resonance 44, 277 (1981).
P.H. Bolton, Investigation of phospherine and cytidine 5’-phosphate by heteronuclear two—dimensional spectroscopy: samples with strong proton coupling, J. Magn. Resonance 45, 539 (1981).
A. Bax and R. Freeman, Relative signs of couplings, 1H-13C 2-D, J. Magn. Resonance 45, 177 (1981).
P.H. Bolton and G. Bodenhausen, Resolution enhancement, coherence transfer echoes. J. Magn. Resonance 46, 306 (1982).
M.R. Bendall, D.T. Pegg, D.M. Doddrell, and D.M. Thomas, A superior pulse sequence for two—dimensional chemical shift correlation spectroscopy, J. Magn. Resonance 46, 43 (1982).
P.H. Bolton and G. Bodenhausen, Double resonance in heteronuclear two—dimensional spectroscopy, J. Magn. Resonance 43, 339 (1981).
S. Vega and A. Pines, Operator formalism for double quantum NMR, J. Chem. Phys. 66, 5624 (1977).
A. Wokaun and R.R. Ernst, Selective detection of multiple quantum transitions in NMR by two—dimensional spectroscopy, Phys. Lett. 52, 407 (1977).
L. Muller, Detection of weak nuclei via MQ coherence, J. Am. Chem. Soc. 101, 4481 (1979).
A. Bax, R. Freeman, and S.P. Kempsell, Natural abundance carbon-13-carbon- 13 coupling observed via double—quantum coherence, J. Am. Chem. Soc. 102, 4849 (1980).
G. Bodenhausen, R.L. Void, and R. R. Void, Multiple quantum spin—echo spectroscopy, J. Magn. Resonance 37, 93 (1980).
A. Minoretti, W.P. Aue, M. Reinhold, and R.R. Ernst, Coherence transfer by radiofrequency pulses for heteronuclear detection of multiple quantum transitions, J. Magn. Resonance 40, 175 (1980).
A. Bax, S.P. Kempsell, and R. Freeman, Investigation of carbon-13-carbon-13 long range couplings in natural abundance samples, J. Magn. Resonance 41, 349 (1980).
A. Bax and R. Freeman, Investigation of carbon-13-carbon-13 couplings in natural abundance samples: the strong coupling case, J. Magn. Resonance 41, 507 (1980).
O.W. Sorensen, R. Freeman, T.A. Frenkiel, T.H. Mareci, and R. Schuck, Observation of carbon-13-cdrbon-13 coupling with enhanced sensitivity, J. Magn. Resonance 46, 180 (1982).
W. Ammann, R. Richarz, T. Wirthlin, and D. Wendisch, Proton and carbon-13 chemical shifts and coupling constants of lupane. Application of two—dimensional NMR techniques, Org. Magn. Resonance 20 (4), 260 (1982).
G.A. Gray, Multinuclear two—dimensional NMR: Assignments of natural abundance polypeptide 13C, lH and 15N chemical shifts and demonstration of isomer interconversion, Org. Magn. Resonance 21 (2), 111 (1983).
R. Richarz and W. Ammann, Practical Tips for Homonuclear 2D-NMR Experiments, Varian Application Note No. Z-81, July 1981.
2D NMR of Rotenone, Jeol Application Note No. NM 16 (1984).
R. Richarz, W. Ammann, and T. Wirthlin, XL-200/300 in DEPT (h): A New Experiment for the ADEPT Spectroscopist, Varían Application Note No. Z-15, Aug. 1982.
W. Ammann, R. Richarz and T. Wirthlin, COSMIC: A New Approach to Automatic Structure Elucidation. A Pascal Programme for the XL-200 Data System, Varían Application Note No. Z-12, April 1981.
A. Bax, R. Freeman, T.A. Frenkiel and M.H. Levitt, Assignment of carbon-13 NMR spectra via double quantum coherence, J. Magn. Resonance 43, 478 (1981).
G. Bodenhausen, R. Freeman, R. Niedermeyer, and D.L. Turner, Double Fourier transformation in high resolution NMR, J. Magn. Resonance 26, 133 (1977).
R. Freeman and G.A. Morris, Two—dimensional Fourier transformation in NMR, Bull. Magn. Resonance 1 (1), 5 (1979).
D.H. Williams, M.P. Williamson, D.W. Butcher, and S.J. Hammond, Detailed binding sites of the antibiotics vancomycin and ristocetin A: Determination of intermolecular distances in antibiotic/substrate complexes by use of the time—dependent NOE, J. Am. Chem. Soc. 105, 1332 (1983).
