Abstract
The Epstein-Barr virus (EBV) is implicated in a variety of diseases. We have detected EBV DNA in lymphoid tissue specimens from patients with Burkitt’s lymphoma (BL) and lymphoproliferations which have developed in patients with immune disorders including Wiskott-Aldrich syndrome (WA), Chediak-Higashi syndrome (CH), X-linked lymphoproliferative syndrome (XLP), and severe-combined immunodeficiency (SCID). We have also detected EBV DNA in epithelial tissues including nasopharyngeal carcinoma of all three histologic subtypes (NPC), carcinomas of the base of the tongue, and carcinoma of the parotid gland. In order to understand the pathogenetic diversity of infection with EBV, we sought to determine the state of viral infection and to compare viral expression in infected tissues from a variety of EBV infections.
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References
Arrand, J.,. L. Rymo, J. Virol. 41, 376 (1982).
P. Busson, G. Ganem et al., Int. J. Cancer 42, 599 (1988).
Dambaugh, T., K. Hennessy et al., Proc. Natl. Acad. Sci. USA 81, 7632 (1984).
Given, D., D. Yee et al., J. Virol. 30, 852 (1979).
Greenspan, J.S., D. Greenspan et al., New Engl. J. Med. 313, 1564 (1985).
Hanto, D.W., K.J. Gajl-Peczalska, K.J. et al., Ann. Surg. 198, 356 (1983).
Henle, W., G. Henle, Int. J. Cancer 17, 1 (1976).
Hudson, G.S., P.J. Farrell et al., J. Virol. 53, 528 (1985).
Lerner, M.R., N.C. Andrews et al., Proc. Natl. Acad. Sci. USA 78, 805 (1981).
Niederman, J.C., G. Miller et al.., New Enql. J. Med. 294, 1355 (1976).
Raab-Traub, N., R. Hood et al., J. Virol. 48, 580 (1983).
Raab-Traub, N., K. Flynn, Cell 47, 883 (1986).
Sample, J., M. Hummel et al., Proc. Natl. Acad. Sci. USA 83, 6096 (1986).
Wang, D., D. Liebowitz, D. et al., Cell 43, 831 (1985).
Wang, D., D. Liebowitz, D. et al., J. Virol. 62, 2337 (1988).
Wolf, H., M. Haus et al., J. Virol. 51, 795 (1984).
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© 1989 The Humana Press Inc.
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Raab-Traub, N., Gilligan, K., Sato, H., Flynn, K., Edmiston, S.N., Chen, JJ. (1989). EBV DNA Structure and Expression in EBV-Induced Proliferations. In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_12
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DOI: https://doi.org/10.1007/978-1-4612-4508-7_12
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