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Transport Systems for Arsenic, Antimony, and Cadmium Ions Encoded by Bacterial Plasmids

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Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

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Abstract

Heavy metal ions are ubiquitous and have beneficial and deleterious actions at the same time.1,2 For this reason cells frequently have inwardly directed transport systems for their uptake and utilization and outwardly directed systems for extrusion and protection. Salts of arsenic were the first chemotherapeutic agents used in treatment of infectious diseases;3 indeed, Paul Ehrlich was awarded the 1908 Nobel Prize in Medicine for the development of the antimicrobial arsenical salvarsan, the “magic bullet” that cured syphilis. In his Nobel Award address Ehrlich pointed out that to be effective and arsenical had be taken up into the cells by an arsenical receptor. He also noted that, soon after the start of drug therapy, arsenical resistant organisms appeared, and he postulated that these organisms were resistant because they could no longer take up the toxic arsenical. Our studies in the 1990s expand on Ehrlich’s ideas.

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Authors
  1. Anita R. Lynn
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  2. Barry P. Rosen
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Editor information

Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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© 1994 Springer-Verlag New York, Inc.

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Lynn, A.R., Rosen, B.P. (1994). Transport Systems for Arsenic, Antimony, and Cadmium Ions Encoded by Bacterial Plasmids. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_25

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_25

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7599-2

  • Online ISBN: 978-1-4612-2596-6

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