D. Wenhaus, R.N. Sheppard, and I.R.C. Bick, Structural and conformational study of repanduline using long-range nuclear Overhauser effect difference spectroscopy, J. Am. Chem. Soc. 105, 5996 (1983).
J.C. Steffens, J.L. Roark, D.G. Lynn, and J.R. Riopel, Host recognition in parasitic angiosperms: Use of correlation spectroscopy to identify long—range coupling in an haustorial inducer, J. Am. Chem. Soc. 105, 1669 (1983).
A.C. Pinto, M.L.A. Goncalves, R.B. Filho, A. Neszmelyi, and G. Lukacs, Natural abundance 13C-13C coupling constants observed via double quantum coherence: Structural elucidation of velloziolide, a diterpene with a novel skeleton, J. Chem. Soc., Chem. Commun., 293 (1982).
A. Bax, Two Dimensional Nuclear Magnetic Resonance in Liquids, Delft University Press, Delft, Holland (1982).
D.A. Aikens, S.C. Bunce, O.F. Onasch, H.M. Schwartz, and C. Hurwitz, Two dimensional NMR investigation of the protonation sequence in spermidine, J. Chem. Soc., Chem. Commun., 43 (1983).
E. Haslinger and H. Kalchhauser, 2D-NMR of natural products, Part III, Homo- and heteronuclear NMR-spectroscopy of a cyclic tetrapeptide related to chlamydocin, Tetrahedron Lett. 24 (25), 2553 (1983).
M.L. Martin, G.J. Martin, and J.J. Delpuech, Practical NMR Spectroscopy, Heyden and Sons Ltd., London (1980).
Two—dimensional NMR, Bruker Application Note, April 1982.
D.L. Foxall, New Water Suppression Experiments, Varian Application Note No. NMR-23, January 1984.
R. Richarz and T. Wirthlin, CCCP: Carbon—carbon Connectivity Plots on the XL-200, Varian Application Note No. 2 - 13, April 1983.
C. LeCocq and J.-Y. Lallemand, Precise carbon-13 NMR multiplicity determination, J. Chem. Soc., Chem. Commun., 150 (1981).
A.C. Pinto, S.K. Do Prado, R.B. Filho, W.E. Hull, A. Neszmelyi, and G. Lukacs, Natural abundance 13C-13C coupling constants observed via double quantum coherence. Structural elucidation by the one—and the two—dimensional NMR experiments of velloziolone, a new seco—diterpene, Tetrahedron Lett. 23 (50), 5267 (1982).
E.L. Ulrich, W.M. Westler, and J.L. Markley, Reassignments in the 1H-NMR spectrum of flavin adenine dinucteolide by two—dimensional homonuclear chemical shift correlation, Tetrahedron Lett. 24 (5), 473 (1983).
C.J. Turner, INEPT on the XL-200, Varían Application Note No. Z-ll, September 1980.
R. Richarz, W. Ammann, and T. Wirthlin, Relayed Coherence Transfer in 2D- NMR, Varían Application Note No. Z-17, September 1982.
A. Bax, Broadband homonuclear decoupling in heteronuclear shift correlation NMR spectroscopy, J. Magn. Resonance 53, 517 (1983).
M.L. Levitt, G. Bodenhausen, and R.R. Ernst, The illusions of spin decoupling, J. Magn. Resonance 53, 443 (1983).
G. Lukacs and A. Neszmelyi, Computer-assisted determination of carbon connectivity patterns based on natural abundance one—bond 13C-13C coupling constants: Terpenes, Tetrahedron Lett. 22 (50), 5053 (1981).
D.J. Cookson and B.E. Smith, Improved method for assignment of multiplicity in 13C-NMR spectroscopy with application to the analysis of mixtures, Org. Magn. Resonance 16 (2), 111 (1981).
M.R. Bendall and D.T. Pegg, 1H-13C two-dimensional chemical shift correlation spectroscopy using DEPT, J. Magn. Resonance 53, 144 (1983).
G. King and P.E. Wright, Application of two—dimensional relayed coherence transfer experiments to 1H-NMR studies of macromolecules, J. Magn. Resonance 54, 328 (1983).
J.N. Shoolery, Recent developments in 13C- and proton-NMR, J. Nat. Prod. 47 (2), 226 (1984).
H. Kessler and D. Ziessow, Zweidimensional NMR-spektroskopie, Nachr. Chem. Tech. Lab. 30 (6), 448 (1982).
D.L. Foxall, Broadband Decoupled Heteronuclear Correlation and Semiselective Heteronuclear 2D J Spectroscopy, Varian Application Note, 1984.
