Abstract
Understanding the pathogenesis of virus infections requires study of both viral and cell factors that contribute to the outcome of an infection. Our work has addressed two aspects of poliovirus pathogenesis: the molecular and functional basis of host range and tissue tropism. It has become apparent that understanding virus-receptor interactions is necessary to provide explanations of both characteristics. Therefore, studies on the cellular receptor for poliovirus (PVR) have become an integral part of our research aims. We shall, in this communication, first consider briefly the structure of the PVR and some of its properties, and then we will turn to studies on the role of the PVR in poliovirus host range and tissue tropism.
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© 1992 Springer-Verlag New York, Inc.
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Racaniello, V.R., Moss, E.G., Kaplan, G., Ren, R. (1992). Interaction of Poliovirus with its Immunoglobulin-like Cell Receptor. In: Hook, M., Switalski, L. (eds) Microbial Adhesion and Invasion. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2924-7_5
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DOI: https://doi.org/10.1007/978-1-4612-2924-7_5
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