Abstract
In EBV immortalized lymphoblastoid cell lines (LCLs) a small number of “latent” proteins are expressed: EBV nuclear antigens, EBNAs 1–6 and a latent membrane protein (LMP)1,2. We have investigated these “latent” proteins in a nude mouse propagated NPC tumour, C153,4, in EBV associated transplant lymphomas5 and in a newly established Burkitt’s lymphoma (BL) cell line (D.K, unpublished) by western-immunoblotting. The transplant tumours appear to have a pattern of latent protein expression very similar to that in LCLs, that is, EBNAs 1–6 and LMP, are found. However, in both the BL and NPC, EBNA expression is restricted to EBNA1. (In the NPC, but not in the BL, LMP is also expressed.)
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© 1989 The Humana Press Inc.
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Allday, M.J., Kundu, D., Griffin, B.E. (1989). EBNA Expression and CpG Methylation of Viral DNA in EBV Associated Tumours. In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_7
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DOI: https://doi.org/10.1007/978-1-4612-4508-7_7
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