A. Bax, Two-dimensional heteronuclear relayed coherence transfer spectroscopy, J. Magn. Resonance 53, 149 (1983).
R. Benn and H. Günther, Modern pulse methods in high-resolution NMR spectroscopy, Angew. Chem., Int. Ed. Engl. 22, 350 (1983).
J.M. Bulsing, W.M. Brooks, J. Field, and D.M. Doddrell, Polarisation transfer via an intermediate multiple quantum state of maximum order, J. Magn. Resonance 56, 167 (1984).
M.J. Gidley and S.M. Bociek, Selective 2D-heteronuclear J-resolved NMR spectroscopy, J. Chem. Soc., Chem. Commun., 220 (1985).
J.A. Wilde and P.H. Bolton, Suppression of homonuclear couplings in heteronuclear two—dimensional spectroscopy, J. Magn. Resonance 59, 343 (1984).
T.T. Nakashima, B.K. John, and R.E.D. McClung, Selective 2D DEPT heteronuclear shift correlation spectroscopy, J. Magn. Resonance 59, 124 (1984) and references therein.
H. Kessler, C. Griesinger, J. Zarbock, and H.R. Looslie, Assignment of carbonyl carbons and sequence analysis in peptides by heteronuclear shift correlation via small coupling constants with broad-band decoupling in t 1(COLOC), J. Magn. Resonance 57, 331 (1984).
L. Muller, Mapping of spin—spin coupling via zero—quantum coherence, J. Magn. Resonance 59, 326 (1984).
P.J. Hore, Two—dimensional chemical shift correlation using water suppression pulses, J. Magn. Resonance 56, 535 (1984) and references therein.
C. Yu and G.C. Levy, J. Am. Chem. Soc. 106,6533 (1984) and references therein.
G. Wagner, Two dimensional relayed coherence transfer-NOE spectroscopy, J. Magn. Resonance 57, 497 (1984)
C.A.G. Haasnoot, F.J.M. van de Ven, and C.W. Hilbers, COCONOSY, com-bination of 2D correlated and 2D nuclear Overhauser enhancement spectroscopy in a single experiment, J. Magn. Resonance 56, 343 (1984).
M.A. Delsuc, E. Guittet, N. Trotin, and J.Y. Lallemand, Two dimensional correlation spectroscopy with heteronuclear relay, J. Magn. Resonance 56, 163 (1984).
M. Ikura and K. Hikichi, Two dimensional double quantum coherence echo correlated spectroscopy (DECSY), J. Am. Chem. Soc. 106, 4275 (1984) and references therein.
S. Macura, N.G. Kumar, and L.R. Brown, Homonuclear relayed double quantum 2D NMR spectroscopy, J. Magn. Resonance 60, 99 (1984).
D. Neuhaus, G. Wider, G. Wagner, and K. Wuthrich, X-Relayed lH-lH correlated spectroscopy, J. Magn. Resonance 57, 164 (1984) and references therein.
E. Breitmaier, Die Kohlenstoff-13-NMR Spektroskopie, Pharmazie in unserer Zeit 13 (4), 102 (1984).
H. Günther and P. Schmitt, Zweidimensionale Messtechniken der Hochauflosenden Kernresonanzspektroskopie (Teil I): J, δ Spektren, Kontakte (2), 3 (1985).
H. Kessler, A. Muller, and H. Oschkinat, Differences and sums of traces within COSY spectra (DISCO) for the extraction of coupling constants: decoupling after the measurement, Magn. Resonance in Chemistry, 23 (10), 844 (1985).
H. Kessler, W. Bermel, and C. Griesinger, Recognition of NMR proton spin systems of cyclosporin A via heteronuclear proton—carbon long range couplings, J. Am. Chem. Soc., 107, 1083 (1985).
H. Kessler, W. Bermel, and C. Griesinger, Determination of carbon—carbon connectivities, assignments of quaternary carbon atoms, and extraction of carbon—carbon coupling constants by carbon relayed hydrogen—carbon spectroscopy, J. Magn. Resonance, 62, 573 (1985).
M.J. Gidley and S.M. Bociek, Long-range 13C-1H coupling in carbohydrates by selective 2D heteronuclear J-resolved NMR spectroscopy, J. Chem. Soc., Chem. Commun., 220(1985).
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Atta-ur-Rahman (1986). Special Pulse Sequences and Two-Dimensional NMR Spectroscopy. In: Nuclear Magnetic Resonance. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4894-1_5
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