Abstract
Listeria monocytogenes is a gram positive, rapidly growing, facultative, intracellular bacterial pathogen which occurs free-living in nature as well as in association with a variety of warm-blooded animals (Gellin et al., 1989). The oral route is the natural route of transmission in humans as a number of well-documented cases have been traced to ingestion of contaminated foods. In fact, the presence of L. monocytogenes in food has become a major concern of the food industry.
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References
Bernardini, M.L., et al., 1989, icsA, a plasmid locus of Shigella flexneri, governs bacterial intra- and intercellular spread through interaction with F-actin, Proc. Natl. Acad. Sci. USA, 86:3867–3871.
Bielecki, J., et al., 1990, Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells, Nature 345:175–176.
Camilli, A., Portnoy, D.A., and Youngman, P., 1990, Insertional mutagenesis of Listeria monocytogenes with a novel Tn917 derivative that allows direct cloning of DNA flanking transposon insertions, J. Bacteriol. 172:3738–3744.
Cossart, P., et al., 1989, Listeriolysin O is essential for virulence of Listeria monocytogenes: direct evidence obtained by gene complementation, Infect. Immun. 57:3629–3636.
Dabiri, G.A., et al, 1990, Listeria monocytogenes moves rapidly through the host cell cytoplasm by inducing directional actin assembly, Proc. Natl. Acad. Sci USA. 87:6068–6072.
Gaillard, J.L., Berche, P., and Sansonetti, P., 1986, Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes, Infect Immun. 52:50–55.
Gaillard, J.L., et al., 1987, In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2, Infect Immun. 55:2822–2829.
Gellin, B. G., and Broome, C.V., 1989, Listeriosis, J. Am. Med. Assoc. 261:1313–1320.
Geoffroy, G, et al., 1987, Purification, characterization, and toxicity of the sulfhydryl-activated hemolysin listeriolysin O from Listeria monocytogenes, Infect Immun. 55:1641–1646.
Hahn, H., and Kaufman, S.H.E., 1981, The role of cell-mediated immunity in bacterial infections, Rev. Infect Dis. 3:1221–1250.
Havell, E.A., 1986, Synthesis and secretion of interferon by murine fibroblasts in response to intracellular Listeria monocytogenes, Infect Immun. 54:787–792.
Jacobs, J.L., and Murray, H.W., 1986, Why is Listeria monocytogenes not a pathogen in the acquired immunodeficiency syndrome? Arch. Intern. Med. 146:1299–1300.
Kathariou, S., et aL., 1987, Tn916-induced mutations in the hemolysin determinant affecting virulence of Listeria monocytogenes, J. Bacteriol. 169:1291–1297.
Kehoe, M.A., et al., 1987, Nucleotide sequence of the streptolysin O (SLO) gene: structural homologies between SLO and other membrane damaging, thiol-activated toxins, Infect Immun. 55:3228–3232.
Kuhn, M, Kathariou, S., and Goebel, W., 1988, Hemolysin supports survival but not entry of the intracellular bacterium Listeria monocytogenes, Infect Immun. 56:79–82.
Ley, V., et aL., 1990, The exit of Trypanosoma cruzi from the phagosome is inhibited by raising the pH of acidic compartments, J. Exp. Med. 171:401–413.
Mackaness, G.B., 1962, Cellular resistance to infection, J. Exp. Med. 116:381–406.
Maxfield, F.R., 1982, Weak bases and ionophores rapidly and reversibly raise the pH of endocytic vesicles in cultured mouse fibroblasts, J. Cell BioL. 95:676–681.
Mounier, J., et al., 1990, Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocyte-like cell line Caco-2, Infect. Immun. 58:1048–1058.
Newborg, M.F., and North, R.J., 1980, On the mechanism of T cell independent anti-listerial resistance in nude mice, J. Immunol 124:571–576.
North, R.J., 1970, The relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection. J Exp. Med. 132:521–534.
Oaks, E.V., Wingfield, M.E., and Formal, S.B., 1985, Plaque formation by virulent Shigella flexneri, Infect. Immun. 48:124–129.
Pal, T., et aL., 1989, Intracellular spread of Shigella flexneri associated with the kcpA locus and a 140-kilodalton protein, Infect. Immun. 57:477–486.
Portnoy, D.A., Jacks, P.S., and Hinrichs, D.J., 1988, Role of hemolysin for the intracellular growth of Listeria monocytogenes, J. Exp. Med. 167:1459–1471.
Racz, P., Tenner, K., and Mero, E., 1972, Experimental Listeria enteritis. I. An electron microscopic study of the epithelial phase in experimental Listeria infection, Lab. Invest. 26:694–700.
Rosen, H., Gordon, S., and North, R.J., 1989, Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells. Absence of monocytes at infective foci allows Listeria to multiply in non-phagocytic cells, J Exp. Med. 170:27–37.
Sansonetti, PJ., et al., 1986, Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis, Infect Immun. 51:461–469.
Smyth, C.J., and Duncan, J. L., 1978, Thiol-activated (oxygen-labile) cytolysins. p. 129–183. In J. Jeljaszewicz and T. Wadstrom (ed.) Bacterial toxins and cell membranes. Academic Press, Inc. (London), Ltd., London.
Sun, A.N., Camilli, A., and Portnoy, D.A., 1990, Isolation of Listeria monocytogenes small-plaque mutants defective for intracellular growth and cell-to-cell spread, Infect Immun. 58:3770–3778.
Tilney, L. G., and Portnoy, D.A., 1989, Actin filaments and the growth movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes, J. Cell Biol. 109:1597–1608.
Winkler, H.H., and Turco, J., 1988, Rickettsia prowazekii and the host cell: entry with, and control of the parasite, Curr. Top. Microbiol. Immunol. 138:81–107.
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© 1992 Springer-Verlag New York, Inc.
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Portnoy, D.A., Sun, A.N., Bielecki, J. (1992). Escape from the Phagosome and Cell-to-Cell Spread of Listeria monocytogenes . In: Hook, M., Switalski, L. (eds) Microbial Adhesion and Invasion. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2924-7_8
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DOI: https://doi.org/10.1007/978-1-4612-2924-7_8
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