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Ion Transport in Vascular Smooth Muscle and the Pathogenesis of Hypertension

  • Chapter
Ion Channels and Ion Pumps

Part of the book series: Endocrinology and Metabolism ((EAM,volume 6))

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Abstract

Over the last 10–15 years a number of reports have documented that hypertension is associated with changes in a variety of ion transport systems, although it has been difficult to define the significance of these changes. One of the reasons for this difficulty is that in human essential hypertension evidence for changes in the ion transport over cell membranes stems from observations in blood cells. If these abnormalities are to play a pathogenetic role they should, however, be present in vascular smooth muscle cells (VSMC), neurons, or the kidney from patients with essential hypertension as well. Confirmation of this by direct measurements has been difficult for technical and ethical reasons. Information concerning ion transport abnormalities in VSMC in hypertension has, however, been obtained from experiments with different types of experimental hypertension, although the extent to which this information is relevant in essential hypertension is open for discussion. With respect to the animals (mainly rats) with genetic forms of hypertension the choice of normotensive controls is a problem (see below), while in the case of secondary forms of experimental hypertension a major problem is the lack of genetic predisposition, which is an important aspect of essential hypertension. Another difficulty is the poor understanding of the physiologic importance of the various ion transport systems in VSMC. Hence the pathogenetic significance of any abnormality is difficult to predict.

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Authors
  1. Christian Aaljæ
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  2. Keld Kjeldsen
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Editors and Affiliations

  1. 48323, 2104 Rhine Road, West Bloomfield, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  2. Department of Physiology, Wayne State University, 48202, Detroit, MI, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus) (Professor Emeritus)

  3. Section of Endocrinology,Department of Internal Medicine,School of Medicine, Wayne State University, 48202, Detroit, MI, USA

    Mary F. Walsh Ph.D. (Assistant Professor) (Assistant Professor)

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Aaljæ, C., Kjeldsen, K. (1994). Ion Transport in Vascular Smooth Muscle and the Pathogenesis of Hypertension. In: Foà, P.P., Walsh, M.F. (eds) Ion Channels and Ion Pumps. Endocrinology and Metabolism, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2596-6_18

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  • DOI: https://doi.org/10.1007/978-1-4612-2596-6_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7599-2

  • Online ISBN: 978-1-4612-2596-6

  • eBook Packages: Springer Book Archive

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