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[Ca2+]i and Contraction of Arterial Smooth Muscle

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

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Abstract

Most contractile stimuli induce arterial smooth muscle contraction by increasing myoplasmic [Ca2+] ([Ca2+]i). Ca2+ binds to calmodulin and activates myosin light chain kinase.1 The activated myosin light chain kinase phosphorylates the 20kDa light chain of myosin at serine 19 and activates the myosin’s ATPase.2 The phosphorylated myosin binds to actin filaments, cycles, and produces shortening and/or force.3 This is the most widely accepted mechanism for the regulation of smooth muscle contraction. In this chapter, I will discuss in detail the mechanisms regulating [Ca2+]i and the dependence of contractile force of myosin light chain phosphorylation. I will also briefly discuss the mechanisms altering the dependence of myosin phosphorylation on [Ca2+]i (ie, the [Ca2+]i sensitivity of phosphorylation).

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  1. Christopher M. Rembold
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Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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Rembold, C.M. (1994). [Ca2+]i and Contraction of Arterial Smooth Muscle. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_8

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_8

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