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Calcium Channels in Cells of the Anterior Pituitary

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

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Abstract

The mechanisms by which hypothalamic releasing and inhibiting peptides and amines control the release of anterior pituitary hormones have been the object of intense investigation for many years. They involve membrane-bound enzymes such as adenylate cyclase, and phospholipases C and A2, which liberate second messengers such as cAMP, inositol phosphates, free fatty acids, and diacylglycerides, as well as membrane-resident regulatory proteins (G proteins), which couple these enzymes to the hypothalamic hormone receptors. In addition, intracellular kinases and phosphatases that control the degree of phosphorylation and dephosphorylation of important intracellular proteins participate in the control of pituitary hormone secretion. The actions of these intracellular substances are intimately related to those of the central regulator of secretion, the calcium ion.

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Authors
  1. David M. Lawson
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Editor information

Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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© 1994 Springer-Verlag New York, Inc.

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Lawson, D.M. (1994). Calcium Channels in Cells of the Anterior Pituitary. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_5

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7599-2

  • Online ISBN: 978-1-4612-2596-6

  • eBook Packages: Springer Book Archive

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